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Fibro-osseous pseudotumor of digits : expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement

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Abstract
Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). Of the five patients included, three were female and two were male. The age ranged from 33 to 72 years (mean 48 years). Lesions arose in the palm (n = 2), thenar (n = 1), middle finger (n = 1) and great toe (n = 1). All patients underwent resection. Four cases (80%) harbored USP6 rearrangements showing that fibro-osseous pseudotumors of digits belongs to the spectrum of clonal transient neoplasms including aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesion of small bones.
Keywords
USP6 rearrangement, Fibro-osseous pseudotumor of digits, Soft tissue tumors, ANEURYSMAL BONE-CYST, PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION, NODULAR FASCIITIS, SOFT-TISSUE, MYOSITIS-OSSIFICANS, TRANSLOCATION, EXOSTOSIS, LESION, FUSION, TUMOR

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Chicago
Flucke, Uta, Sarah J Shepard, Elise M Bekers, Roberto Tirabosco, Paul J van Diest, David Creytens, and Joost M van Gorp. 2018. “Fibro-osseous Pseudotumor of Digits : Expanding the Spectrum of Clonal Transient Neoplasms Harboring USP6 Rearrangement.” Annals of Diagnostic Pathology 35: 53–55.
APA
Flucke, U., Shepard, S. J., Bekers, E. M., Tirabosco, R., van Diest, P. J., Creytens, D., & van Gorp, J. M. (2018). Fibro-osseous pseudotumor of digits : expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement. ANNALS OF DIAGNOSTIC PATHOLOGY, 35, 53–55.
Vancouver
1.
Flucke U, Shepard SJ, Bekers EM, Tirabosco R, van Diest PJ, Creytens D, et al. Fibro-osseous pseudotumor of digits : expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement. ANNALS OF DIAGNOSTIC PATHOLOGY. 2018;35:53–5.
MLA
Flucke, Uta, Sarah J Shepard, Elise M Bekers, et al. “Fibro-osseous Pseudotumor of Digits : Expanding the Spectrum of Clonal Transient Neoplasms Harboring USP6 Rearrangement.” ANNALS OF DIAGNOSTIC PATHOLOGY 35 (2018): 53–55. Print.
@article{8561777,
  abstract     = {Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. 
USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. 
We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). 
Of the five patients included, three were female and two were male. The age ranged from 33 to 72 years (mean 48 years). Lesions arose in the palm (n = 2), thenar (n = 1), middle finger (n = 1) and great toe (n = 1). All patients underwent resection. 
Four cases (80\%) harbored USP6 rearrangements showing that fibro-osseous pseudotumors of digits belongs to the spectrum of clonal transient neoplasms including aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesion of small bones.},
  author       = {Flucke, Uta and Shepard, Sarah J and Bekers, Elise M and Tirabosco, Roberto and van Diest, Paul J and Creytens, David and van Gorp, Joost M},
  issn         = {1092-9134},
  journal      = {ANNALS OF DIAGNOSTIC PATHOLOGY},
  keyword      = {USP6 rearrangement,Fibro-osseous pseudotumor of digits,Soft tissue tumors,ANEURYSMAL BONE-CYST,PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION,NODULAR FASCIITIS,SOFT-TISSUE,MYOSITIS-OSSIFICANS,TRANSLOCATION,EXOSTOSIS,LESION,FUSION,TUMOR},
  language     = {eng},
  pages        = {53--55},
  title        = {Fibro-osseous pseudotumor of digits : expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement},
  url          = {http://dx.doi.org/10.1016/j.anndiagpath.2018.05.003},
  volume       = {35},
  year         = {2018},
}

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