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Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse

Katrien Smits UGent, Sander Willems UGent, Katleen Van Steendam, Margot Van de Velde, Valérie De Lange, Cyrillus Ververs UGent, Kim Roels UGent, Jan Govaere UGent, Filip Van Nieuwerburgh UGent, Luc Peelman UGent, et al. (2018) SCIENTIFIC REPORTS. 8.
abstract
During maternal recognition of pregnancy (MRP), a conceptus-derived signal leads to the persistence of the corpus luteum and the maintenance of gestation. In the horse, the nature of this signal remains to be elucidated. Several studies have focused on the changes in gene expression during MRP, but little information exists at the protein level. The aim of this study was to identify the proteins at the embryo-maternal interface around signalling of MRP in the horse (day 13) by means of mass spectrometry. A distinct influence of pregnancy was established, with 119 proteins differentially expressed in the uterine fluid of pregnant mares compared to cyclic mares and with upregulation of several inhibitors of the prostaglandin synthesis during pregnancy. By creating an overview of the proteins at the embryo-maternal interface in the horse, this study provides a solid foundation for further targeted studies of proteins potentially involved in embryo-maternal interactions, MRP and pregnancy loss in the horse.
Please use this url to cite or link to this publication:
author
year
type
journalArticle (original)
publication status
published
keyword
EQUINE ENDOMETRIUM, MASS SPECTROMETRISTS, PROGESTERONE-RECEPTOR, ESTROGEN-RECEPTOR, OXYTOCIN RECEPTOR, MARES, EXPRESSION, PROTEOMICS, PHOSPHOLIPASE-A2, PEPTIDES
journal title
SCIENTIFIC REPORTS
Sci Rep
volume
8
article number
5249
pages
14 pages
publisher
Nature Publishing Group
place of publication
London
Web of Science type
Article
Web of Science id
000428367300004
ISSN
2045-2322
DOI
10.1038/s41598-018-23537-6
language
English
UGent publication?
yes
classification
U
id
8558853
handle
http://hdl.handle.net/1854/LU-8558853
date created
2018-04-12 06:39:08
date last changed
2018-05-15 09:37:09
@article{8558853,
  abstract     = {During maternal recognition of pregnancy (MRP), a conceptus-derived signal leads to the persistence of the corpus luteum and the maintenance of gestation. In the horse, the nature of this signal remains to be elucidated. Several studies have focused on the changes in gene expression during MRP, but little information exists at the protein level. The aim of this study was to identify the proteins at the embryo-maternal interface around signalling of MRP in the horse (day 13) by means of mass spectrometry. A distinct influence of pregnancy was established, with 119 proteins differentially expressed in the uterine fluid of pregnant mares compared to cyclic mares and with upregulation of several inhibitors of the prostaglandin synthesis during pregnancy. By creating an overview of the proteins at the embryo-maternal interface in the horse, this study provides a solid foundation for further targeted studies of proteins potentially involved in embryo-maternal interactions, MRP and pregnancy loss in the horse.},
  articleno    = {5249},
  author       = {Smits, Katrien and Willems, Sander and Van Steendam, Katleen and Van de Velde, Margot and De Lange, Val{\'e}rie and Ververs, Cyrillus and Roels, Kim and Govaere, Jan and Van Nieuwerburgh, Filip and Peelman, Luc and Deforce, Dieter and Van Soom, Ann},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {EQUINE ENDOMETRIUM,MASS SPECTROMETRISTS,PROGESTERONE-RECEPTOR,ESTROGEN-RECEPTOR,OXYTOCIN RECEPTOR,MARES,EXPRESSION,PROTEOMICS,PHOSPHOLIPASE-A2,PEPTIDES},
  language     = {eng},
  pages        = {14},
  publisher    = {Nature Publishing Group},
  title        = {Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse},
  url          = {http://dx.doi.org/10.1038/s41598-018-23537-6},
  volume       = {8},
  year         = {2018},
}

Chicago
Smits, Katrien, Sander Willems, Katleen Van Steendam, Margot Van de Velde, Valérie De Lange, Cyrillus Ververs, Kim Roels, et al. 2018. “Proteins Involved in Embryo-maternal Interaction Around the Signalling of Maternal Recognition of Pregnancy in the Horse.” Scientific Reports 8.
APA
Smits, Katrien, Willems, S., Van Steendam, K., Van de Velde, M., De Lange, V., Ververs, C., Roels, K., et al. (2018). Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse. SCIENTIFIC REPORTS, 8.
Vancouver
1.
Smits K, Willems S, Van Steendam K, Van de Velde M, De Lange V, Ververs C, et al. Proteins involved in embryo-maternal interaction around the signalling of maternal recognition of pregnancy in the horse. SCIENTIFIC REPORTS. London: Nature Publishing Group; 2018;8.
MLA
Smits, Katrien, Sander Willems, Katleen Van Steendam, et al. “Proteins Involved in Embryo-maternal Interaction Around the Signalling of Maternal Recognition of Pregnancy in the Horse.” SCIENTIFIC REPORTS 8 (2018): n. pag. Print.