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Developmental control of macrophage function

Johnny Bonnardel (UGent) and Martin Guilliams (UGent)
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Abstract
The combination between novel fate-mapping tools and single cell RNA-sequencing technology has revealed the presence of multiple macrophage progenitors. This raises the fascinating possibility that what was once perceived as immense functional plasticity of macrophages could in fact come down to separate macrophage subsets performing distinct functions because of their differential cellular origin. The question of macrophage plasticity versus macrophage heterogeneity is broader than the difference between macrophages of embryonic or adult hematopoietic origin and is particularly relevant in the context of inflammation. In this manuscript, we review the potential impact of cellular origin on the function of macrophages. We also highlight the need for novel 'functional fate-mapping' tools that would reveal the history of the functional state of macrophages, rather than their cellular origin, in order to finally study their true plasticity in vivo.
Keywords
TISSUE-RESIDENT MACROPHAGES, HEMATOPOIETIC STEM-CELLS, COLONY-STIMULATING FACTOR, CENTRAL-NERVOUS-SYSTEM, DENDRITIC CELLS, CIRCULATING MONOCYTES, ALVEOLAR MACROPHAGES, BACTERIAL-INFECTION, LY6C(LOW) MONOCYTES, CARDIAC MACROPHAGES

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Citation

Please use this url to cite or link to this publication:

Chicago
Bonnardel, Johnny, and Martin Guilliams. 2018. “Developmental Control of Macrophage Function.” Ed. Gwendalyn J Randolph. Current Opinion in Immunology 50: 64–74.
APA
Bonnardel, J., & Guilliams, M. (2018). Developmental control of macrophage function. (G. J. Randolph, Ed.)CURRENT OPINION IN IMMUNOLOGY, 50, 64–74.
Vancouver
1.
Bonnardel J, Guilliams M. Developmental control of macrophage function. Randolph GJ, editor. CURRENT OPINION IN IMMUNOLOGY. 2018;50:64–74.
MLA
Bonnardel, Johnny, and Martin Guilliams. “Developmental Control of Macrophage Function.” Ed. Gwendalyn J Randolph. CURRENT OPINION IN IMMUNOLOGY 50 (2018): 64–74. Print.
@article{8561164,
  abstract     = {The combination between novel fate-mapping tools and single cell RNA-sequencing technology has revealed the presence of multiple macrophage progenitors. This raises the fascinating possibility that what was once perceived as immense functional plasticity of macrophages could in fact come down to separate macrophage subsets performing distinct functions because of their differential cellular origin. The question of macrophage plasticity versus macrophage heterogeneity is broader than the difference between macrophages of embryonic or adult hematopoietic origin and is particularly relevant in the context of inflammation. In this manuscript, we review the potential impact of cellular origin on the function of macrophages. We also highlight the need for novel 'functional fate-mapping' tools that would reveal the history of the functional state of macrophages, rather than their cellular origin, in order to finally study their true plasticity in vivo.},
  author       = {Bonnardel, Johnny and Guilliams, Martin},
  editor       = {Randolph, Gwendalyn J},
  issn         = {0952-7915},
  journal      = {CURRENT OPINION IN IMMUNOLOGY},
  language     = {eng},
  pages        = {64--74},
  title        = {Developmental control of macrophage function},
  url          = {http://dx.doi.org/10.1016/j.coi.2017.12.001},
  volume       = {50},
  year         = {2018},
}

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