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Microreactor technology as an efficient tool for multicomponent reactions

Ana Cukalovic UGent, Jean-Christophe Monbaliu UGent and Chris Stevens UGent (2010) Synthesis of Heterocycles via Multicomponent Reactions. In Topics in Heterocyclic Chemistry
abstract
Multicomponent reactions are an important tool in organic synthesis as they often allow the circumvention of multistep procedures by combining three or more molecules into one structure in a single step. An additional asset of the approach is the significant increase of the combinatorial possibilities, since a modification of the final product is easily accomplished by implementing minor changes in the reaction setup; this obviously allows considerable savings in time and resources. These advantages are of particular interest in pharmaceutical research for the construction of libraries. To increase the sustainability of chemical processes, the field is intensively explored, and novel reactions are frequently reported. Microreactor technology also offers a contemporary way of conducting chemical reactions in a more sustainable fashion due to the miniaturization and increased safety, and also in a technically improved manner due to intensified process efficiency. This relatively new technology is implemented in novel and improved applications and is getting more and more used in chemical research. The combination of the benefits from the two approaches clearly presents an attractive reaction design, and this chapter presents an overview of the reported examples in which the microreactor technology and the multicomponent approaches are combined, usually with dramatically improved results compared to those previously reported.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
in press
subject
keyword
Continuous flow, Heterocycles, Microreactor, Multicomponent reactions, Sustainable processes
book title
Synthesis of Heterocycles via Multicomponent Reactions
editor
Romano Orru
series title
Topics in Heterocyclic Chemistry
publisher
Springer
place of publication
Berlin, Germany
ISSN
1861-9282
language
English
UGent publication?
yes
classification
B2
id
855511
handle
http://hdl.handle.net/1854/LU-855511
date created
2010-02-08 13:10:45
date last changed
2010-02-12 15:42:42
@incollection{855511,
  abstract     = {Multicomponent reactions are an important tool in organic synthesis as they often allow the circumvention of multistep procedures by combining three or more molecules into one structure in a single step. An additional asset of the approach is the significant increase of the combinatorial possibilities, since a modification of the final product is easily accomplished by implementing minor changes in the reaction setup; this obviously allows considerable savings in time and resources. These advantages are of particular interest in pharmaceutical research for the construction of libraries. To increase the sustainability of chemical processes, the field is intensively explored, and novel reactions are frequently reported.
Microreactor technology also offers a contemporary way of conducting chemical reactions in a more sustainable fashion due to the miniaturization and increased safety, and also in a technically improved manner due to intensified process efficiency. This relatively new technology is implemented in novel and improved applications and is getting more and more used in chemical research.
The combination of the benefits from the two approaches clearly presents an attractive reaction design, and this chapter presents an overview of the reported examples in which the microreactor technology and the multicomponent approaches are combined, usually with dramatically improved results compared to those previously reported.},
  author       = {Cukalovic, Ana and Monbaliu, Jean-Christophe and Stevens, Chris},
  booktitle    = {Synthesis of Heterocycles via Multicomponent Reactions},
  editor       = {Orru, Romano},
  issn         = {1861-9282},
  keyword      = {Continuous flow,Heterocycles,Microreactor,Multicomponent reactions,Sustainable processes},
  language     = {eng},
  publisher    = {Springer},
  series       = {Topics in Heterocyclic Chemistry},
  title        = {Microreactor technology as an efficient tool for multicomponent reactions},
  year         = {2010},
}

Chicago
Cukalovic, Ana, Jean-Christophe Monbaliu, and Chris Stevens. 2010. “Microreactor Technology as an Efficient Tool for Multicomponent Reactions.” In Synthesis of Heterocycles via Multicomponent Reactions, ed. Romano Orru. Berlin, Germany: Springer.
APA
Cukalovic, A., Monbaliu, J.-C., & Stevens, C. (2010). Microreactor technology as an efficient tool for multicomponent reactions. In R. Orru (Ed.), Synthesis of Heterocycles via Multicomponent Reactions. Berlin, Germany: Springer.
Vancouver
1.
Cukalovic A, Monbaliu J-C, Stevens C. Microreactor technology as an efficient tool for multicomponent reactions. In: Orru R, editor. Synthesis of Heterocycles via Multicomponent Reactions. Berlin, Germany: Springer; 2010.
MLA
Cukalovic, Ana, Jean-Christophe Monbaliu, and Chris Stevens. “Microreactor Technology as an Efficient Tool for Multicomponent Reactions.” Synthesis of Heterocycles via Multicomponent Reactions. Ed. Romano Orru. Berlin, Germany: Springer, 2010. Print.