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STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana

(2018) PLOS GENETICS. 14(2).
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Biotechnology for a sustainable economy (Bio-Economy)
Abstract
Organ size control is of particular importance for developmental biology and agriculture, but the mechanisms underlying organ size regulation remain elusive in plants. Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). Here we demonstrate that KIX8 and KIX9, which function as adaptors for the corepressor TOPLESS and PPD, are novel substrates of SAP. SAP interacts with KIX8/9 and modulates their protein stability. Further results show that SAP acts in a common pathway with KIX8/9 and PPD to control organ growth by regulating meristemoid cell proliferation. Thus, these findings reveal a molecular mechanism by which SAP targets the KIX-PPD repressor complex for degradation to regulate meristemoid cell proliferation and organ size.
Keywords
CELL-PROLIFERATION, STOMATAL DEVELOPMENT, LEAF MORPHOGENESIS, PLANT-GROWTH, SUBUNIT, GENE, SEED, OVEREXPRESSION, TRANSCRIPTION, COACTIVATOR

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MLA
Li, Na, Zupei Liu, Zhibiao Wang, et al. “STERILE APETALA Modulates the Stability of a Repressor Protein Complex to Control Organ Size in Arabidopsis Thaliana.” PLOS GENETICS 14.2 (2018): n. pag. Print.
APA
Li, N., Liu, Z., Wang, Z., Ru, L., Gonzalez Sanchez, N., Baekelandt, A., Pauwels, L., et al. (2018). STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana. PLOS GENETICS, 14(2).
Chicago author-date
Li, Na, Zupei Liu, Zhibiao Wang, Licong Ru, Nathalie Gonzalez Sanchez, Alexandra Baekelandt, Laurens Pauwels, et al. 2018. “STERILE APETALA Modulates the Stability of a Repressor Protein Complex to Control Organ Size in Arabidopsis Thaliana.” Plos Genetics 14 (2).
Chicago author-date (all authors)
Li, Na, Zupei Liu, Zhibiao Wang, Licong Ru, Nathalie Gonzalez Sanchez, Alexandra Baekelandt, Laurens Pauwels, Alain Goossens, Ran Xu, Zhengge Zhu, Dirk Inzé, and Yunhai Li. 2018. “STERILE APETALA Modulates the Stability of a Repressor Protein Complex to Control Organ Size in Arabidopsis Thaliana.” Plos Genetics 14 (2).
Vancouver
1.
Li N, Liu Z, Wang Z, Ru L, Gonzalez Sanchez N, Baekelandt A, et al. STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana. PLOS GENETICS. 2018;14(2).
IEEE
[1]
N. Li et al., “STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana,” PLOS GENETICS, vol. 14, no. 2, 2018.
@article{8558119,
  abstract     = {Organ size control is of particular importance for developmental biology and agriculture, but the mechanisms underlying organ size regulation remain elusive in plants. Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). Here we demonstrate that KIX8 and KIX9, which function as adaptors for the corepressor TOPLESS and PPD, are novel substrates of SAP. SAP interacts with KIX8/9 and modulates their protein stability. Further results show that SAP acts in a common pathway with KIX8/9 and PPD to control organ growth by regulating meristemoid cell proliferation. Thus, these findings reveal a molecular mechanism by which SAP targets the KIX-PPD repressor complex for degradation to regulate meristemoid cell proliferation and organ size.},
  articleno    = {e1007218},
  author       = {Li, Na and Liu, Zupei and Wang, Zhibiao and Ru, Licong and Gonzalez Sanchez, Nathalie and Baekelandt, Alexandra and Pauwels, Laurens and Goossens, Alain and Xu, Ran and Zhu, Zhengge and Inzé, Dirk and Li, Yunhai},
  issn         = {1553-7404},
  journal      = {PLOS GENETICS},
  keywords     = {CELL-PROLIFERATION,STOMATAL DEVELOPMENT,LEAF MORPHOGENESIS,PLANT-GROWTH,SUBUNIT,GENE,SEED,OVEREXPRESSION,TRANSCRIPTION,COACTIVATOR},
  language     = {eng},
  number       = {2},
  pages        = {16},
  title        = {STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana},
  url          = {http://dx.doi.org/10.1371/journal.pgen.1007218},
  volume       = {14},
  year         = {2018},
}

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