Advanced search
1 file | 563.07 KB Add to list

Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome

Author
Organization
Abstract
Objective: To review the association between orthostatic intolerance syndromes and both joint hypermobility and Ehlers-Danlos syndrome, and to propose reasons for identifying hereditary connective tissue disorders in those with orthostatic intolerance in the context of both clinical care and research. Methods: We searched the published peer-reviewed medical literature for papers reporting an association between joint hypermobility or Ehlers-Danlos syndrome and orthostatic intolerance. Results: We identified 10 relevant papers. Although methodological variability between studies introduces some limitations, the published literature consistently identifies a significantly higher prevalence of orthostatic intolerance symptoms in patients with joint hypermobility or Ehlers-Danlos syndrome than in healthy controls, and a significantly higher prevalence of cardiovascular and autonomic abnormalities both at rest and during orthostatic challenge. Postural tachycardia syndrome is the most commonly recognized circulatory disorder. The severity of orthostatic symptoms in those with EDS correlates with impairments in quality of life. Conclusion: There is a strong association between several forms of cardiovascular dysfunction, most notably postural tachycardia syndrome, and joint hypermobility or Ehlers-Danlos syndrome. We propose that recognition of joint hypermobility and Ehlers-Danlos syndrome among those with orthostatic intolerance syndromes has the potential to improve clinical care and the validity of research findings.
Keywords
Joint hypermobility, Ehlers-Danlos syndrome, Postural tachycardia syndrome, Hypotension, Syncope, neurally mediated, vasovagal, Chronic fatigue syndrome, JOINT HYPERMOBILITY SYNDROME, CHRONIC-FATIGUE-SYNDROME, QUALITY-OF-LIFE, TEMPOROMANDIBULAR DISORDERS, CONNECTIVE-TISSUE, ISOPROTERENOL, CLASSIFICATION, DIAGNOSIS, DYSAUTONOMIA, NOSOLOGY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 563.07 KB

Citation

Please use this url to cite or link to this publication:

MLA
Roma, Maria et al. “Postural Tachycardia Syndrome and Other Forms of Orthostatic Intolerance in Ehlers-Danlos Syndrome.” AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL 215 (2018): 89–96. Print.
APA
Roma, M., Marden, C. L., De Wandele, I., Francomano, C. A., & Rowe, P. C. (2018). Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 215, 89–96.
Chicago author-date
Roma, Maria, Colleen L Marden, Inge De Wandele, Clair A Francomano, and Peter C Rowe. 2018. “Postural Tachycardia Syndrome and Other Forms of Orthostatic Intolerance in Ehlers-Danlos Syndrome.” Autonomic Neuroscience-basic & Clinical 215: 89–96.
Chicago author-date (all authors)
Roma, Maria, Colleen L Marden, Inge De Wandele, Clair A Francomano, and Peter C Rowe. 2018. “Postural Tachycardia Syndrome and Other Forms of Orthostatic Intolerance in Ehlers-Danlos Syndrome.” Autonomic Neuroscience-basic & Clinical 215: 89–96.
Vancouver
1.
Roma M, Marden CL, De Wandele I, Francomano CA, Rowe PC. Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL. 2018;215:89–96.
IEEE
[1]
M. Roma, C. L. Marden, I. De Wandele, C. A. Francomano, and P. C. Rowe, “Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome,” AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, vol. 215, pp. 89–96, 2018.
@article{8558009,
  abstract     = {Objective: To review the association between orthostatic intolerance syndromes and both joint hypermobility and Ehlers-Danlos syndrome, and to propose reasons for identifying hereditary connective tissue disorders in those with orthostatic intolerance in the context of both clinical care and research. 
Methods: We searched the published peer-reviewed medical literature for papers reporting an association between joint hypermobility or Ehlers-Danlos syndrome and orthostatic intolerance. 
Results: We identified 10 relevant papers. Although methodological variability between studies introduces some limitations, the published literature consistently identifies a significantly higher prevalence of orthostatic intolerance symptoms in patients with joint hypermobility or Ehlers-Danlos syndrome than in healthy controls, and a significantly higher prevalence of cardiovascular and autonomic abnormalities both at rest and during orthostatic challenge. Postural tachycardia syndrome is the most commonly recognized circulatory disorder. The severity of orthostatic symptoms in those with EDS correlates with impairments in quality of life. 
Conclusion: There is a strong association between several forms of cardiovascular dysfunction, most notably postural tachycardia syndrome, and joint hypermobility or Ehlers-Danlos syndrome. We propose that recognition of joint hypermobility and Ehlers-Danlos syndrome among those with orthostatic intolerance syndromes has the potential to improve clinical care and the validity of research findings.},
  author       = {Roma, Maria and Marden, Colleen L and De Wandele, Inge and Francomano, Clair A and Rowe, Peter C},
  issn         = {1566-0702},
  journal      = {AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL},
  keywords     = {Joint hypermobility,Ehlers-Danlos syndrome,Postural tachycardia syndrome,Hypotension,Syncope,neurally mediated,vasovagal,Chronic fatigue syndrome,JOINT HYPERMOBILITY SYNDROME,CHRONIC-FATIGUE-SYNDROME,QUALITY-OF-LIFE,TEMPOROMANDIBULAR DISORDERS,CONNECTIVE-TISSUE,ISOPROTERENOL,CLASSIFICATION,DIAGNOSIS,DYSAUTONOMIA,NOSOLOGY},
  language     = {eng},
  pages        = {89--96},
  title        = {Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome},
  url          = {http://dx.doi.org/10.1016/j.autneu.2018.02.006},
  volume       = {215},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: