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Intratumoral chemotherapy in an integumentary squamous cell carcinoma in a cockatiel (Nymphicus hollandicus)

Naomi Van Hecke, An Martel UGent, An Garmyn UGent, Isabel Van de Maele UGent, Tom Hellebuyck UGent, Siska Croubels UGent, Richard Ducatelle UGent and Gunther Antonissen UGent (2018) VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 87(2). p.86-92
abstract
An eight-year-old, female cockatiel (Nymphicus hollandicus) was presented with anorexia, lethargy, a mass at the lower side of the wing and discoloration of the feathers. Physical examination showed an ulcerated nodular integumentary lesion of approximately 4 cm(3) ventromedial on the wing at the side of the propatagium and the humerus. Lateral and ventrodorsal radiographs revealed only hepatomegaly. After a stabilization period, surgical excision of the tumor was performed. Based on histopathological evaluation and bacterial culture of the surgically removed tissue, the lesion was typed as an integumentary squamous cell carcinoma with secondary bacterial infection (Corynebacterium sp). Four weeks postoperative, the tumor had recurred. Chemotherapeutic treatment was started with intratumoral carboplatin (1.5 mg/cm(3)) once a week. Because of further tumor growth after the second administration of carboplatin, resection of the mass was performed before the next infiltration. However, the bird died during anesthesia. Despite increase in tumor size, histopathological and immunohistochemical evaluations showed degeneration of the tumor with intercellular edema and vacuolization of the tumor cells, presumably resulting from carboplatin administration. More research is needed to investigate the efficacy and safety of the intratumoral administration of carboplatin as a treatment option in birds with integumentary squamous cell carcinoma.
Please use this url to cite or link to this publication:
author
organization
alternative title
Intratumorale chemotherapie van een plaveicelcarcinoom van de huid bij een valkparkiet (Nymphicus hollandicus)
year
type
journalArticle (original)
publication status
published
subject
keyword
CACATUA-GALERITA, CARBOPLATIN, BIRDS, PHARMACOKINETICS, INFUSION, DISEASES, DRUGS, TUMOR
journal title
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vlaams Diergeneesk. Tijdschr.
volume
87
issue
2
pages
86 - 92
Web of Science type
Article
Web of Science id
000432438200004
ISSN
0303-9021
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
8561534
handle
http://hdl.handle.net/1854/LU-8561534
date created
2018-05-13 13:48:59
date last changed
2018-06-06 08:32:16
@article{8561534,
  abstract     = {An eight-year-old, female cockatiel (Nymphicus hollandicus) was presented with anorexia, lethargy, a mass at the lower side of the wing and discoloration of the feathers. Physical examination showed an ulcerated nodular integumentary lesion of approximately 4 cm(3) ventromedial on the wing at the side of the propatagium and the humerus. Lateral and ventrodorsal radiographs revealed only hepatomegaly. After a stabilization period, surgical excision of the tumor was performed. Based on histopathological evaluation and bacterial culture of the surgically removed tissue, the lesion was typed as an integumentary squamous cell carcinoma with secondary bacterial infection (Corynebacterium sp). Four weeks postoperative, the tumor had recurred. Chemotherapeutic treatment was started with intratumoral carboplatin (1.5 mg/cm(3)) once a week. Because of further tumor growth after the second administration of carboplatin, resection of the mass was performed before the next infiltration. However, the bird died during anesthesia. Despite increase in tumor size, histopathological and immunohistochemical evaluations showed degeneration of the tumor with intercellular edema and vacuolization of the tumor cells, presumably resulting from carboplatin administration. More research is needed to investigate the efficacy and safety of the intratumoral administration of carboplatin as a treatment option in birds with integumentary squamous cell carcinoma.},
  author       = {Van Hecke, Naomi and Martel, An and Garmyn, An and Van de Maele, Isabel and Hellebuyck, Tom and Croubels, Siska and Ducatelle, Richard and Antonissen, Gunther},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {CACATUA-GALERITA,CARBOPLATIN,BIRDS,PHARMACOKINETICS,INFUSION,DISEASES,DRUGS,TUMOR},
  language     = {eng},
  number       = {2},
  pages        = {86--92},
  title        = {Intratumoral chemotherapy in an integumentary squamous cell carcinoma in a cockatiel (Nymphicus hollandicus)},
  volume       = {87},
  year         = {2018},
}

Chicago
Van Hecke, Naomi, An Martel, An Garmyn, Isabel Van de Maele, Tom Hellebuyck, Siska Croubels, Richard Ducatelle, and Gunther Antonissen. 2018. “Intratumoral Chemotherapy in an Integumentary Squamous Cell Carcinoma in a Cockatiel (Nymphicus Hollandicus).” Vlaams Diergeneeskundig Tijdschrift 87 (2): 86–92.
APA
Van Hecke, Naomi, Martel, A., Garmyn, A., Van de Maele, I., Hellebuyck, T., Croubels, S., Ducatelle, R., et al. (2018). Intratumoral chemotherapy in an integumentary squamous cell carcinoma in a cockatiel (Nymphicus hollandicus). VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 87(2), 86–92.
Vancouver
1.
Van Hecke N, Martel A, Garmyn A, Van de Maele I, Hellebuyck T, Croubels S, et al. Intratumoral chemotherapy in an integumentary squamous cell carcinoma in a cockatiel (Nymphicus hollandicus). VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2018;87(2):86–92.
MLA
Van Hecke, Naomi, An Martel, An Garmyn, et al. “Intratumoral Chemotherapy in an Integumentary Squamous Cell Carcinoma in a Cockatiel (Nymphicus Hollandicus).” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 87.2 (2018): 86–92. Print.