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Nanos genes and their role in development and beyond

Evi De Keuckelaere UGent, Paco Hulpiau UGent, Yvan Saeys UGent, Geert Berx UGent and Frans Van Roy UGent (2018) CELLULAR AND MOLECULAR LIFE SCIENCES. 75(11). p.1929-1946
abstract
The hallmark of Nanos proteins is their typical (CCHC)(2) zinc finger motif (zf-nanos). Animals have one to four nanos genes. For example, the fruit fly and demosponge have only one nanos gene, zebrafish and humans have three, and Fugu rubripes has four. Nanos genes are mainly known for their evolutionarily preserved role in germ cell survival and pluripotency. Nanos proteins have been reported to bind the C-terminal RNA-binding domain of Pumilio to form a post-transcriptional repressor complex. Several observations point to a link between the miRNA-mediated repression complex and the Nanos/Pumilio complex. Repression of the E2F3 oncogene product is, indeed, mediated by cooperation between the Nanos/Pumilio complex and miRNAs. Another important interaction partner of Nanos is the CCR4-NOT deadenylase complex. Besides the tissue-specific contribution of Nanos proteins to normal development, their ectopic expression has been observed in several cancer cell lines and various human cancers. An inverse correlation between the expression levels of human Nanos1 and Nanos3 and E-cadherin was observed in several cancer cell lines. Loss of E-cadherin, an important cell-cell adhesion protein, contributes to tumor invasion and metastasis. Overexpression of Nanos3 induces epithelial-mesenchymal transition in lung cancer cell lines partly by repressing E-cadherin. Other than some most interesting data from Nanos knockout mice, little is known about mammalian Nanos proteins, and further research is needed. In this review, we summarize the main roles of Nanos proteins and discuss the emerging concept of Nanos proteins as oncofetal antigens.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
GERM-CELL DEVELOPMENT, HUNCHBACK MESSENGER-RNA, POSTERIOR MORPHOGEN, NANOS, BINDING-PROTEIN, CCR4-NOT COMPLEX, BRAIN-TUMOR, TRANSLATIONAL, REPRESSION, CAENORHABDITIS-ELEGANS, DROSOPHILA EMBRYOS, STEM-CELLS, Nanos, Pumilio, Germ cell specification, Cancer, Phylogeny, RNA-binding, protein, RNA regulation, Multiprotein complexes, Cancer testis antigen, pRb deficiency
journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
Cell. Mol. Life Sci.
volume
75
issue
11
pages
18 pages
publisher
Springer Basel Ag
place of publication
Basel
Web of Science type
Review
Web of Science id
000430975400002
ISSN
1420-682X
1420-9071
DOI
10.1007/s00018-018-2766-3
language
English
UGent publication?
yes
classification
U
copyright statement
I don't know the status of the copyright for this publication
id
8562260
handle
http://hdl.handle.net/1854/LU-8562260
date created
2018-05-18 13:11:59
date last changed
2018-05-18 13:11:59
@article{8562260,
  abstract     = {The hallmark of Nanos proteins is their typical (CCHC)(2) zinc finger motif (zf-nanos). Animals have one to four nanos genes. For example, the fruit fly and demosponge have only one nanos gene, zebrafish and humans have three, and Fugu rubripes has four. Nanos genes are mainly known for their evolutionarily preserved role in germ cell survival and pluripotency. Nanos proteins have been reported to bind the C-terminal RNA-binding domain of Pumilio to form a post-transcriptional repressor complex. Several observations point to a link between the miRNA-mediated repression complex and the Nanos/Pumilio complex. Repression of the E2F3 oncogene product is, indeed, mediated by cooperation between the Nanos/Pumilio complex and miRNAs. Another important interaction partner of Nanos is the CCR4-NOT deadenylase complex. Besides the tissue-specific contribution of Nanos proteins to normal development, their ectopic expression has been observed in several cancer cell lines and various human cancers. An inverse correlation between the expression levels of human Nanos1 and Nanos3 and E-cadherin was observed in several cancer cell lines. Loss of E-cadherin, an important cell-cell adhesion protein, contributes to tumor invasion and metastasis. Overexpression of Nanos3 induces epithelial-mesenchymal transition in lung cancer cell lines partly by repressing E-cadherin. Other than some most interesting data from Nanos knockout mice, little is known about mammalian Nanos proteins, and further research is needed. In this review, we summarize the main roles of Nanos proteins and discuss the emerging concept of Nanos proteins as oncofetal antigens.},
  author       = {De Keuckelaere, Evi and Hulpiau, Paco and Saeys, Yvan and Berx, Geert and Van Roy, Frans},
  issn         = {1420-682X},
  journal      = {CELLULAR AND MOLECULAR LIFE SCIENCES},
  keyword      = {GERM-CELL DEVELOPMENT,HUNCHBACK MESSENGER-RNA,POSTERIOR MORPHOGEN,NANOS,BINDING-PROTEIN,CCR4-NOT COMPLEX,BRAIN-TUMOR,TRANSLATIONAL,REPRESSION,CAENORHABDITIS-ELEGANS,DROSOPHILA EMBRYOS,STEM-CELLS,Nanos,Pumilio,Germ cell specification,Cancer,Phylogeny,RNA-binding,protein,RNA regulation,Multiprotein complexes,Cancer testis antigen,pRb deficiency},
  language     = {eng},
  number       = {11},
  pages        = {1929--1946},
  publisher    = {Springer Basel Ag},
  title        = {Nanos genes and their role in development and beyond},
  url          = {http://dx.doi.org/10.1007/s00018-018-2766-3},
  volume       = {75},
  year         = {2018},
}

Chicago
De Keuckelaere, Evi, Paco Hulpiau, Yvan Saeys, Geert Berx, and Frans Van Roy. 2018. “Nanos Genes and Their Role in Development and Beyond.” Cellular and Molecular Life Sciences 75 (11): 1929–1946.
APA
De Keuckelaere, E., Hulpiau, P., Saeys, Y., Berx, G., & Van Roy, F. (2018). Nanos genes and their role in development and beyond. CELLULAR AND MOLECULAR LIFE SCIENCES, 75(11), 1929–1946.
Vancouver
1.
De Keuckelaere E, Hulpiau P, Saeys Y, Berx G, Van Roy F. Nanos genes and their role in development and beyond. CELLULAR AND MOLECULAR LIFE SCIENCES. Basel: Springer Basel Ag; 2018;75(11):1929–46.
MLA
De Keuckelaere, Evi, Paco Hulpiau, Yvan Saeys, et al. “Nanos Genes and Their Role in Development and Beyond.” CELLULAR AND MOLECULAR LIFE SCIENCES 75.11 (2018): 1929–1946. Print.