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Biomarkers for monitoring intestinal health in poultry : present status and future perspectives

Richard Ducatelle (UGent) , Evy Goossens (UGent) , Fien De Meyer (UGent) , Venessa Eeckhaut (UGent) , Gunther Antonissen (UGent) , Freddy Haesebrouck (UGent) and Filip Van Immerseel (UGent)
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Abstract
Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the intestinal microbiome (dysbiosis), leakage of the mucosal barrier and/or inflammation. Since the ban on growth promoting antimicrobials in animal feed, these dysbiosis-related problems have become a major issue, especially in intensive animal farming. The economical and animal welfare consequences are considerable. Consequently, there is a need for continuous monitoring of the intestinal health status, particularly in intensively reared animals, where the intestinal function is often pushed to the limit. In the current review, the recent advances in the field of intestinal health biomarkers, both in human and veterinary medicine are discussed, trying to identify present and future markers of intestinal health in poultry. The most promising new biomarkers will be stable molecules ending up in the feces and litter that can be quantified, preferably using rapid and simple pen-side tests. It is unlikely, however, that a single biomarker will be sufficient to follow up all aspects of intestinal health. Combinations of multiple biomarkers and/or metabarcoding, metagenomic, metatranscriptomic, metaproteomic and metabolomic approaches will be the way to go in the future. Candidate biomarkers currently are being investigated by many research groups, but the validation will be a major challenge, due to the complexity of intestinal health in the field.
Keywords
INFLAMMATORY-BOWEL-DISEASE, GUT MICROBIOTA, BROILER-CHICKENS, PROTEIN FERMENTATION, ULCERATIVE-COLITIS, GROWTH PROMOTERS, BARRIER FUNCTION, CROHNS-DISEASE, LIPOPOLYSACCHARIDE, PERMEABILITY

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Please use this url to cite or link to this publication:

Chicago
Ducatelle, Richard, Evy Goossens, Fien De Meyer, Venessa Eeckhaut, Gunther Antonissen, Freddy Haesebrouck, and Filip Van Immerseel. 2018. “Biomarkers for Monitoring Intestinal Health in Poultry : Present Status and Future Perspectives.” Veterinary Research 49.
APA
Ducatelle, Richard, Goossens, E., De Meyer, F., Eeckhaut, V., Antonissen, G., Haesebrouck, F., & Van Immerseel, F. (2018). Biomarkers for monitoring intestinal health in poultry : present status and future perspectives. VETERINARY RESEARCH, 49.
Vancouver
1.
Ducatelle R, Goossens E, De Meyer F, Eeckhaut V, Antonissen G, Haesebrouck F, et al. Biomarkers for monitoring intestinal health in poultry : present status and future perspectives. VETERINARY RESEARCH. 2018;49.
MLA
Ducatelle, Richard, Evy Goossens, Fien De Meyer, et al. “Biomarkers for Monitoring Intestinal Health in Poultry : Present Status and Future Perspectives.” VETERINARY RESEARCH 49 (2018): n. pag. Print.
@article{8561537,
  abstract     = {Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the intestinal microbiome (dysbiosis), leakage of the mucosal barrier and/or inflammation. Since the ban on growth promoting antimicrobials in animal feed, these dysbiosis-related problems have become a major issue, especially in intensive animal farming. The economical and animal welfare consequences are considerable. Consequently, there is a need for continuous monitoring of the intestinal health status, particularly in intensively reared animals, where the intestinal function is often pushed to the limit. In the current review, the recent advances in the field of intestinal health biomarkers, both in human and veterinary medicine are discussed, trying to identify present and future markers of intestinal health in poultry. The most promising new biomarkers will be stable molecules ending up in the feces and litter that can be quantified, preferably using rapid and simple pen-side tests. It is unlikely, however, that a single biomarker will be sufficient to follow up all aspects of intestinal health. Combinations of multiple biomarkers and/or metabarcoding, metagenomic, metatranscriptomic, metaproteomic and metabolomic approaches will be the way to go in the future. Candidate biomarkers currently are being investigated by many research groups, but the validation will be a major challenge, due to the complexity of intestinal health in the field.},
  articleno    = {43},
  author       = {Ducatelle, Richard and Goossens, Evy and De Meyer, Fien and Eeckhaut, Venessa and Antonissen, Gunther and Haesebrouck, Freddy and Van Immerseel, Filip},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  keyword      = {INFLAMMATORY-BOWEL-DISEASE,GUT MICROBIOTA,BROILER-CHICKENS,PROTEIN FERMENTATION,ULCERATIVE-COLITIS,GROWTH PROMOTERS,BARRIER FUNCTION,CROHNS-DISEASE,LIPOPOLYSACCHARIDE,PERMEABILITY},
  language     = {eng},
  pages        = {9},
  title        = {Biomarkers for monitoring intestinal health in poultry : present status and future perspectives},
  url          = {http://dx.doi.org/10.1186/s13567-018-0538-6},
  volume       = {49},
  year         = {2018},
}

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