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Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours

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Abstract
For the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside). Twenty volunteers were restricted in consuming cereals and cereal-based foods for 4 days. At day 3, a single bolus of 1 mu g/kg body weight of DON and a single bolus of 1 mu g/kg body weight of DON-3-glucoside after a washing-out period of two months was administered, and a 24-h urine collection was performed. The urine was analysed for DON, DON-3-glucoside, 3-ADON, 15-ADON, deepoxy-deoxynivalenol (DOM-1), deoxynivalenol-3-glucuronide (DON-3-glucuronide) and deoxynivalenol-15-glucuronide (DON-15-glucuronide). The urinary biomarker-analysis revealed that DON and DON-3-glucoside were rapidly absorbed, distributed, metabolized and excreted. Sixty-four % of the administered DON and 58% of DON-3-glucoside was recovered in the urine collected within 24 h. DON-15-glucuronide was the most prominent urinary biomarker followed by free DON and DON-3-glucuronide. Moreover, correlations among the presence of DON-15-glucuronide and DON-3-glucuronide were observed (within 24 hours (r = 0.61)). The DOM-1 detected in the urine was higher after the DON-3-glucoside administration. The obtained results are imperative to construct a standardized method to estimate DON-intake by means of urinary biomarkers.
Keywords
LC-MS/MS, MASKED FORMS, URINARY DEOXYNIVALENOL, ORAL BIOAVAILABILITY, BROILER-CHICKENS, T-2 TOXIN, EXPOSURE, ZEARALENONE, BIOMARKER, FOOD

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Chicago
Vidal Corominas, Arnau, Liesel Claeys, Marcel Mengelers, Valérie Vanhoorne, Chris Vervaet, Bart Huybrechts, Sarah De Saeger, and Marthe De Boevre. 2018. “Humans Significantly Metabolize and Excrete the Mycotoxin Deoxynivalenol and Its Modified Form Deoxynivalenol-3-glucoside Within 24 Hours.” Scientific Reports 8.
APA
Vidal Corominas, A., Claeys, L., Mengelers, M., Vanhoorne, V., Vervaet, C., Huybrechts, B., De Saeger, S., et al. (2018). Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. SCIENTIFIC REPORTS, 8.
Vancouver
1.
Vidal Corominas A, Claeys L, Mengelers M, Vanhoorne V, Vervaet C, Huybrechts B, et al. Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. SCIENTIFIC REPORTS. 2018;8.
MLA
Vidal Corominas, Arnau, Liesel Claeys, Marcel Mengelers, et al. “Humans Significantly Metabolize and Excrete the Mycotoxin Deoxynivalenol and Its Modified Form Deoxynivalenol-3-glucoside Within 24 Hours.” SCIENTIFIC REPORTS 8 (2018): n. pag. Print.
@article{8559815,
  abstract     = {For the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside). Twenty volunteers were restricted in consuming cereals and cereal-based foods for 4 days. At day 3, a single bolus of 1 mu g/kg body weight of DON and a single bolus of 1 mu g/kg body weight of DON-3-glucoside after a washing-out period of two months was administered, and a 24-h urine collection was performed. The urine was analysed for DON, DON-3-glucoside, 3-ADON, 15-ADON, deepoxy-deoxynivalenol (DOM-1), deoxynivalenol-3-glucuronide (DON-3-glucuronide) and deoxynivalenol-15-glucuronide (DON-15-glucuronide). The urinary biomarker-analysis revealed that DON and DON-3-glucoside were rapidly absorbed, distributed, metabolized and excreted. Sixty-four \% of the administered DON and 58\% of DON-3-glucoside was recovered in the urine collected within 24 h. DON-15-glucuronide was the most prominent urinary biomarker followed by free DON and DON-3-glucuronide. Moreover, correlations among the presence of DON-15-glucuronide and DON-3-glucuronide were observed (within 24 hours (r = 0.61)). The DOM-1 detected in the urine was higher after the DON-3-glucoside administration. The obtained results are imperative to construct a standardized method to estimate DON-intake by means of urinary biomarkers.},
  articleno    = {5255},
  author       = {Vidal Corominas, Arnau and Claeys, Liesel and Mengelers, Marcel and Vanhoorne, Val{\'e}rie and Vervaet, Chris and Huybrechts, Bart and De Saeger, Sarah and De Boevre, Marthe},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  language     = {eng},
  pages        = {11},
  title        = {Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours},
  url          = {http://dx.doi.org/10.1038/s41598-018-23526-9},
  volume       = {8},
  year         = {2018},
}

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