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EMT transcription factors in cancer development re-evaluated : beyond EMT and MET

Steven Goossens (UGent) , Niels Vandamme (UGent) , Pieter Van Vlierberghe (UGent) and Geert Berx (UGent)
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Abstract
Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20 years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.
Keywords
EPITHELIAL-MESENCHYMAL TRANSITION, TUMOR-INITIATING CELLS, STEM-CELLS, E-CADHERIN, SELF-RENEWAL, PANCREATIC-CANCER, INDUCED APOPTOSIS, DEMETHYLASE LSD1, ACTIVATOR ZEB1, IN-VIVO

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Citation

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Chicago
Goossens, Steven, Niels Vandamme, Pieter Van Vlierberghe, and Geert Berx. 2017. “EMT Transcription Factors in Cancer Development Re-evaluated : Beyond EMT and MET.” Biochimica Et Biophysica Acta-reviews on Cancer 1868 (2): 584–591.
APA
Goossens, S., Vandamme, N., Van Vlierberghe, P., & Berx, G. (2017). EMT transcription factors in cancer development re-evaluated : beyond EMT and MET. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1868(2), 584–591.
Vancouver
1.
Goossens S, Vandamme N, Van Vlierberghe P, Berx G. EMT transcription factors in cancer development re-evaluated : beyond EMT and MET. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 2017;1868(2):584–91.
MLA
Goossens, Steven, Niels Vandamme, Pieter Van Vlierberghe, et al. “EMT Transcription Factors in Cancer Development Re-evaluated : Beyond EMT and MET.” BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1868.2 (2017): 584–591. Print.
@article{8555973,
  abstract     = {Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20 years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.},
  author       = {Goossens, Steven and Vandamme, Niels and Van Vlierberghe, Pieter and Berx, Geert},
  issn         = {0304-419X},
  journal      = {BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER},
  keywords     = {EPITHELIAL-MESENCHYMAL TRANSITION,TUMOR-INITIATING CELLS,STEM-CELLS,E-CADHERIN,SELF-RENEWAL,PANCREATIC-CANCER,INDUCED APOPTOSIS,DEMETHYLASE LSD1,ACTIVATOR ZEB1,IN-VIVO},
  language     = {eng},
  number       = {2},
  pages        = {584--591},
  title        = {EMT transcription factors in cancer development re-evaluated : beyond EMT and MET},
  url          = {http://dx.doi.org/10.1016/j.bbcan.2017.06.006},
  volume       = {1868},
  year         = {2017},
}

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