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Polycaprolactone-b-poly(N-isopropylacrylamide) nanoparticles : synthesis and temperature induced coacervation behavior

(2018) EUROPEAN POLYMER JOURNAL. 98. p.468-474
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Abstract
Poly(caprolactone)-b-poly(N-isopropylacrylamide) (PCL-b-PNIPAM) copolymers were prepared with different compositions of the individual blocks using a combination of enzyme catalyzed anionic ring opening (AROP) polymerization, reversible addition fragmentation chain transfer (RAFT) polymerization and triazolinedionediene click chemistry. Study of the self-assembly of these block copolymers at different temperatures demonstrates the formation of nanoparticles, characterized by a thermo-responsive behavior that is strongly dependent on the PNIPAM block length. At elevated temperature, self-aggregation (coacervation) of the nanoparticles could occur, leading to the formation of larger polymer aggregates.
Keywords
ISOPROPYLACRYLAMIDE TRIBLOCK COPOLYMERS, RING-OPENING POLYMERIZATION, DRUG-DELIVERY, BLOCK-COPOLYMERS, CLICK CHEMISTRY, RAFT POLYMERIZATION, GRAFT-COPOLYMERS, MICELLES, POLYMERS, DESIGN, Amphiphilic block copolymers, Click chemistry, Triazolinediones, Self-assembly

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Citation

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Chicago
Vandewalle, Stef, M Van De Walle, Subrata Chattopadhyay, and Filip Du Prez. 2018. “Polycaprolactone-b-poly(N-isopropylacrylamide) Nanoparticles : Synthesis and Temperature Induced Coacervation Behavior.” European Polymer Journal 98: 468–474.
APA
Vandewalle, Stef, Van De Walle, M., Chattopadhyay, S., & Du Prez, F. (2018). Polycaprolactone-b-poly(N-isopropylacrylamide) nanoparticles : synthesis and temperature induced coacervation behavior. EUROPEAN POLYMER JOURNAL, 98, 468–474.
Vancouver
1.
Vandewalle S, Van De Walle M, Chattopadhyay S, Du Prez F. Polycaprolactone-b-poly(N-isopropylacrylamide) nanoparticles : synthesis and temperature induced coacervation behavior. EUROPEAN POLYMER JOURNAL. 2018;98:468–74.
MLA
Vandewalle, Stef, M Van De Walle, Subrata Chattopadhyay, et al. “Polycaprolactone-b-poly(N-isopropylacrylamide) Nanoparticles : Synthesis and Temperature Induced Coacervation Behavior.” EUROPEAN POLYMER JOURNAL 98 (2018): 468–474. Print.
@article{8561124,
  abstract     = {Poly(caprolactone)-b-poly(N-isopropylacrylamide) (PCL-b-PNIPAM) copolymers were prepared with different compositions of the individual blocks using a combination of enzyme catalyzed anionic ring opening (AROP) polymerization, reversible addition fragmentation chain transfer (RAFT) polymerization and triazolinedionediene click chemistry. Study of the self-assembly of these block copolymers at different temperatures demonstrates the formation of nanoparticles, characterized by a thermo-responsive behavior that is strongly dependent on the PNIPAM block length. At elevated temperature, self-aggregation (coacervation) of the nanoparticles could occur, leading to the formation of larger polymer aggregates.},
  author       = {Vandewalle, Stef and Van De Walle, M and Chattopadhyay, Subrata and Du Prez, Filip},
  issn         = {0014-3057},
  journal      = {EUROPEAN POLYMER JOURNAL},
  language     = {eng},
  pages        = {468--474},
  title        = {Polycaprolactone-b-poly(N-isopropylacrylamide) nanoparticles : synthesis and temperature induced coacervation behavior},
  url          = {http://dx.doi.org/10.1016/j.eurpolymj.2017.11.027},
  volume       = {98},
  year         = {2018},
}

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