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Emerging role of the unfolded protein response in tumor immunosurveillance

(2017) TRENDS IN CANCER. 3(7). p.491-505
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Abstract
Disruption of endoplasmic reticulum (ER) homeostasis results in ER stress and activation of the unfolded protein response (UPR). This response alleviates cell stress, and is activated in both tumor cells and tumor infiltrating immune cells. The UPR plays a dual function in cancer biology, acting as a barrier to tumorigenesis at the premalignant stage, while fostering cancer maintenance in established tumors. In infiltrating immune cells, the UPR has been involved in both immunosurveillance and immunosuppressive functions. This review aims to decipher the role of the UPR at different stages of tumorigenesis and how the UPR shapes the balance between immunosurveillance and immune escape. This knowledge may improve existing UPR-targeted therapies and the design of novel strategies for cancer treatment.
Keywords
cancer, immune cells, immune escape, immunosurveillance, unfolded protein response, ENDOPLASMIC-RETICULUM STRESS, CD8-ALPHA(+) DENDRITIC CELLS, BREAST-CANCER CELLS, INITIATION-FACTOR 2, PHASE-II TRIAL, ER-STRESS, TRANSCRIPTION FACTOR, ANTITUMOR IMMUNITY, MULTIPLE-MYELOMA, HEPATOCELLULAR-CARCINOMA

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Citation

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Chicago
Vanacker, Hélène, Jessica Vetters, Lyvia Moudombi, Christophe Caux, Sophie Janssens, and Marie-Cécile Michallet. 2017. “Emerging Role of the Unfolded Protein Response in Tumor Immunosurveillance.” Trends in Cancer 3 (7): 491–505.
APA
Vanacker, H., Vetters, J., Moudombi, L., Caux, C., Janssens, S., & Michallet, M.-C. (2017). Emerging role of the unfolded protein response in tumor immunosurveillance. TRENDS IN CANCER, 3(7), 491–505.
Vancouver
1.
Vanacker H, Vetters J, Moudombi L, Caux C, Janssens S, Michallet M-C. Emerging role of the unfolded protein response in tumor immunosurveillance. TRENDS IN CANCER. 2017;3(7):491–505.
MLA
Vanacker, Hélène, Jessica Vetters, Lyvia Moudombi, et al. “Emerging Role of the Unfolded Protein Response in Tumor Immunosurveillance.” TRENDS IN CANCER 3.7 (2017): 491–505. Print.
@article{8556023,
  abstract     = {Disruption of endoplasmic reticulum (ER) homeostasis results in ER stress and activation of the unfolded protein response (UPR). This response alleviates cell stress, and is activated in both tumor cells and tumor infiltrating immune cells. The UPR plays a dual function in cancer biology, acting as a barrier to tumorigenesis at the premalignant stage, while fostering cancer maintenance in established tumors. In infiltrating immune cells, the UPR has been involved in both immunosurveillance and immunosuppressive functions. This review aims to decipher the role of the UPR at different stages of tumorigenesis and how the UPR shapes the balance between immunosurveillance and immune escape. This knowledge may improve existing UPR-targeted therapies and the design of novel strategies for cancer treatment.},
  author       = {Vanacker, Hélène and Vetters, Jessica and Moudombi, Lyvia and Caux, Christophe and Janssens, Sophie and Michallet, Marie-Cécile},
  issn         = {2405-8025},
  journal      = {TRENDS IN CANCER},
  keywords     = {cancer,immune cells,immune escape,immunosurveillance,unfolded protein response,ENDOPLASMIC-RETICULUM STRESS,CD8-ALPHA(+) DENDRITIC CELLS,BREAST-CANCER CELLS,INITIATION-FACTOR 2,PHASE-II TRIAL,ER-STRESS,TRANSCRIPTION FACTOR,ANTITUMOR IMMUNITY,MULTIPLE-MYELOMA,HEPATOCELLULAR-CARCINOMA},
  language     = {eng},
  number       = {7},
  pages        = {491--505},
  title        = {Emerging role of the unfolded protein response in tumor immunosurveillance},
  url          = {http://dx.doi.org/10.1016/j.trecan.2017.05.005},
  volume       = {3},
  year         = {2017},
}

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