@article{8555786,
  abstract     = {{Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.}},
  author       = {{Galluzzi, Lorenzo and Vitale, Ilio and Aaronson, Stuart A and Abrams, John M and Adam, Dieter and Agostinis, Patrizia and Alnemri, Emad S and Altucci, Lucia and Amelio, Ivano and Andrews, David W. and Annicchiarico-Petruzzelli, Margherita and Antonov, Alexey V. and Arama, Eli and Baehrecke, Eric H. and Barlev, Nickolai A. and Bazan, Nicolas G. and Bernassola, Francesca and Bertrand, Mathieu and Bianchi, Katiuscia and Blagosklonny, Mikhail V. and Blomgren, Klas and Borner, Christoph and Boya, Patricia and Brenner, Catherine and Campanella, Michelangelo and Candi, Eleonora and Carmona-Gutierrez, Didac and Cecconi, Francesco and Chan, Francis K. -M. and Chandel, Navdeep S. and Cheng, Emily H and Chipuk, Jerry E and Cidlowski, John A and Ciechanover, Aaron and Cohen, Gerald M and Conrad, Marcus and Cubillos-Ruiz, Juan R and Czabotar, Peter E and D'Angiolella, Vincenzo and Dawson, Ted M and Dawson, Valina L and De laurenzi, Vincenzo and De Maria, Ruggero and Debatin, Klaus-Michael and DeBerardinis, Ralph J and Deshmukh, Mohanish and Di Daniele, Nicola and Di Virgilio, Francesco and Dixit, Vishva M and Dixon, Scott J and Duckett, Colin S and Dynlacht, Brian D and El-Deiry, Wafik S and Elrod, John W and Fimia, Gian Maria and Fulda, Simone and Garcia-Saez, Ana J and Garg, Abhishek D and Garrido, Carmen and Gavathiotis, Evripidis and Golstein, Pierre and Gottlieb, Eyal and Green, Douglas R and Greene, Lloyd A and Gronemeyer, Hinrich and Gross, Atan and Hajnoczky, Gyorgy and Hardwick, J Marie and Harris, Isaac S and Hengartner, Michael O and Hetz, Claudio and Ichijo, Hidenori and Jaattela, Marja and Joseph, Bertrand and Jost, Philipp J and Juin, Philippe P and Kaiser, William J and Karin, Michael and Kaufmann, Thomas and Kepp, Oliver and Kimchi, Adi and Kitsis, Richard N and Klionsky, Daniel J and Knight, Richard A and Kumar, Sharad and Lee, Sam W and Lemasters, John J and Levine, Beth and Linkermann, Andreas and Lipton, Stuart A and Lockshin, Richard A and Lopez-Otin, Carlos and Lowe, Scott W and Luedde, Tom and Lugli, Enrico and MacFarlane, Marion and Madeo, Frank and Malewicz, Michal and Malorni, Walter and Manic, Gwenola and Marine, Jean-Christophe and Martin, Seamus J and Martinou, Jean-Claude and Medema, Jan Paul and Mehlen, Patrick and Meier, Pascal and Melino, Sonia and Miao, Edward A and Molkentin, Jeffery D and Moll, Ute M and Munoz-Pinedo, Cristina and Nagata, Shigekazu and Nunez, Gabriel and Oberst, Andrew and Oren, Moshe and Overholtzer, Michael and Pagano, Michele and Panaretakis, Theocharis and Pasparakis, Manolis and Penninger, Josef M and Pereira, David M and Pervaiz, Shazib and Peter, Marcus E and Piacentini, Mauro and Pinton, Paolo and Prehn, Jochen HM and Puthalakath, Hamsa and Rabinovich, Gabriel A and Rehm, Markus and Rizzuto, Rosario and Rodrigues, Cecilia MP and Rubinsztein, David C and Rudel, Thomas and Ryan, Kevin M and Sayan, Emre and Scorrano, Luca and Shao, Feng and Shi, Yufang and Silke, John and Simon, Hans-Uwe and Sistigu, Antonella and Stockwell, Brent R and Strasser, Andreas and Szabadkai, Gyorgy and Tait, Stephen WG and Tang, Daolin and Tavernarakis, Nektarios and Thorburn, Andrew and Tsujimoto, Yoshihide and Turk, Boris and Vanden Berghe, Tom and Vandenabeele, Peter and Vander Heiden, Matthew G and Villunger, Andreas and Virgin, Herbert W and Vousden, Karen H and Vucic, Domagoj and Wagner, Erwin F and Walczak, Henning and Wallach, David and Wang, Ying and Wells, James A and Wood, Will and Yuan, Junying and Zakeri, Zahra and Zhivotovsky, Boris and Zitvogel, Laurence and Melino, Gerry and Kroemer, Guido}},
  issn         = {{1350-9047}},
  journal      = {{CELL DEATH AND DIFFERENTIATION}},
  keywords     = {{NF-KAPPA-B,MITOCHONDRIAL PERMEABILITY TRANSITION,NEUTROPHIL,EXTRACELLULAR TRAPS,TUMOR-NECROSIS-FACTOR,BCL-2 FAMILY-MEMBER,LYSOSOMAL MEMBRANE PERMEABILIZATION,APOPTOSIS-INDUCING FACTOR,FAS-INDUCED APOPTOSIS,MIXED LINEAGE KINASE,CYTOCHROME-C RELEASE}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{486--541}},
  title        = {{Molecular mechanisms of cell death : recommendations of the Nomenclature Committee on Cell Death 2018}},
  url          = {{http://doi.org/10.1038/s41418-017-0012-4}},
  volume       = {{25}},
  year         = {{2018}},
}

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