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Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer: Evaluation in a porcine model

Tim Boussy, Tim Vandecasteele UGent, Lisse Vera UGent, Stijn Schauvliege UGent, Matthew Philpott, Eli Clement, Gunther van Loon UGent, Udi Willenz, Juan F. Granada, Gregg W. Stone, et al. (2018) PACE.
abstract
Background: Pulmonary vein isolation (PVI) is a well-established method for the treatment of symptomatic paroxysmal atrial fibrillation, but is only partly successful with a high rate of electrical reconnection.We introduce a novel technique in which PVI is accomplished by noninvasive heating of a dedicated thermoresponse implant inserted into the pulmonary veins (PV), demonstrated in a porcinemodel. Methods: A self-expanding nitinol-based implant was positioned in the common inferior PV of 11 pigs, using a fluoroscopy-guided transatrial appendage approach. Ablation was performed through contactless energy transfer from a primary extracorporal coil to a secondary heat ring (HR) embedded in the proximal part of the implant. Electrophysiological conduction was assessed prior to and postablation, and at 3 months. Histological sampleswere obtained acutely (n = 4) and after 3 months (n = 7). Results: In total, 13 PV implants were successfully positioned in the inferior PVs of 11 animals. Ablation was performed without injury of adjacent structures. PVI and bidirectional block was electrophysiologically confirmed in all cases immediately at the time of implantation and 3 months later in seven chronic animals in whom testingwas repeated. Marked evidence of ablation around the proximalHRwas evident at 3 months postprocedure,with scar tissue formation and only mild neointimal proliferation. Conclusions: Successful PVI can be obtained by external electromagnetic heat transfer to a novel pulmonary vein implant.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle
publication status
published
subject
keyword
ablation, atrial fibrillation, myocardial sleeve, stent
journal title
PACE
publisher
Wiley
ISSN
0147-8389
DOI
10.1111/pace.13345
UGent publication?
yes
classification
U
copyright statement
I don't know the status of the copyright for this publication
id
8562271
handle
http://hdl.handle.net/1854/LU-8562271
date created
2018-05-18 13:25:49
date last changed
2018-05-18 13:27:37
@article{8562271,
  abstract     = {Background: Pulmonary vein isolation (PVI) is a well-established method for the treatment of
symptomatic paroxysmal atrial fibrillation, but is only partly successful with a high rate of electrical
reconnection.We introduce a novel technique in which PVI is accomplished by noninvasive
heating of a dedicated thermoresponse implant inserted into the pulmonary veins (PV), demonstrated
in a porcinemodel.
Methods: A self-expanding nitinol-based implant was positioned in the common inferior PV of
11 pigs, using a fluoroscopy-guided transatrial appendage approach. Ablation was performed
through contactless energy transfer from a primary extracorporal coil to a secondary heat ring
(HR) embedded in the proximal part of the implant. Electrophysiological conduction was assessed
prior to and postablation, and at 3 months. Histological sampleswere obtained acutely (n = 4) and
after 3 months (n = 7).
Results: In total, 13 PV implants were successfully positioned in the inferior PVs of 11 animals.
Ablation was performed without injury of adjacent structures. PVI and bidirectional block was
electrophysiologically confirmed in all cases immediately at the time of implantation and 3 months
later in seven chronic animals in whom testingwas repeated. Marked evidence of ablation around
the proximalHRwas evident at 3 months postprocedure,with scar tissue formation and only mild
neointimal proliferation.
Conclusions: Successful PVI can be obtained by external electromagnetic heat transfer to a novel
pulmonary vein implant.},
  author       = {Boussy, Tim and Vandecasteele, Tim and Vera, Lisse and Schauvliege, Stijn and Philpott, Matthew and Clement, Eli and van Loon, Gunther and Willenz, Udi and Granada, Juan F. and Stone, Gregg W. and Reddy, Vivek Y. and Van Langenhove, Glenn},
  issn         = {0147-8389},
  journal      = {PACE},
  keyword      = {ablation,atrial fibrillation,myocardial sleeve,stent},
  publisher    = {Wiley},
  title        = {Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer: Evaluation in a porcine model},
  url          = {http://dx.doi.org/10.1111/pace.13345},
  year         = {2018},
}

Chicago
Boussy, Tim, Tim Vandecasteele, Lisse Vera, Stijn Schauvliege, Matthew Philpott, Eli Clement, Gunther van Loon, et al. 2018. “Isolation of Pulmonary Veins Using a Thermoreactive Implantable Device with External Energy Transfer: Evaluation in a Porcine Model.” Pace.
APA
Boussy, T., Vandecasteele, T., Vera, L., Schauvliege, S., Philpott, M., Clement, E., van Loon, G., et al. (2018). Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer: Evaluation in a porcine model. PACE.
Vancouver
1.
Boussy T, Vandecasteele T, Vera L, Schauvliege S, Philpott M, Clement E, et al. Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer: Evaluation in a porcine model. PACE. Wiley; 2018;
MLA
Boussy, Tim, Tim Vandecasteele, Lisse Vera, et al. “Isolation of Pulmonary Veins Using a Thermoreactive Implantable Device with External Energy Transfer: Evaluation in a Porcine Model.” PACE (2018): n. pag. Print.