Advanced search
1 file | 1.32 MB

Anti-MDA5 positive dermatomyositis complicated with rapidly progressive interstitial lung disease : a case report

(2018) ACTA CLINICA BELGICA. 73(6). p.413-417
Author
Organization
Abstract
Case presentation: We present a case of a 55-year-old Caucasian male with manifestations of dermatomyositis complicated with rapidly progressive interstitial lung disease (RP-ILD). Diagnosis of anti-MDA5 positive dermatomyositis was made. Discussion: Myositis specific antibodies (MSA) can be used for diagnosis and predicting prognosis in patients with polymyositis and dermatomyositis. Anti-MDA5 positive dermatomyositis should be considered in patients presenting with dermatomyositis and a disease course resembling antisynthetase syndrome in the absence of antisynthetase autoantibodies, especially if a remarkably high ferritin is noted. Anti-MDA5 autoantibodies have been associated with RP-ILD and adverse outcome. In patients with anti-MDA5 autoantibodies, early diagnosis and aggressive immunosuppressive treatment may improve prognosis. Conclusion: This case highlights the importance of determining MSA in patients with dermatomyositis and associated interstitial lung disease, as this has implications for diagnosis, prognosis and therapy.
Keywords
Dermatomyositis, interstitial lung disease, myositis specific antibodies, anti-MDA5, MYOSITIS-SPECIFIC AUTOANTIBODIES, CLINICAL-SIGNIFICANCE, JAPANESE PATIENTS, ANTIBODY, CADM-140

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.32 MB

Citation

Please use this url to cite or link to this publication:

Chicago
De Backer, Eva, Félix Gremonprez, Guy Brusselle, Pieter Depuydt, Jo Van Dorpe, Carole Van Haverbeke, Pieter Goeminne, and Eric Derom. 2018. “Anti-MDA5 Positive Dermatomyositis Complicated with Rapidly Progressive Interstitial Lung Disease : a Case Report.” Acta Clinica Belgica 73 (6): 413–417.
APA
De Backer, Eva, Gremonprez, F., Brusselle, G., Depuydt, P., Van Dorpe, J., Van Haverbeke, C., Goeminne, P., et al. (2018). Anti-MDA5 positive dermatomyositis complicated with rapidly progressive interstitial lung disease : a case report. ACTA CLINICA BELGICA, 73(6), 413–417.
Vancouver
1.
De Backer E, Gremonprez F, Brusselle G, Depuydt P, Van Dorpe J, Van Haverbeke C, et al. Anti-MDA5 positive dermatomyositis complicated with rapidly progressive interstitial lung disease : a case report. ACTA CLINICA BELGICA. 2018;73(6):413–7.
MLA
De Backer, Eva, Félix Gremonprez, Guy Brusselle, et al. “Anti-MDA5 Positive Dermatomyositis Complicated with Rapidly Progressive Interstitial Lung Disease : a Case Report.” ACTA CLINICA BELGICA 73.6 (2018): 413–417. Print.
@article{8559199,
  abstract     = {Case presentation: We present a case of a 55-year-old Caucasian male with manifestations of dermatomyositis complicated with rapidly progressive interstitial lung disease (RP-ILD). Diagnosis of anti-MDA5 positive dermatomyositis was made.
Discussion: Myositis specific antibodies (MSA) can be used for diagnosis and predicting prognosis in patients with polymyositis and dermatomyositis. Anti-MDA5 positive dermatomyositis should be considered in patients presenting with dermatomyositis and a disease course resembling antisynthetase syndrome in the absence of antisynthetase autoantibodies, especially if a remarkably high ferritin is noted. Anti-MDA5 autoantibodies have been associated with RP-ILD and adverse outcome. In patients with anti-MDA5 autoantibodies, early diagnosis and aggressive immunosuppressive treatment may improve prognosis.
Conclusion: This case highlights the importance of determining MSA in patients with dermatomyositis and associated interstitial lung disease, as this has implications for diagnosis, prognosis and therapy.},
  author       = {De Backer, Eva and Gremonprez, F{\'e}lix and Brusselle, Guy and Depuydt, Pieter and Van Dorpe, Jo and Van Haverbeke, Carole and Goeminne, Pieter and Derom, Eric},
  issn         = {1784-3286},
  journal      = {ACTA CLINICA BELGICA},
  keyword      = {Dermatomyositis,interstitial lung disease,myositis specific antibodies,anti-MDA5,MYOSITIS-SPECIFIC AUTOANTIBODIES,CLINICAL-SIGNIFICANCE,JAPANESE PATIENTS,ANTIBODY,CADM-140},
  language     = {eng},
  number       = {6},
  pages        = {413--417},
  title        = {Anti-MDA5 positive dermatomyositis complicated with rapidly progressive interstitial lung disease : a case report},
  url          = {http://dx.doi.org/10.1080/17843286.2017.1420521},
  volume       = {73},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: