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Synthesis and biological activity of oxazolopyrimidines

Laurens De Coen (UGent) , Bart Roman (UGent) , Marine Movsisyan (UGent) , Thomas Heugebaert (UGent) and Christian Stevens (UGent)
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Abstract
In this work, the synthesis of oxazolo[4,5-d]pyrimidines and oxazolo[5,4-d]pyrimidines is reviewed. The review is focused on the construction of the scaffold rather than on its further modification. Nevertheless, selected examples illustrate some of the most common modifications of these scaffolds. The synthetic part is complemented by an overview of their biological activity. This review covers literature and patents from 1967 until the present.
Keywords
Cyclization, Annulation, Oxazolopyrimidines, Nucleobase isosteres, Fused-ring systems, ANTITUMOR AGENTS, INHIBITORS, ANTAGONISTS, 2_4-DIAMINO-5-HYDROXY-6-METHYLPYRIMIDINE, OXAZOLO<4_ 5-B>PYRIDINES, CARBOXYLATES, DERIVATIVES, AMIDINES

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Chicago
De Coen, Laurens, Bart Roman, Marine Movsisyan, Thomas Heugebaert, and Christian Stevens. 2018. “Synthesis and Biological Activity of Oxazolopyrimidines.” European Journal of Organic Chemistry (19): 2148–2166.
APA
De Coen, L., Roman, B., Movsisyan, M., Heugebaert, T., & Stevens, C. (2018). Synthesis and biological activity of oxazolopyrimidines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (19), 2148–2166.
Vancouver
1.
De Coen L, Roman B, Movsisyan M, Heugebaert T, Stevens C. Synthesis and biological activity of oxazolopyrimidines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2018;(19):2148–66.
MLA
De Coen, Laurens et al. “Synthesis and Biological Activity of Oxazolopyrimidines.” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 19 (2018): 2148–2166. Print.
@article{8562391,
  abstract     = {In this work, the synthesis of oxazolo[4,5-d]pyrimidines and oxazolo[5,4-d]pyrimidines is reviewed. The review is focused on the construction of the scaffold rather than on its further modification. Nevertheless, selected examples illustrate some of the most common modifications of these scaffolds. The synthetic part is complemented by an overview of their biological activity. This review covers literature and patents from 1967 until the present.},
  author       = {De Coen, Laurens and Roman, Bart and Movsisyan, Marine and Heugebaert, Thomas and Stevens, Christian},
  issn         = {1434-193X},
  journal      = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
  language     = {eng},
  number       = {19},
  pages        = {2148--2166},
  title        = {Synthesis and biological activity of oxazolopyrimidines},
  url          = {http://dx.doi.org/10.1002/ejoc.201800133},
  year         = {2018},
}

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