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Sensory prediction errors are less modulated by global context in autism spectrum disorder

Judith Goris (UGent) , Senne Braem (UGent) , dr. Annabel Nijhof (UGent) , Davide Rigoni (UGent) , Eliane Deschrijver (UGent) , Sander Van de Cruys, Roeljan Wiersema (UGent) and Marcel Brass (UGent)
(2018) BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 3(8). p.667-674
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Abstract
BACKGROUND: Recent predictive coding accounts of autism spectrum disorder (ASD) suggest that a key deficit in ASD concerns the inflexibility in modulating local prediction errors as a function of global top-down expectations. As a direct test of this central hypothesis, we used electroencephalography to investigate whether local prediction error processing was less modulated by global context (i.e., global stimulus frequency) in ASD. METHODS: A group of 18 adults with ASD was compared with a group of 24 typically developed adults on a well-validated hierarchical auditory oddball task in which participants listened to short sequences of either five identical sounds (local standard) or four identical sounds and a fifth deviant sound (local deviant). The latter condition is known to generate the mismatch negativity (MMN) component, believed to reflect early sensory prediction error processing. Crucially, previous studies have shown that in blocks with a higher frequency of local deviant sequences, top-down expectations seem to attenuate the MMN. We predicted that this modulation by global context would be less pronounced in the ASD group. RESULTS: Both groups showed an MMN that was modulated by global context. However, this effect was smaller in the ASD group as compared with the typically developed group. In contrast, the P3b, as an electroencephalographic marker of conscious expectation processes, did not differ across groups. CONCLUSIONS: Our results demonstrate that people with ASD are less flexible in modulating their local predictions (reflected in MMN), thereby confirming the central hypothesis of contemporary predictive coding accounts of ASD.
Keywords
ASD, Autism, EEG, Mismatch negativity (MMN), Prediction error, Predictive coding, EVENT-RELATED POTENTIALS, MISMATCH NEGATIVITY MMN, FUNCTIONING AUTISM, ASPERGER-SYNDROME, QUOTIENT AQ, CHILDREN, ATTENTION, SPEECH, ADULTS, INTERFERENCE

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MLA
Goris, Judith, et al. “Sensory Prediction Errors Are Less Modulated by Global Context in Autism Spectrum Disorder.” BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING, vol. 3, no. 8, 2018, pp. 667–74, doi:10.1016/j.bpsc.2018.02.003.
APA
Goris, J., Braem, S., Nijhof, dr. A., Rigoni, D., Deschrijver, E., Van de Cruys, S., … Brass, M. (2018). Sensory prediction errors are less modulated by global context in autism spectrum disorder. BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 3(8), 667–674. https://doi.org/10.1016/j.bpsc.2018.02.003
Chicago author-date
Goris, Judith, Senne Braem, dr. Annabel Nijhof, Davide Rigoni, Eliane Deschrijver, Sander Van de Cruys, Roeljan Wiersema, and Marcel Brass. 2018. “Sensory Prediction Errors Are Less Modulated by Global Context in Autism Spectrum Disorder.” BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING 3 (8): 667–74. https://doi.org/10.1016/j.bpsc.2018.02.003.
Chicago author-date (all authors)
Goris, Judith, Senne Braem, dr. Annabel Nijhof, Davide Rigoni, Eliane Deschrijver, Sander Van de Cruys, Roeljan Wiersema, and Marcel Brass. 2018. “Sensory Prediction Errors Are Less Modulated by Global Context in Autism Spectrum Disorder.” BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING 3 (8): 667–674. doi:10.1016/j.bpsc.2018.02.003.
Vancouver
1.
Goris J, Braem S, Nijhof dr. A, Rigoni D, Deschrijver E, Van de Cruys S, et al. Sensory prediction errors are less modulated by global context in autism spectrum disorder. BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2018;3(8):667–74.
IEEE
[1]
J. Goris et al., “Sensory prediction errors are less modulated by global context in autism spectrum disorder,” BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING, vol. 3, no. 8, pp. 667–674, 2018.
@article{8560969,
  abstract     = {{BACKGROUND: Recent predictive coding accounts of autism spectrum disorder (ASD) suggest that a key deficit in ASD concerns the inflexibility in modulating local prediction errors as a function of global top-down expectations. As a direct test of this central hypothesis, we used electroencephalography to investigate whether local prediction error processing was less modulated by global context (i.e., global stimulus frequency) in ASD.
METHODS: A group of 18 adults with ASD was compared with a group of 24 typically developed adults on a well-validated hierarchical auditory oddball task in which participants listened to short sequences of either five identical sounds (local standard) or four identical sounds and a fifth deviant sound (local deviant). The latter condition is known to generate the mismatch negativity (MMN) component, believed to reflect early sensory prediction error processing. Crucially, previous studies have shown that in blocks with a higher frequency of local deviant sequences, top-down expectations seem to attenuate the MMN. We predicted that this modulation by global context would be less pronounced in the ASD group.
RESULTS: Both groups showed an MMN that was modulated by global context. However, this effect was smaller in the ASD group as compared with the typically developed group. In contrast, the P3b, as an electroencephalographic marker of conscious expectation processes, did not differ across groups.
CONCLUSIONS: Our results demonstrate that people with ASD are less flexible in modulating their local predictions (reflected in MMN), thereby confirming the central hypothesis of contemporary predictive coding accounts of ASD.}},
  author       = {{Goris, Judith and Braem, Senne and Nijhof, dr. Annabel and Rigoni, Davide and Deschrijver, Eliane and Van de Cruys, Sander and Wiersema, Roeljan and Brass, Marcel}},
  issn         = {{2451-9022}},
  journal      = {{BIOLOGICAL PSYCHIATRY : COGNITIVE NEUROSCIENCE AND NEUROIMAGING}},
  keywords     = {{ASD,Autism,EEG,Mismatch negativity (MMN),Prediction error,Predictive coding,EVENT-RELATED POTENTIALS,MISMATCH NEGATIVITY MMN,FUNCTIONING AUTISM,ASPERGER-SYNDROME,QUOTIENT AQ,CHILDREN,ATTENTION,SPEECH,ADULTS,INTERFERENCE}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{667--674}},
  title        = {{Sensory prediction errors are less modulated by global context in autism spectrum disorder}},
  url          = {{http://doi.org/10.1016/j.bpsc.2018.02.003}},
  volume       = {{3}},
  year         = {{2018}},
}
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