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High cellular monocyte activation in people living with human immunodeficiency virus on combination antiretroviral therapy and lifestyle-matched controls is associated with greater inflammation in cerebrospinal fluid

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Abstract
Background. Increased monocyte activation and intestinal damage have been shown to be predictive for the increased morbidity and mortality observed in treated people living with human immunodeficiency virus (PLHIV). Methods. A cross-sectional analysis of cellular and soluble markers of monocyte activation, coagulation, intestinal damage, and inflammation in plasma and cerebrospinal fluid (CSF) of PLHIV with suppressed plasma viremia on combination antiretroviral therapy and age and demographically comparable HIV-negative individuals participating in the Comorbidity in Relation to AIDS (COBRA) cohort and, where appropriate, age-matched blood bank donors (BBD). Results. People living with HIV, HIV-negative individuals, and BBD had comparable percentages of classical, intermediate, and nonclassical monocytes. Expression of CD163, CD32, CD64, HLA-DR, CD38, CD40, CD86, CD91, CD11c, and CX3CR1 on monocytes did not differ between PLHIV and HIV-negative individuals, but it differed significantly from BBD. Principal component analysis revealed that 57.5% of PLHIV and 62.5% of HIV-negative individuals had a high monocyte activation profile compared with 2.9% of BBD. Cellular monocyte activation in the COBRA cohort was strongly associated with soluble markers of monocyte activation and inflammation in the CSF. Conclusions. People living with HIV and HIV-negative COBRA participants had high levels of cellular monocyte activation compared with age-matched BBD. High monocyte activation was predictive for inflammation in the CSF.
Keywords
CSF, HIV, immune activation, inflammation, monocyte, HEMOGLOBIN SCAVENGER RECEPTOR, INNATE IMMUNE ACTIVATION, GUT EPITHELIAL BARRIER, CHRONIC HIV-INFECTION, CHEMOATTRACTANT PROTEIN-1, RISK-FACTORS, MARKERS, COAGULATION, DISEASE, CD163

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MLA
Booiman, Thijs, Ferdinand W Wit, Irma Maurer, et al. “High Cellular Monocyte Activation in People Living with Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-matched Controls Is Associated with Greater Inflammation in Cerebrospinal Fluid.” OPEN FORUM INFECTIOUS DISEASES 4.3 (2017): n. pag. Print.
APA
Booiman, T., Wit, F. W., Maurer, I., De Francesco, D., Sabin, C. A., Harskamp, A. M., Prins, M., et al. (2017). High cellular monocyte activation in people living with human immunodeficiency virus on combination antiretroviral therapy and lifestyle-matched controls is associated with greater inflammation in cerebrospinal fluid. OPEN FORUM INFECTIOUS DISEASES, 4(3).
Chicago author-date
Booiman, Thijs, Ferdinand W Wit, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, et al. 2017. “High Cellular Monocyte Activation in People Living with Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-matched Controls Is Associated with Greater Inflammation in Cerebrospinal Fluid.” Open Forum Infectious Diseases 4 (3).
Chicago author-date (all authors)
Booiman, Thijs, Ferdinand W Wit, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, Paolo Garagnani, Chiara Pirazzini, Claudio Franceschi, Dietmar Fuchs, Magnus Gisslén, Alan Winston, Peter Reiss, Neeltje A Kootstra, on behalf of the Comorbidity in Relation to AIDS (COBRA) Collaboration, Claude Libert, and Sylviane Dewaele. 2017. “High Cellular Monocyte Activation in People Living with Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-matched Controls Is Associated with Greater Inflammation in Cerebrospinal Fluid.” Open Forum Infectious Diseases 4 (3).
Vancouver
1.
Booiman T, Wit FW, Maurer I, De Francesco D, Sabin CA, Harskamp AM, et al. High cellular monocyte activation in people living with human immunodeficiency virus on combination antiretroviral therapy and lifestyle-matched controls is associated with greater inflammation in cerebrospinal fluid. OPEN FORUM INFECTIOUS DISEASES. 2017;4(3).
IEEE
[1]
T. Booiman et al., “High cellular monocyte activation in people living with human immunodeficiency virus on combination antiretroviral therapy and lifestyle-matched controls is associated with greater inflammation in cerebrospinal fluid,” OPEN FORUM INFECTIOUS DISEASES, vol. 4, no. 3, 2017.
@article{8555981,
  abstract     = {Background. Increased monocyte activation and intestinal damage have been shown to be predictive for the increased morbidity and mortality observed in treated people living with human immunodeficiency virus (PLHIV). 
Methods. A cross-sectional analysis of cellular and soluble markers of monocyte activation, coagulation, intestinal damage, and inflammation in plasma and cerebrospinal fluid (CSF) of PLHIV with suppressed plasma viremia on combination antiretroviral therapy and age and demographically comparable HIV-negative individuals participating in the Comorbidity in Relation to AIDS (COBRA) cohort and, where appropriate, age-matched blood bank donors (BBD). 
Results. People living with HIV, HIV-negative individuals, and BBD had comparable percentages of classical, intermediate, and nonclassical monocytes. Expression of CD163, CD32, CD64, HLA-DR, CD38, CD40, CD86, CD91, CD11c, and CX3CR1 on monocytes did not differ between PLHIV and HIV-negative individuals, but it differed significantly from BBD. Principal component analysis revealed that 57.5% of PLHIV and 62.5% of HIV-negative individuals had a high monocyte activation profile compared with 2.9% of BBD. Cellular monocyte activation in the COBRA cohort was strongly associated with soluble markers of monocyte activation and inflammation in the CSF. 
Conclusions. People living with HIV and HIV-negative COBRA participants had high levels of cellular monocyte activation compared with age-matched BBD. High monocyte activation was predictive for inflammation in the CSF.},
  articleno    = {ofx108},
  author       = {Booiman, Thijs and Wit, Ferdinand W and Maurer, Irma and De Francesco, Davide and Sabin, Caroline A and Harskamp, Agnes M and Prins, Maria and Garagnani, Paolo and Pirazzini, Chiara and Franceschi, Claudio and Fuchs, Dietmar and Gisslén, Magnus and Winston, Alan and Reiss, Peter and Kootstra, Neeltje A and Comorbidity in Relation to AIDS (COBRA) Collaboration, on behalf of the and Libert, Claude and Dewaele, Sylviane},
  issn         = {2328-8957},
  journal      = {OPEN FORUM INFECTIOUS DISEASES},
  keywords     = {CSF,HIV,immune activation,inflammation,monocyte,HEMOGLOBIN SCAVENGER RECEPTOR,INNATE IMMUNE ACTIVATION,GUT EPITHELIAL BARRIER,CHRONIC HIV-INFECTION,CHEMOATTRACTANT PROTEIN-1,RISK-FACTORS,MARKERS,COAGULATION,DISEASE,CD163},
  language     = {eng},
  number       = {3},
  pages        = {11},
  title        = {High cellular monocyte activation in people living with human immunodeficiency virus on combination antiretroviral therapy and lifestyle-matched controls is associated with greater inflammation in cerebrospinal fluid},
  url          = {http://dx.doi.org/10.1093/ofid/ofx108},
  volume       = {4},
  year         = {2017},
}

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