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Determinants of 1-year survival in critically ill acute leukemia patients : a GRRR-OH study

(2018) LEUKEMIA & LYMPHOMA. 59(6). p.1323-1331
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Abstract
Acute leukemia (AL) is the most common hematological malignancy requiring intensive care unit (ICU) management. Data on long-term survival are limited. This is a post hoc analysis of the prospective multicenter data from France and Belgium: A Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique [A Research Group on Acute Respiratory Failure in Onco-Hematological Patients (French)] Study, to identify determinants of 1-year survival in critically ill AL patients. A total of 278 patients were admitted in the 17 participating ICUs. Median age was 58 years and 70% had newly diagnosed leukemia. ICU mortality rate was 28.6 and 39.6% of the patients alive at 1 year. Admission for intensive monitoring was independently associated with better 1-year survival by multivariate analysis. Conversely, relapsed/refractory disease, secondary leukemia, mechanical ventilation and renal replacement therapy were independently associated with 1-year mortality. This study confirms the impact of organ dysfunction on long-term survival in ICU patients with AL. Follow-up studies to assess respiratory and renal recovery are warranted.
Keywords
Acute myeloid leukemia, acute lymphoblastic leukemia, intensive care, prognosis, ACUTE MYELOID-LEUKEMIA, INTENSIVE-CARE-UNIT, STEM-CELL TRANSPLANTATION, ACUTE LYMPHOBLASTIC-LEUKEMIA, INTERNATIONAL EXPERT PANEL, PROGNOSTIC-FACTORS, ADULT PATIENTS, HEMATOLOGICAL MALIGNANCY, MONOSOMAL KARYOTYPE, AML

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MLA
Tavares, Márcio, Virginie Lemiale, Djamel Mokart, et al. “Determinants of 1-year Survival in Critically Ill Acute Leukemia Patients : a GRRR-OH Study.” LEUKEMIA & LYMPHOMA 59.6 (2018): 1323–1331. Print.
APA
Tavares, M., Lemiale, V., Mokart, D., Pène, F., Lengliné, E., Kouatchet, A., Mayaux, J., et al. (2018). Determinants of 1-year survival in critically ill acute leukemia patients : a GRRR-OH study. LEUKEMIA & LYMPHOMA, 59(6), 1323–1331.
Chicago author-date
Tavares, Márcio, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Etienne Lengliné, Achille Kouatchet, Julien Mayaux, et al. 2018. “Determinants of 1-year Survival in Critically Ill Acute Leukemia Patients : a GRRR-OH Study.” Leukemia & Lymphoma 59 (6): 1323–1331.
Chicago author-date (all authors)
Tavares, Márcio, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Etienne Lengliné, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, and Elie Azoulay. 2018. “Determinants of 1-year Survival in Critically Ill Acute Leukemia Patients : a GRRR-OH Study.” Leukemia & Lymphoma 59 (6): 1323–1331.
Vancouver
1.
Tavares M, Lemiale V, Mokart D, Pène F, Lengliné E, Kouatchet A, et al. Determinants of 1-year survival in critically ill acute leukemia patients : a GRRR-OH study. LEUKEMIA & LYMPHOMA. 2018;59(6):1323–31.
IEEE
[1]
M. Tavares et al., “Determinants of 1-year survival in critically ill acute leukemia patients : a GRRR-OH study,” LEUKEMIA & LYMPHOMA, vol. 59, no. 6, pp. 1323–1331, 2018.
@article{8558357,
  abstract     = {Acute leukemia (AL) is the most common hematological malignancy requiring intensive care unit (ICU) management. Data on long-term survival are limited. This is a post hoc analysis of the prospective multicenter data from France and Belgium: A Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique [A Research Group on Acute Respiratory Failure in Onco-Hematological Patients (French)] Study, to identify determinants of 1-year survival in critically ill AL patients. A total of 278 patients were admitted in the 17 participating ICUs. Median age was 58 years and 70% had newly diagnosed leukemia. ICU mortality rate was 28.6 and 39.6% of the patients alive at 1 year. Admission for intensive monitoring was independently associated with better 1-year survival by multivariate analysis. Conversely, relapsed/refractory disease, secondary leukemia, mechanical ventilation and renal replacement therapy were independently associated with 1-year mortality. This study confirms the impact of organ dysfunction on long-term survival in ICU patients with AL. Follow-up studies to assess respiratory and renal recovery are warranted.},
  author       = {Tavares, Márcio and Lemiale, Virginie and Mokart, Djamel and Pène, Frédéric and Lengliné, Etienne and Kouatchet, Achille and Mayaux, Julien and Vincent, François and Nyunga, Martine and Bruneel, Fabrice and Rabbat, Antoine and Lebert, Christine and Perez, Pierre and Meert, Anne-Pascale and Benoit, Dominique and Darmon, Michael and Azoulay, Elie},
  issn         = {1042-8194},
  journal      = {LEUKEMIA & LYMPHOMA},
  keywords     = {Acute myeloid leukemia,acute lymphoblastic leukemia,intensive care,prognosis,ACUTE MYELOID-LEUKEMIA,INTENSIVE-CARE-UNIT,STEM-CELL TRANSPLANTATION,ACUTE LYMPHOBLASTIC-LEUKEMIA,INTERNATIONAL EXPERT PANEL,PROGNOSTIC-FACTORS,ADULT PATIENTS,HEMATOLOGICAL MALIGNANCY,MONOSOMAL KARYOTYPE,AML},
  language     = {eng},
  number       = {6},
  pages        = {1323--1331},
  title        = {Determinants of 1-year survival in critically ill acute leukemia patients : a GRRR-OH study},
  url          = {http://dx.doi.org/10.1080/10428194.2017.1375106},
  volume       = {59},
  year         = {2018},
}

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