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Two cases of seborrheic keratosis of the external ear canal : involvement of PIK3CA and FGFR3 genes

MARIE DE LOOF (UGent) , Jo Van Dorpe (UGent) , Joni Van der Meulen (UGent) , Steve Lefever (UGent) and Ingeborg Dhooge (UGent)
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Abstract
Background: Seborrheic keratosis (SK) of the outer ear canal is rarely described in literature. Etiological risk factors involved in SK such as exposure to human papillomavirus (HPV) and ultraviolet (UV) light are established but must still be confirmed. In recent years, new insights into the pathogenesis of SKs occurred in the area of molecular pathogenesis. Fibroblast growth factor receptor 3 (FGFR3) gene and p110 subunit of phosphoinositide 3-kinase (PIK3CA) oncogene mutations are known to be involved. Methods: We describe two cases of SK of the outer ear canal. We conducted a review of literature and examined the role of etiological risk factors involved in our cases. The lesions were primarily treated with surgical resection. Postoperatively, in both patients, the lesions recurred after a considerably long disease-free interval. We tested both FGFR3 and PIK3CA genes for mutations, in the primary and recurrent lesions. Results: We did not find any mutations in both genes in all samples. Conclusion: Additional research is needed to further establish possible etiological risk factors and to clarify the involvement of PIK3CA and FGFR3 genes in the pathogenesis of seborrheic keratosis of the outer ear canal. These cases underscore the need for meticulous diagnosis, treatment, and sufficient long-term follow-up.
Keywords
EPIDERMAL NEVI, MUTATIONS

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MLA
DE LOOF, MARIE, et al. “Two Cases of Seborrheic Keratosis of the External Ear Canal : Involvement of PIK3CA and FGFR3 Genes.” INTERNATIONAL JOURNAL OF DERMATOLOGY, vol. 57, no. 6, 2018, pp. 703–06, doi:10.1111/ijd.13943.
APA
DE LOOF, M., Van Dorpe, J., Van der Meulen, J., Lefever, S., & Dhooge, I. (2018). Two cases of seborrheic keratosis of the external ear canal : involvement of PIK3CA and FGFR3 genes. INTERNATIONAL JOURNAL OF DERMATOLOGY, 57(6), 703–706. https://doi.org/10.1111/ijd.13943
Chicago author-date
DE LOOF, MARIE, Jo Van Dorpe, Joni Van der Meulen, Steve Lefever, and Ingeborg Dhooge. 2018. “Two Cases of Seborrheic Keratosis of the External Ear Canal : Involvement of PIK3CA and FGFR3 Genes.” INTERNATIONAL JOURNAL OF DERMATOLOGY 57 (6): 703–6. https://doi.org/10.1111/ijd.13943.
Chicago author-date (all authors)
DE LOOF, MARIE, Jo Van Dorpe, Joni Van der Meulen, Steve Lefever, and Ingeborg Dhooge. 2018. “Two Cases of Seborrheic Keratosis of the External Ear Canal : Involvement of PIK3CA and FGFR3 Genes.” INTERNATIONAL JOURNAL OF DERMATOLOGY 57 (6): 703–706. doi:10.1111/ijd.13943.
Vancouver
1.
DE LOOF M, Van Dorpe J, Van der Meulen J, Lefever S, Dhooge I. Two cases of seborrheic keratosis of the external ear canal : involvement of PIK3CA and FGFR3 genes. INTERNATIONAL JOURNAL OF DERMATOLOGY. 2018;57(6):703–6.
IEEE
[1]
M. DE LOOF, J. Van Dorpe, J. Van der Meulen, S. Lefever, and I. Dhooge, “Two cases of seborrheic keratosis of the external ear canal : involvement of PIK3CA and FGFR3 genes,” INTERNATIONAL JOURNAL OF DERMATOLOGY, vol. 57, no. 6, pp. 703–706, 2018.
@article{8558390,
  abstract     = {{Background: Seborrheic keratosis (SK) of the outer ear canal is rarely described in literature. Etiological risk factors involved in SK such as exposure to human papillomavirus (HPV) and ultraviolet (UV) light are established but must still be confirmed. In recent years, new insights into the pathogenesis of SKs occurred in the area of molecular pathogenesis. Fibroblast growth factor receptor 3 (FGFR3) gene and p110 subunit of phosphoinositide 3-kinase (PIK3CA) oncogene mutations are known to be involved. 

Methods: We describe two cases of SK of the outer ear canal. We conducted a review of literature and examined the role of etiological risk factors involved in our cases. The lesions were primarily treated with surgical resection. Postoperatively, in both patients, the lesions recurred after a considerably long disease-free interval. We tested both FGFR3 and PIK3CA genes for mutations, in the primary and recurrent lesions.

Results: We did not find any mutations in both genes in all samples.

Conclusion: Additional research is needed to further establish possible etiological risk factors and to clarify the involvement of PIK3CA and FGFR3 genes in the pathogenesis of seborrheic keratosis of the outer ear canal. These cases underscore the need for meticulous diagnosis, treatment, and sufficient long-term follow-up.}},
  author       = {{DE LOOF, MARIE and Van Dorpe, Jo and Van der Meulen, Joni and Lefever, Steve and Dhooge, Ingeborg}},
  issn         = {{0011-9059}},
  journal      = {{INTERNATIONAL JOURNAL OF DERMATOLOGY}},
  keywords     = {{EPIDERMAL NEVI,MUTATIONS}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{703--706}},
  title        = {{Two cases of seborrheic keratosis of the external ear canal : involvement of PIK3CA and FGFR3 genes}},
  url          = {{http://doi.org/10.1111/ijd.13943}},
  volume       = {{57}},
  year         = {{2018}},
}

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