Advanced search
1 file | 1.25 MB Add to list
Author
Organization
Abstract
Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (A beta, A delta and C fibres) and central neurons, and affects 7-10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signalling, alterations in ion channels and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. The burden of chronic neuropathic pain seems to be related to the complexity of neuropathic symptoms, poor outcomes and difficult treatment decisions. Importantly, quality of life is impaired in patients with neuropathic pain owing to increased drug prescriptions and visits to health care providers, as well as the morbidity from the pain itself and the inciting disease. Despite challenges, progress in the understanding of the pathophysiology of neuropathic pain is spurring the development of new diagnostic procedures and personalized interventions, which emphasize the need for a multidisciplinary approach to the management of neuropathic pain.
Keywords
SPINAL-CORD STIMULATION, RANDOMIZED CONTROLLED-TRIAL, DIABETIC, PERIPHERAL NEUROPATHY, QUALITY-OF-LIFE, BACK SURGERY SYNDROME, DORSAL-ROOT GANGLION, CONVENTIONAL MEDICAL-MANAGEMENT, CORNEAL CONFOCAL, MICROSCOPY, INTRATHECAL DRUG-DELIVERY, IRRITABLE-BOWEL-SYNDROME

Downloads

  • Colloca Ludman2017 NPDR.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 1.25 MB

Citation

Please use this url to cite or link to this publication:

MLA
Colloca, Luana et al. “Neuropathic Pain.” NATURE REVIEWS DISEASE PRIMERS 3 (2017): n. pag. Print.
APA
Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A., Yarnitsky, D., Freeman, R., et al. (2017). Neuropathic pain. NATURE REVIEWS DISEASE PRIMERS, 3.
Chicago author-date
Colloca, Luana, Taylor Ludman, Didier Bouhassira, Ralf Baron, AnthonyH. Dickenson, David Yarnitsky, Roy Freeman, et al. 2017. “Neuropathic Pain.” Nature Reviews Disease Primers 3.
Chicago author-date (all authors)
Colloca, Luana, Taylor Ludman, Didier Bouhassira, Ralf Baron, AnthonyH. Dickenson, David Yarnitsky, Roy Freeman, Andrea Truini, Nadine Attal, Nanna B. Finnerup, Christopher Eccleston, Eija Kalso, David L. Bennett, RobertH. Dworkin, and Srinivasa N. Raja. 2017. “Neuropathic Pain.” Nature Reviews Disease Primers 3.
Vancouver
1.
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson A, Yarnitsky D, et al. Neuropathic pain. NATURE REVIEWS DISEASE PRIMERS. London: Nature Publishing Group; 2017;3.
IEEE
[1]
L. Colloca et al., “Neuropathic pain,” NATURE REVIEWS DISEASE PRIMERS, vol. 3, 2017.
@article{8553929,
  abstract     = {Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (A beta, A delta and C fibres) and central neurons, and affects 7-10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signalling, alterations in ion channels and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. The burden of chronic neuropathic pain seems to be related to the complexity of neuropathic symptoms, poor outcomes and difficult treatment decisions. Importantly, quality of life is impaired in patients with neuropathic pain owing to increased drug prescriptions and visits to health care providers, as well as the morbidity from the pain itself and the inciting disease. Despite challenges, progress in the understanding of the pathophysiology of neuropathic pain is spurring the development of new diagnostic procedures and personalized interventions, which emphasize the need for a multidisciplinary approach to the management of neuropathic pain.},
  articleno    = {17002},
  author       = {Colloca, Luana and Ludman, Taylor and Bouhassira, Didier and Baron, Ralf and Dickenson, AnthonyH. and Yarnitsky, David and Freeman, Roy and Truini, Andrea and Attal, Nadine and Finnerup, Nanna B. and Eccleston, Christopher and Kalso, Eija and Bennett, David L. and Dworkin, RobertH. and Raja, Srinivasa N.},
  issn         = {2056-676X},
  journal      = {NATURE REVIEWS DISEASE PRIMERS},
  keywords     = {SPINAL-CORD STIMULATION,RANDOMIZED CONTROLLED-TRIAL,DIABETIC,PERIPHERAL NEUROPATHY,QUALITY-OF-LIFE,BACK SURGERY SYNDROME,DORSAL-ROOT GANGLION,CONVENTIONAL MEDICAL-MANAGEMENT,CORNEAL CONFOCAL,MICROSCOPY,INTRATHECAL DRUG-DELIVERY,IRRITABLE-BOWEL-SYNDROME},
  language     = {eng},
  pages        = {19},
  publisher    = {Nature Publishing Group},
  title        = {Neuropathic pain},
  url          = {http://dx.doi.org/10.1038/nrdp.2017.2},
  volume       = {3},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: