Advanced search
1 file | 1.33 MB

The 'COmorBidity in Relation to AIDS' (COBRA) cohort : design, methods and participant characteristics

(2018) PLOS ONE. 13(3).
Author
Organization
Abstract
Background : Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging. Objective : The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls. Methods : Longitudinal cohort study of HIV-positive subjects >= 45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years. Results : Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM. Conclusions : The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.
Keywords
HIV-INFECTION, ANTIRETROVIRAL THERAPY, LIFE EXPECTANCY, MORTALITY, PEOPLE, PREVENTION, DIAGNOSIS, MORBIDITY, DISEASE

Downloads

  • 3036 18DeFrancesco.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 1.33 MB

Citation

Please use this url to cite or link to this publication:

Chicago
De Francesco, Davide, Ferdinand W Wit, James H Cole, Neeltje A Kootstra, Alan Winston, Caroline A Sabin, Jonathan Underwood, et al. 2018. “The ‘COmorBidity in Relation to AIDS’ (COBRA) Cohort : Design, Methods and Participant Characteristics.” Plos One 13 (3).
APA
De Francesco, D., Wit, F. W., Cole, J. H., Kootstra, N. A., Winston, A., Sabin, C. A., Underwood, J., et al. (2018). The “COmorBidity in Relation to AIDS” (COBRA) cohort : design, methods and participant characteristics. PLOS ONE, 13(3).
Vancouver
1.
De Francesco D, Wit FW, Cole JH, Kootstra NA, Winston A, Sabin CA, et al. The “COmorBidity in Relation to AIDS” (COBRA) cohort : design, methods and participant characteristics. PLOS ONE. 2018;13(3).
MLA
De Francesco, Davide, Ferdinand W Wit, James H Cole, et al. “The ‘COmorBidity in Relation to AIDS’ (COBRA) Cohort : Design, Methods and Participant Characteristics.” PLOS ONE 13.3 (2018): n. pag. Print.
@article{8561161,
  abstract     = {Background : Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging. 
Objective : The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls. 
Methods : Longitudinal cohort study of HIV-positive subjects {\textrangle}= 45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years. 
Results : Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93\% were male, 88\% of white ethnicity and 86\% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92\% were male, 97\% of white ethnicity and 80\% were MSM. 
Conclusions : The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.},
  articleno    = {e0191791},
  author       = {De Francesco, Davide and Wit, Ferdinand W and Cole, James H and Kootstra, Neeltje A and Winston, Alan and Sabin, Caroline A and Underwood, Jonathan and van Zoest, Rosan A and Schouten, Judith and Kooij, Katherine W and Prins, Maria and Guaraldi, Giovanni and Caan, Matthan WA and Burger, David and Franceschi, Claudio and Libert, Claude and Buerkie, Alexander and Reiss, Peter},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  language     = {eng},
  number       = {3},
  pages        = {16},
  title        = {The 'COmorBidity in Relation to AIDS' (COBRA) cohort : design, methods and participant characteristics},
  url          = {http://dx.doi.org/10.1371/journal.pone.0191791},
  volume       = {13},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: