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Myositis ossificans : another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst

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Abstract
Myositis ossificans is defined as a self-limiting pseudotumor composed of reactive hypercellular fibrous tissue and bone. USP6 rearrangements have been identified as a consistent genetic driving event in aneurysmal bone cyst and nodular fasciitis. It is therefore an integral part of the diagnostic workup when dealing with (myo)fibroblastic lesions of soft tissue and bone. Two cases of myositis ossificans with USP6 rearrangement were published so far. We determine herein the incidence of USP6 rearrangement in myositis ossificans using USP6 fluorescence in situ hybridization analysis (FISH). Of the 11 cases included, seven patients were female and four were male. Age ranged from 6 to 56 years (mean 27 years). Lesions were located in the thigh (n = 5), knee (n = 1), lower leg (n = 1), lower arm (n = 1), perineum (n = 1), gluteal (n = 1) and thoracic wall (n = 1). All assessable cases except one (8/9) showed rearrangement of USP6 providing evidence that myositis ossificans is genetically related to nodular fasciitis and aneurysmal bone cyst.
Keywords
USP6 rearrangement, Myositis ossificans, Soft tissue tumors, SOFT-TISSUE, ONCOGENE, FUSIONS

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Chicago
Bekers, Elise M, Astrid Eijkelenboom, Katrien Grünberg, Rona C Roverts, Jacky WJ de Rooy, Ingrid CM van der Geest, Joost M van Gorp, David Creytens, and Uta Flucke. 2018. “Myositis Ossificans : Another Condition with USP6 Rearrangement, Providing Evidence of a Relationship with Nodular Fasciitis and Aneurysmal Bone Cyst.” Annals of Diagnostic Pathology 34: 56–59.
APA
Bekers, E. M., Eijkelenboom, A., Grünberg, K., Roverts, R. C., de Rooy, J. W., van der Geest, I. C., van Gorp, J. M., et al. (2018). Myositis ossificans : another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst. ANNALS OF DIAGNOSTIC PATHOLOGY, 34, 56–59.
Vancouver
1.
Bekers EM, Eijkelenboom A, Grünberg K, Roverts RC, de Rooy JW, van der Geest IC, et al. Myositis ossificans : another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst. ANNALS OF DIAGNOSTIC PATHOLOGY. 2018;34:56–9.
MLA
Bekers, Elise M, Astrid Eijkelenboom, Katrien Grünberg, et al. “Myositis Ossificans : Another Condition with USP6 Rearrangement, Providing Evidence of a Relationship with Nodular Fasciitis and Aneurysmal Bone Cyst.” ANNALS OF DIAGNOSTIC PATHOLOGY 34 (2018): 56–59. Print.
@article{8559797,
  abstract     = {Myositis ossificans is defined as a self-limiting pseudotumor composed of reactive hypercellular fibrous tissue and bone. 
USP6 rearrangements have been identified as a consistent genetic driving event in aneurysmal bone cyst and nodular fasciitis. It is therefore an integral part of the diagnostic workup when dealing with (myo)fibroblastic lesions of soft tissue and bone. Two cases of myositis ossificans with USP6 rearrangement were published so far. 
We determine herein the incidence of USP6 rearrangement in myositis ossificans using USP6 fluorescence in situ hybridization analysis (FISH). Of the 11 cases included, seven patients were female and four were male. Age ranged from 6 to 56 years (mean 27 years). Lesions were located in the thigh (n = 5), knee (n = 1), lower leg (n = 1), lower arm (n = 1), perineum (n = 1), gluteal (n = 1) and thoracic wall (n = 1). 
All assessable cases except one (8/9) showed rearrangement of USP6 providing evidence that myositis ossificans is genetically related to nodular fasciitis and aneurysmal bone cyst.},
  author       = {Bekers, Elise M and Eijkelenboom, Astrid and Gr{\"u}nberg, Katrien and Roverts, Rona C and de Rooy, Jacky WJ and van der Geest, Ingrid CM and van Gorp, Joost M and Creytens, David and Flucke, Uta},
  issn         = {1092-9134},
  journal      = {ANNALS OF DIAGNOSTIC PATHOLOGY},
  keyword      = {USP6 rearrangement,Myositis ossificans,Soft tissue tumors,SOFT-TISSUE,ONCOGENE,FUSIONS},
  language     = {eng},
  pages        = {56--59},
  title        = {Myositis ossificans : another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst},
  url          = {http://dx.doi.org/10.1016/j.anndiagpath.2018.01.006},
  volume       = {34},
  year         = {2018},
}

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