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Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse

Katrien Smits (UGent) , Sander Willems, Katleen Van Steendam (UGent) , Margot Van de Velde (UGent) , Valérie De Lange, Cyrillus Ververs (UGent) , Kim Roels (UGent) , Jan Govaere (UGent) , Filip Van Nieuwerburgh (UGent) , Luc Peelman (UGent) , et al.
(2018) SCIENTIFIC REPORTS. 8.
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Abstract
During maternal recognition of pregnancy (MRP), a conceptus-derived signal leads to the persistence of the corpus luteum and the maintenance of gestation. In the horse, the nature of this signal remains to be elucidated. Several studies have focused on the changes in gene expression during MRP, but little information exists at the protein level. The aim of this study was to identify the proteins at the embryo-maternal interface around signalling of MRP in the horse (day 13) by means of mass spectrometry. A distinct influence of pregnancy was established, with 119 proteins differentially expressed in the uterine fluid of pregnant mares compared to cyclic mares and with upregulation of several inhibitors of the prostaglandin synthesis during pregnancy. By creating an overview of the proteins at the embryo-maternal interface in the horse, this study provides a solid foundation for further targeted studies of proteins potentially involved in embryo-maternal interactions, MRP and pregnancy loss in the horse.
Keywords
EQUINE ENDOMETRIUM, MASS SPECTROMETRISTS, PROGESTERONE-RECEPTOR, ESTROGEN-RECEPTOR, OXYTOCIN RECEPTOR, MARES, EXPRESSION, PROTEOMICS, PHOSPHOLIPASE-A2, PEPTIDES

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MLA
Smits, Katrien, et al. “Proteins Involved in Embryo-Maternal Interaction around the Signalling of Maternal Recognition of Pregnancy in the Horse.” SCIENTIFIC REPORTS, vol. 8, 2018, doi:10.1038/s41598-018-23537-6.
APA
Smits, K., Willems, S., Van Steendam, K., Van de Velde, M., De Lange, V., Ververs, C., … Van Soom, A. (2018). Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse. SCIENTIFIC REPORTS, 8. https://doi.org/10.1038/s41598-018-23537-6
Chicago author-date
Smits, Katrien, Sander Willems, Katleen Van Steendam, Margot Van de Velde, Valérie De Lange, Cyrillus Ververs, Kim Roels, et al. 2018. “Proteins Involved in Embryo-Maternal Interaction around the Signalling of Maternal Recognition of Pregnancy in the Horse.” SCIENTIFIC REPORTS 8. https://doi.org/10.1038/s41598-018-23537-6.
Chicago author-date (all authors)
Smits, Katrien, Sander Willems, Katleen Van Steendam, Margot Van de Velde, Valérie De Lange, Cyrillus Ververs, Kim Roels, Jan Govaere, Filip Van Nieuwerburgh, Luc Peelman, Dieter Deforce, and Ann Van Soom. 2018. “Proteins Involved in Embryo-Maternal Interaction around the Signalling of Maternal Recognition of Pregnancy in the Horse.” SCIENTIFIC REPORTS 8. doi:10.1038/s41598-018-23537-6.
Vancouver
1.
Smits K, Willems S, Van Steendam K, Van de Velde M, De Lange V, Ververs C, et al. Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse. SCIENTIFIC REPORTS. 2018;8.
IEEE
[1]
K. Smits et al., “Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse,” SCIENTIFIC REPORTS, vol. 8, 2018.
@article{8558853,
  abstract     = {{During maternal recognition of pregnancy (MRP), a conceptus-derived signal leads to the persistence of the corpus luteum and the maintenance of gestation. In the horse, the nature of this signal remains to be elucidated. Several studies have focused on the changes in gene expression during MRP, but little information exists at the protein level. The aim of this study was to identify the proteins at the embryo-maternal interface around signalling of MRP in the horse (day 13) by means of mass spectrometry. A distinct influence of pregnancy was established, with 119 proteins differentially expressed in the uterine fluid of pregnant mares compared to cyclic mares and with upregulation of several inhibitors of the prostaglandin synthesis during pregnancy. By creating an overview of the proteins at the embryo-maternal interface in the horse, this study provides a solid foundation for further targeted studies of proteins potentially involved in embryo-maternal interactions, MRP and pregnancy loss in the horse.}},
  articleno    = {{5249}},
  author       = {{Smits, Katrien and Willems, Sander and Van Steendam, Katleen and Van de Velde, Margot and De Lange, Valérie and Ververs, Cyrillus and Roels, Kim and Govaere, Jan and Van Nieuwerburgh, Filip and Peelman, Luc and Deforce, Dieter and Van Soom, Ann}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{EQUINE ENDOMETRIUM,MASS SPECTROMETRISTS,PROGESTERONE-RECEPTOR,ESTROGEN-RECEPTOR,OXYTOCIN RECEPTOR,MARES,EXPRESSION,PROTEOMICS,PHOSPHOLIPASE-A2,PEPTIDES}},
  language     = {{eng}},
  pages        = {{14}},
  title        = {{Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse}},
  url          = {{http://doi.org/10.1038/s41598-018-23537-6}},
  volume       = {{8}},
  year         = {{2018}},
}
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