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Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet

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Abstract
Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone. Previous studies have shown that this adhesion can be ameliorated by changing the surface chemistry using plasma technology. An atmospheric pressure plasma jet is used to treat UHMWPE substrates and to modify their surface chemistry. The modifications are investigated using several surface analysis techniques. The adhesion with bone cement is assessed using pull-out tests while osteoblast adhesion and proliferation is also tested making use of several cell viability assays. Additionally, the treated samples are put in simulated body fluid and the resulting calcium phosphate (CaP) deposition is evaluated as a measure of the in vitro bioactivity of the samples. The results show that the plasma modifications result in incorporation of oxygen in the surface, which leads to a significant improved adhesion to bone cement, an enhanced osteoblast proliferation and a more pronounced CaP deposition. The plasma-treated surfaces are therefore promising to act as a shoulder implant.
Keywords
INGROWTH GLENOID COMPONENT, POLYMER SURFACES, CELL-ADHESION, FUNCTIONAL-GROUPS, THERMAL-STABILITY, POLYETHYLENE, ARTHROPLASTY, IMPROVEMENT, OXYGEN, ARGON

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Chicago
Van Vrekhem, Stijn, Karen Vloebergh, Mahtab Asadian, Christophe Vercruysse, Heidi Declercq, Alexander Van Tongel, Lieven De Wilde, Nathalie De Geyter, and Rino Morent. 2018. “Improving the Surface Properties of an UHMWPE Shoulder Implant with an Atmospheric Pressure Plasma Jet.” Scientific Reports 8.
APA
Van Vrekhem, Stijn, Vloebergh, K., Asadian, M., Vercruysse, C., Declercq, H., Van Tongel, A., De Wilde, L., et al. (2018). Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet. SCIENTIFIC REPORTS, 8.
Vancouver
1.
Van Vrekhem S, Vloebergh K, Asadian M, Vercruysse C, Declercq H, Van Tongel A, et al. Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet. SCIENTIFIC REPORTS. 2018;8.
MLA
Van Vrekhem, Stijn, Karen Vloebergh, Mahtab Asadian, et al. “Improving the Surface Properties of an UHMWPE Shoulder Implant with an Atmospheric Pressure Plasma Jet.” SCIENTIFIC REPORTS 8 (2018): n. pag. Print.
@article{8556918,
  abstract     = {Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone. Previous studies have shown that this adhesion can be ameliorated by changing the surface chemistry using plasma technology. An atmospheric pressure plasma jet is used to treat UHMWPE substrates and to modify their surface chemistry. The modifications are investigated using several surface analysis techniques. The adhesion with bone cement is assessed using pull-out tests while osteoblast adhesion and proliferation is also tested making use of several cell viability assays. Additionally, the treated samples are put in simulated body fluid and the resulting calcium phosphate (CaP) deposition is evaluated as a measure of the in vitro bioactivity of the samples. The results show that the plasma modifications result in incorporation of oxygen in the surface, which leads to a significant improved adhesion to bone cement, an enhanced osteoblast proliferation and a more pronounced CaP deposition. The plasma-treated surfaces are therefore promising to act as a shoulder implant.},
  articleno    = {4720},
  author       = {Van Vrekhem, Stijn and Vloebergh, Karen and Asadian, Mahtab and Vercruysse, Christophe and Declercq, Heidi and Van Tongel, Alexander and De Wilde, Lieven and De Geyter, Nathalie and Morent, Rino},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {INGROWTH GLENOID COMPONENT,POLYMER SURFACES,CELL-ADHESION,FUNCTIONAL-GROUPS,THERMAL-STABILITY,POLYETHYLENE,ARTHROPLASTY,IMPROVEMENT,OXYGEN,ARGON},
  language     = {eng},
  pages        = {11},
  title        = {Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet},
  url          = {http://dx.doi.org/10.1038/s41598-018-22921-6},
  volume       = {8},
  year         = {2018},
}

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