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P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia

Fleur P Paling, Martin Wolkewitz, Pieter Depuydt UGent, Liesbet De Bus UGent, Frangiscos Sifakis, Marc JM Bonten and Jan AJW Kluytmans (2017) ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL. 6(1).
abstract
Objective: To determine the incidence of P. aeruginosa (PA) ICU pneumonia and its independent association with PA colonization at ICU admission. Methods: This was a post-hoc analysis of a prospectively collected cohort study. Adult ICU patients with a length of stay of >= 48 h were included and assessed for microbiologically confirmed PA ICU pneumonia. Multivariate survival analysis was performed, including the covariates age, gender, PA colonization at ICU admission, ICU admission specialty and mechanical ventilation at ICU admission, while taking into account the effect of competing risks. Results: We included 5093 patients, 2447 (48%) were tested for colonization; of those 226 (9.2%) were PA colonized at ICU admission. The incidence of PA ICU pneumonia was 1.34% (n = 68). PA colonization was an independent risk factor (subdistribution hazard ratio [SHR] 8.8; 95% confidence interval [CI] 4.9-15.7), as was mechanical ventilation (SHR 5.3, 95% CI 2.7-10.6). Conclusion: In this study the incidence of P. aeruginosa ICU pneumonia was 1.34%. Hazard ratios for PA colonized patients compared to non-colonized to develop PA ICU pneumonia were 8.8. The high risk associated with P. aeruginosa colonization for subsequent infection may offer a target for future interventions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INTENSIVE-CARE-UNIT, VENTILATOR-ASSOCIATED PNEUMONIA, SURVEILLANCE
journal title
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
Antimicrob. Resist. Infect. Control
volume
6
issue
1
article number
38
pages
3 pages
Web of Science type
Article
Web of Science id
000399756800001
ISSN
2047-2994
DOI
10.1186/s13756-017-0197-9
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8559093
handle
http://hdl.handle.net/1854/LU-8559093
date created
2018-04-16 08:20:35
date last changed
2018-05-15 08:54:59
@article{8559093,
  abstract     = {Objective: To determine the incidence of P. aeruginosa (PA) ICU pneumonia and its independent association with PA colonization at ICU admission. 
Methods: This was a post-hoc analysis of a prospectively collected cohort study. Adult ICU patients with a length of stay of {\textrangle}= 48 h were included and assessed for microbiologically confirmed PA ICU pneumonia. Multivariate survival analysis was performed, including the covariates age, gender, PA colonization at ICU admission, ICU admission specialty and mechanical ventilation at ICU admission, while taking into account the effect of competing risks. 
Results: We included 5093 patients, 2447 (48\%) were tested for colonization; of those 226 (9.2\%) were PA colonized at ICU admission. The incidence of PA ICU pneumonia was 1.34\% (n = 68). PA colonization was an independent risk factor (subdistribution hazard ratio [SHR] 8.8; 95\% confidence interval [CI] 4.9-15.7), as was mechanical ventilation (SHR 5.3, 95\% CI 2.7-10.6). 
Conclusion: In this study the incidence of P. aeruginosa ICU pneumonia was 1.34\%. Hazard ratios for PA colonized patients compared to non-colonized to develop PA ICU pneumonia were 8.8. The high risk associated with P. aeruginosa colonization for subsequent infection may offer a target for future interventions.},
  articleno    = {38},
  author       = {Paling, Fleur P and Wolkewitz, Martin and Depuydt, Pieter and De Bus, Liesbet and Sifakis, Frangiscos and Bonten, Marc JM and Kluytmans, Jan AJW},
  issn         = {2047-2994},
  journal      = {ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL},
  keyword      = {INTENSIVE-CARE-UNIT,VENTILATOR-ASSOCIATED PNEUMONIA,SURVEILLANCE},
  language     = {eng},
  number       = {1},
  pages        = {3},
  title        = {P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia},
  url          = {http://dx.doi.org/10.1186/s13756-017-0197-9},
  volume       = {6},
  year         = {2017},
}

Chicago
Paling, Fleur P, Martin Wolkewitz, Pieter Depuydt, Liesbet De Bus, Frangiscos Sifakis, Marc JM Bonten, and Jan AJW Kluytmans. 2017. “P. Aeruginosa Colonization at ICU Admission as a Risk Factor for Developing P. Aeruginosa ICU Pneumonia.” Antimicrobial Resistance and Infection Control 6 (1).
APA
Paling, Fleur P, Wolkewitz, M., Depuydt, P., De Bus, L., Sifakis, F., Bonten, M. J., & Kluytmans, J. A. (2017). P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia. ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 6(1).
Vancouver
1.
Paling FP, Wolkewitz M, Depuydt P, De Bus L, Sifakis F, Bonten MJ, et al. P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia. ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL. 2017;6(1).
MLA
Paling, Fleur P, Martin Wolkewitz, Pieter Depuydt, et al. “P. Aeruginosa Colonization at ICU Admission as a Risk Factor for Developing P. Aeruginosa ICU Pneumonia.” ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL 6.1 (2017): n. pag. Print.