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Micro-computed tomography for the quantification of blocked fibers in hemodialyzers

Floris Vanommeslaeghe (UGent) , Wim Van Biesen (UGent) , Manuel Dierick (UGent) , Matthieu Boone (UGent) , Annemieke Dhondt (UGent) and Sunny Eloot (UGent)
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Abstract
A novel technique based on micro-CT scanning is developed to quantify coagulation in fibers of hemodialyzers. This objectivation is needed to allow accurate assessment of thrombogenicity of dialyzers used during hemodialysis, for example when comparing different strategies to avoid coagulation and/or fiber blocking. The protocol allowed imaging at a resolution of 25 mu m, making it possible to count the open, non-coagulated fibers in a non-invasive way. In 3 fresh, non-used FX600 hemodialyzers, patent fiber counts were extremely consistent (10748 +/- 2). To illustrate the potential of this technique, different dialysis parameters currently used as surrogates for fiber blocking were evaluated during 20 hemodialysis sessions. After dialysis, the FX600 dialyzers were visually scored for clotting, dried and subsequently weighed and scanned. The number of patent fibers (10003 [ 8763,10330], range 534-10692) did not correlate with any of the recorded surrogate parameters. Micro-CT scanning is a feasible, objective, non-invasive, accurate and reproducible tool for quantification of the degree of fiber blocking in a hemodialyzer after use, making it a potential gold standard for use in studies on fiber blocking during renal replacement therapies.
Keywords
REGIONAL CITRATE ANTICOAGULATION, MAINTENANCE HEMODIALYSIS, SOFTWARE TOOLS, IMAGE-ANALYSIS, BUNDLE VOLUME, MEMBRANE, HEPARIN, DIALYSATE, PLATFORM, TRIAL

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Chicago
Vanommeslaeghe, Floris, Wim Van Biesen, Manuel Dierick, Matthieu Boone, Annemieke Dhondt, and Sunny Eloot. 2018. “Micro-computed Tomography for the Quantification of Blocked Fibers in Hemodialyzers.” Scientific Reports 8.
APA
Vanommeslaeghe, F., Van Biesen, W., Dierick, M., Boone, M., Dhondt, A., & Eloot, S. (2018). Micro-computed tomography for the quantification of blocked fibers in hemodialyzers. SCIENTIFIC REPORTS, 8.
Vancouver
1.
Vanommeslaeghe F, Van Biesen W, Dierick M, Boone M, Dhondt A, Eloot S. Micro-computed tomography for the quantification of blocked fibers in hemodialyzers. SCIENTIFIC REPORTS. 2018;8.
MLA
Vanommeslaeghe, Floris, Wim Van Biesen, Manuel Dierick, et al. “Micro-computed Tomography for the Quantification of Blocked Fibers in Hemodialyzers.” SCIENTIFIC REPORTS 8 (2018): n. pag. Print.
@article{8561410,
  abstract     = {A novel technique based on micro-CT scanning is developed to quantify coagulation in fibers of hemodialyzers. This objectivation is needed to allow accurate assessment of thrombogenicity of dialyzers used during hemodialysis, for example when comparing different strategies to avoid coagulation and/or fiber blocking. The protocol allowed imaging at a resolution of 25 mu m, making it possible to count the open, non-coagulated fibers in a non-invasive way. In 3 fresh, non-used FX600 hemodialyzers, patent fiber counts were extremely consistent (10748 +/- 2). To illustrate the potential of this technique, different dialysis parameters currently used as surrogates for fiber blocking were evaluated during 20 hemodialysis sessions. After dialysis, the FX600 dialyzers were visually scored for clotting, dried and subsequently weighed and scanned. The number of patent fibers (10003 [ 8763,10330], range 534-10692) did not correlate with any of the recorded surrogate parameters. Micro-CT scanning is a feasible, objective, non-invasive, accurate and reproducible tool for quantification of the degree of fiber blocking in a hemodialyzer after use, making it a potential gold standard for use in studies on fiber blocking during renal replacement therapies.},
  articleno    = {2677},
  author       = {Vanommeslaeghe, Floris and Van Biesen, Wim and Dierick, Manuel and Boone, Matthieu and Dhondt, Annemieke and Eloot, Sunny},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {REGIONAL CITRATE ANTICOAGULATION,MAINTENANCE HEMODIALYSIS,SOFTWARE TOOLS,IMAGE-ANALYSIS,BUNDLE VOLUME,MEMBRANE,HEPARIN,DIALYSATE,PLATFORM,TRIAL},
  language     = {eng},
  pages        = {9},
  title        = {Micro-computed tomography for the quantification of blocked fibers in hemodialyzers},
  url          = {http://dx.doi.org/10.1038/s41598-018-20898-w},
  volume       = {8},
  year         = {2018},
}

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