- Author
- Johnny Bonnardel (UGent) and Martin Guilliams (UGent)
- Organization
- Abstract
- The combination between novel fate-mapping tools and single cell RNA-sequencing technology has revealed the presence of multiple macrophage progenitors. This raises the fascinating possibility that what was once perceived as immense functional plasticity of macrophages could in fact come down to separate macrophage subsets performing distinct functions because of their differential cellular origin. The question of macrophage plasticity versus macrophage heterogeneity is broader than the difference between macrophages of embryonic or adult hematopoietic origin and is particularly relevant in the context of inflammation. In this manuscript, we review the potential impact of cellular origin on the function of macrophages. We also highlight the need for novel 'functional fate-mapping' tools that would reveal the history of the functional state of macrophages, rather than their cellular origin, in order to finally study their true plasticity in vivo.
- Keywords
- TISSUE-RESIDENT MACROPHAGES, HEMATOPOIETIC STEM-CELLS, COLONY-STIMULATING FACTOR, CENTRAL-NERVOUS-SYSTEM, DENDRITIC CELLS, CIRCULATING MONOCYTES, ALVEOLAR MACROPHAGES, BACTERIAL-INFECTION, LY6C(LOW) MONOCYTES, CARDIAC MACROPHAGES
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8561164
- MLA
- Bonnardel, Johnny, and Martin Guilliams. “Developmental Control of Macrophage Function.” CURRENT OPINION IN IMMUNOLOGY, edited by Gwendalyn J Randolph, vol. 50, 2018, pp. 64–74, doi:10.1016/j.coi.2017.12.001.
- APA
- Bonnardel, J., & Guilliams, M. (2018). Developmental control of macrophage function. CURRENT OPINION IN IMMUNOLOGY, 50, 64–74. https://doi.org/10.1016/j.coi.2017.12.001
- Chicago author-date
- Bonnardel, Johnny, and Martin Guilliams. 2018. “Developmental Control of Macrophage Function.” Edited by Gwendalyn J Randolph. CURRENT OPINION IN IMMUNOLOGY 50: 64–74. https://doi.org/10.1016/j.coi.2017.12.001.
- Chicago author-date (all authors)
- Bonnardel, Johnny, and Martin Guilliams. 2018. “Developmental Control of Macrophage Function.” Ed by. Gwendalyn J Randolph. CURRENT OPINION IN IMMUNOLOGY 50: 64–74. doi:10.1016/j.coi.2017.12.001.
- Vancouver
- 1.Bonnardel J, Guilliams M. Developmental control of macrophage function. Randolph GJ, editor. CURRENT OPINION IN IMMUNOLOGY. 2018;50:64–74.
- IEEE
- [1]J. Bonnardel and M. Guilliams, “Developmental control of macrophage function,” CURRENT OPINION IN IMMUNOLOGY, vol. 50, pp. 64–74, 2018.
@article{8561164,
abstract = {{The combination between novel fate-mapping tools and single cell RNA-sequencing technology has revealed the presence of multiple macrophage progenitors. This raises the fascinating possibility that what was once perceived as immense functional plasticity of macrophages could in fact come down to separate macrophage subsets performing distinct functions because of their differential cellular origin. The question of macrophage plasticity versus macrophage heterogeneity is broader than the difference between macrophages of embryonic or adult hematopoietic origin and is particularly relevant in the context of inflammation. In this manuscript, we review the potential impact of cellular origin on the function of macrophages. We also highlight the need for novel 'functional fate-mapping' tools that would reveal the history of the functional state of macrophages, rather than their cellular origin, in order to finally study their true plasticity in vivo.}},
author = {{Bonnardel, Johnny and Guilliams, Martin}},
editor = {{Randolph, Gwendalyn J}},
issn = {{0952-7915}},
journal = {{CURRENT OPINION IN IMMUNOLOGY}},
keywords = {{TISSUE-RESIDENT MACROPHAGES,HEMATOPOIETIC STEM-CELLS,COLONY-STIMULATING FACTOR,CENTRAL-NERVOUS-SYSTEM,DENDRITIC CELLS,CIRCULATING MONOCYTES,ALVEOLAR MACROPHAGES,BACTERIAL-INFECTION,LY6C(LOW) MONOCYTES,CARDIAC MACROPHAGES}},
language = {{eng}},
pages = {{64--74}},
title = {{Developmental control of macrophage function}},
url = {{http://dx.doi.org/10.1016/j.coi.2017.12.001}},
volume = {{50}},
year = {{2018}},
}
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