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The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model

Anouk Lanckriet UGent, Leen Timbermont UGent, Maarten De Gussem, Maja Marien, Dieter Vancraeynest, Freddy Haesebrouck UGent, Richard Ducatelle UGent and Filip Van Immerseel UGent (2010) AVIAN PATHOLOGY. 39(1). p.63-68
abstract
Necrotic enteritis poses an important health risk to broilers. The ionophore anticoccidials lasalocid, salinomycin, maduramicin, narasin and a combination of narasin and nicarbazin were tested in feed for their prophylactic effect on the incidence of necrotic enteritis in a subclinical experimental infection model that uses coccidia as a predisposing factor. In addition, drinking water medication with the antibiotics amoxicillin, tylosin and lincomycin was evaluated as curative treatment in the same experimental model. The minimal inhibitory concentrations (MICs) of all antibiotics and anticoccidials were determined in vitro against 51 Clostridium perfringens strains isolated from broilers. The strains examined appeared uniformly susceptible to lasalocid, maduramicin, narasin, salinomycin, amoxicillin and tylosin, whereas an extended frequency distribution range of MICs for lincomycin was seen, indicating acquired resistance in 36 isolates in the higher range of MICs. Nicarbazin did not inhibit the in vitro growth of the C. perfringens strains even at a concentration of 128 µg/ml. Supplementation of the diet from day 1 onwards with lasalocid, salinomycin, narasin or maduramicin led to a reduction in birds with necrotic enteritis lesions as compared with the non-medicated infected control group. A combination product of narasin and nicarbazin had no significant protective effect. Treatment with amoxicillin, lincomycin and tylosin completely stopped the development of necrotic lesions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BROILER-CHICKENS, CLOSTRIDIUM-PERFRINGENS, INTESTINAL MICROFLORA, GROWTH PROMOTERS, PERFORMANCE, FEED, SALINOMYCIN, EFFICACY, POULTRY, TYLOSIN
journal title
AVIAN PATHOLOGY
Avian Pathol.
volume
39
issue
1
pages
63 - 68
Web of Science type
Article
Web of Science id
000273794000010
JCR category
VETERINARY SCIENCES
JCR impact factor
1.967 (2010)
JCR rank
16/145 (2010)
JCR quartile
1 (2010)
ISSN
0307-9457
DOI
10.1080/03079450903505771
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
855659
handle
http://hdl.handle.net/1854/LU-855659
date created
2010-02-08 14:02:45
date last changed
2010-02-23 12:51:22
@article{855659,
  abstract     = {Necrotic enteritis poses an important health risk to broilers. The ionophore anticoccidials lasalocid, salinomycin, maduramicin, narasin and a combination of narasin and nicarbazin were tested in feed for their prophylactic effect on the incidence of necrotic enteritis in a subclinical experimental infection model that uses coccidia as a predisposing factor. In addition, drinking water medication with the antibiotics amoxicillin, tylosin and lincomycin was evaluated as curative treatment in the same experimental model. The minimal inhibitory concentrations (MICs) of all antibiotics and anticoccidials were determined in vitro against 51 Clostridium perfringens strains isolated from broilers. The strains examined appeared uniformly susceptible to lasalocid, maduramicin, narasin, salinomycin, amoxicillin and tylosin, whereas an extended frequency distribution range of MICs for lincomycin was seen, indicating acquired resistance in 36 isolates in the higher range of MICs. Nicarbazin did not inhibit the in vitro growth of the C. perfringens strains even at a concentration of 128 {\textmu}g/ml. Supplementation of the diet from day 1 onwards with lasalocid, salinomycin, narasin or maduramicin led to a reduction in birds with necrotic enteritis lesions as compared with the non-medicated infected control group. A combination product of narasin and nicarbazin had no significant protective effect. Treatment with amoxicillin, lincomycin and tylosin completely stopped the development of necrotic lesions.},
  author       = {Lanckriet, Anouk and Timbermont, Leen and De Gussem, Maarten and Marien, Maja and Vancraeynest, Dieter and Haesebrouck, Freddy and Ducatelle, Richard and Van Immerseel, Filip},
  issn         = {0307-9457},
  journal      = {AVIAN PATHOLOGY},
  keyword      = {BROILER-CHICKENS,CLOSTRIDIUM-PERFRINGENS,INTESTINAL MICROFLORA,GROWTH PROMOTERS,PERFORMANCE,FEED,SALINOMYCIN,EFFICACY,POULTRY,TYLOSIN},
  language     = {eng},
  number       = {1},
  pages        = {63--68},
  title        = {The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model},
  url          = {http://dx.doi.org/10.1080/03079450903505771},
  volume       = {39},
  year         = {2010},
}

Chicago
Lanckriet, Anouk, Leen Timbermont, Maarten De Gussem, Maja Marien, Dieter Vancraeynest, Freddy Haesebrouck, Richard Ducatelle, and Filip Van Immerseel. 2010. “The Effect of Commonly Used Anticoccidials and Antibiotics in a Subclinical Necrotic Enteritis Model.” Avian Pathology 39 (1): 63–68.
APA
Lanckriet, A., Timbermont, L., De Gussem, M., Marien, M., Vancraeynest, D., Haesebrouck, F., Ducatelle, R., et al. (2010). The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model. AVIAN PATHOLOGY, 39(1), 63–68.
Vancouver
1.
Lanckriet A, Timbermont L, De Gussem M, Marien M, Vancraeynest D, Haesebrouck F, et al. The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model. AVIAN PATHOLOGY. 2010;39(1):63–8.
MLA
Lanckriet, Anouk, Leen Timbermont, Maarten De Gussem, et al. “The Effect of Commonly Used Anticoccidials and Antibiotics in a Subclinical Necrotic Enteritis Model.” AVIAN PATHOLOGY 39.1 (2010): 63–68. Print.