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A biomechanical analysis of shear wave elastography in pediatric heart models

Annette Caenen UGent (2018)
abstract
Early detection of cardiac disease in children is essential to optimize treatment and follow-up, but also to reduce its associated mortality and morbidity. Various cardiac imaging modalities are available for the cardiologist, mainly providing information on tissue morphology and structure with high temporal and/or spatial resolution. However, none of these imaging methods is able to directly measure stresses or intrinsic mechanical properties of the heart, which are potential key diagnostic markers to distinguish between normal and abnormal physiology. This thesis investigates the potential of a relatively new ultrasound-based technique, called shear wave elastography (SWE), to non-invasively measure myocardial stiffness. The technique generates an internal perturbation inside the tissue of interest, and consequently measures the propagation of the acoustically excited shear wave, of which the propagation speed is directly related to tissue stiffness. This allows SWE to identify regions with higher stiffness, which is associated with pathology. SWE has shown to be successful in detecting tumors in breast tissue and fibrosis in liver tissue, however application of SWE to the heart is more challenging due to the complex mechanical and structural properties of the heart. This thesis provides insights into the acoustically excited shear wave physics in the myocardium by using computer simulations in combination with experiments. Furthermore, these models also allow to assess the performance of currently used SWE-based material characterization algorithms.
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author
promoter
UGent and Abigail Swillens
organization
year
type
dissertation
publication status
published
subject
keyword
shear wave elastography, ultrasound, finite element modeling, heart, myocardial stiffness
pages
244 pages
place of publication
Gent
defense location
Gent
defense date
2018-03-19 17:00
language
English
UGent publication?
yes
classification
U
copyright statement
I have retained and own the full copyright for this publication
id
8557346
handle
http://hdl.handle.net/1854/LU-8557346
date created
2018-03-26 12:51:44
date last changed
2018-05-18 07:53:22
@phdthesis{8557346,
  abstract     = {Early detection of cardiac disease in children is essential to optimize treatment and follow-up, but also to reduce its associated mortality and morbidity. Various cardiac imaging modalities are available for the cardiologist, mainly providing information on tissue morphology and structure with high temporal and/or spatial resolution. However, none of these imaging methods is able to directly measure stresses or intrinsic mechanical properties of the heart, which are potential key diagnostic markers to distinguish between normal and abnormal physiology.
This thesis investigates the potential of a relatively new ultrasound-based technique, called shear wave elastography (SWE), to non-invasively measure myocardial stiffness. The technique generates an internal perturbation inside the tissue of interest, and consequently measures the propagation of the acoustically excited shear wave, of which the propagation speed is directly related to tissue stiffness. This allows SWE to identify regions with higher stiffness, which is associated with pathology. SWE has shown to be successful in detecting tumors in breast tissue and fibrosis in liver tissue, however application of SWE to the heart is more challenging due to the complex mechanical and structural properties of the heart. This thesis provides insights into the acoustically excited shear wave physics in the myocardium by using computer simulations in combination with experiments. Furthermore, these models also allow to assess the performance of currently used SWE-based material characterization algorithms. },
  author       = {Caenen, Annette},
  keyword      = {shear wave elastography,ultrasound,finite element modeling,heart,myocardial stiffness},
  language     = {eng},
  pages        = {244},
  school       = {Ghent University},
  title        = {A biomechanical analysis of shear wave elastography in pediatric heart models},
  year         = {2018},
}

Chicago
Caenen, Annette. 2018. “A Biomechanical Analysis of Shear Wave Elastography in Pediatric Heart Models”. Gent.
APA
Caenen, A. (2018). A biomechanical analysis of shear wave elastography in pediatric heart models. Gent.
Vancouver
1.
Caenen A. A biomechanical analysis of shear wave elastography in pediatric heart models. [Gent]; 2018.
MLA
Caenen, Annette. “A Biomechanical Analysis of Shear Wave Elastography in Pediatric Heart Models.” 2018 : n. pag. Print.