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How tyramine β-hydroxylase controls the production of octopamine, modulating the mobility of beetles

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Abstract
Biogenic amines perform many kinds of important physiological functions in the central nervous system (CNS) of insects, acting as neuromodulators, neurotransmitters, and neurohormones. The five most abundant types of biogenic amines in invertebrates are dopamine, histamine, serotonin, tyramine, and octopamine (OA). However, in beetles, an important group of model and pest insects, the role of tyramine beta-hydroxylase (T beta H) in the OA biosynthesis pathway and the regulation of behavior remains unknown so far. We therefore investigated the molecular characterization and spatiotemporal expression profiles of T beta H in red flour beetles (Triboliun castaneum). Most importantly, we detected the production of OA and measured the crawling speed of beetles after dsTcT beta H injection. We concluded that TcT beta H controls the biosynthesis amount of OA in the CNS, and this in turn modulates the mobility of the beetles. Our new results provided basic information about the key genes in the OA biosynthesis pathway of the beetles, and expanded our knowledge on the physiological functions of OA in insects.
Keywords
Tribolium castaneum, octopamine, tyramine-beta-hydroxylase, mobility: BEE APIS-MELLIFERA, RED FLOUR BEETLE, DROSOPHILA-MELANOGASTER, MANDUCA-SEXTA, EXPRESSION, IDENTIFICATION, METABOLISM, BEHAVIOR, GENE, LOCOMOTION

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Chicago
Xu, Li, Hong-Bo Jiang, Xiao-Feng Chen, Ying Xiong, Xue-Ping Lu, Yu-Xia Pei, Guy Smagghe, and Jin-Jun Wang. 2018. “How Tyramine Β-hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles.” International Journal of Molecular Sciences 19 (3).
APA
Xu, Li, Jiang, H.-B., Chen, X.-F., Xiong, Y., Lu, X.-P., Pei, Y.-X., Smagghe, G., et al. (2018). How tyramine β-hydroxylase controls the production of octopamine, modulating the mobility of beetles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(3).
Vancouver
1.
Xu L, Jiang H-B, Chen X-F, Xiong Y, Lu X-P, Pei Y-X, et al. How tyramine β-hydroxylase controls the production of octopamine, modulating the mobility of beetles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(3).
MLA
Xu, Li, Hong-Bo Jiang, Xiao-Feng Chen, et al. “How Tyramine Β-hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.3 (2018): n. pag. Print.
@article{8557726,
  abstract     = {Biogenic amines perform many kinds of important physiological functions in the central nervous system (CNS) of insects, acting as neuromodulators, neurotransmitters, and neurohormones. The five most abundant types of biogenic amines in invertebrates are dopamine, histamine, serotonin, tyramine, and octopamine (OA). However, in beetles, an important group of model and pest insects, the role of tyramine beta-hydroxylase (T beta H) in the OA biosynthesis pathway and the regulation of behavior remains unknown so far. We therefore investigated the molecular characterization and spatiotemporal expression profiles of T beta H in red flour beetles (Triboliun castaneum). Most importantly, we detected the production of OA and measured the crawling speed of beetles after dsTcT beta H injection. We concluded that TcT beta H controls the biosynthesis amount of OA in the CNS, and this in turn modulates the mobility of the beetles. Our new results provided basic information about the key genes in the OA biosynthesis pathway of the beetles, and expanded our knowledge on the physiological functions of OA in insects.},
  articleno    = {846},
  author       = {Xu, Li and Jiang, Hong-Bo and Chen, Xiao-Feng and Xiong, Ying and Lu, Xue-Ping and Pei, Yu-Xia and Smagghe, Guy and Wang, Jin-Jun},
  issn         = {1422-0067},
  journal      = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
  keyword      = {Tribolium castaneum,octopamine,tyramine-beta-hydroxylase,mobility: BEE APIS-MELLIFERA,RED FLOUR BEETLE,DROSOPHILA-MELANOGASTER,MANDUCA-SEXTA,EXPRESSION,IDENTIFICATION,METABOLISM,BEHAVIOR,GENE,LOCOMOTION},
  language     = {eng},
  number       = {3},
  pages        = {10},
  title        = {How tyramine \ensuremath{\beta}-hydroxylase controls the production of octopamine, modulating the mobility of beetles},
  url          = {http://dx.doi.org/10.3390/ijms19030846},
  volume       = {19},
  year         = {2018},
}

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