Advanced search
1 file | 2.28 MB

Dynamical magnetic response of iron oxide nanoparticles inside live cells

(2018) ACS NANO. 12(3). p.2741-2752
Author
Organization
Abstract
Magnetic nanoparticles exposed to alternating magnetic fields have shown a great potential acting as magnetic hyperthermia mediators for cancer treatment. However, a dramatic and unexplained reduction of the nanoparticle magnetic heating efficiency has been evidenced when nanoparticles are located inside cells or tissues. Recent studies suggest the enhancement of nanoparticle clustering and/or immobilization after interaction with cells as possible causes, although a quantitative description of the influence of biological matrices on the magnetic response of magnetic nanoparticles under AC magnetic fields is still lacking. Here, we studied the effect of cell internalization on the dynamical magnetic response of iron oxide nanoparticles (IONPs). AC magnetometry and magnetic susceptibility measurements of two magnetic core sizes (11 and 21 tun) underscored differences in the dynamical magnetic response following cell uptake with effects more pronounced for larger sizes. Two methodologies have been employed for experimentally determining the magnetic heat losses of magnetic nanoparticles inside live cells without risking their viability as well as the suitability of magnetic nanostructures for in vitro hyperthermia studies. Our experimental results supported by theoretical calculations-reveal that the enhancement of intracellular IONP clustering mainly drives the cell internalization effects rather than intracellular IONP immobilization. Understanding the effects related to the nanoparticle transit into live cells on their magnetic response will allow the design of nanostructures containing magnetic nanoparticles whose dynamical magnetic response will remain invariable in any biological environments, allowing sustained and predictable in vivo heating efficiency.
Keywords
magnetic nanoparticles, dynamical magnetic response, magnetic interactions, magnetic hyperthermia, live cells, IN-VIVO, HEATING EFFICIENCY, HYPERTHERMIA RESPONSE, CONTRAST AGENTS, ABSORPTION RATE, LIVING CELLS, HIGH VALUES, NANOPARTICLES, VISCOSITY, NANOCUBES

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 2.28 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Cabrera, David, Annelies Coene, Jonathan Leliaert, Emilio J Artés-Ibáñez, Luc Dupré, Neil D Telling, and Francisco J Teran. 2018. “Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells.” Acs Nano 12 (3): 2741–2752.
APA
Cabrera, D., Coene, A., Leliaert, J., Artés-Ibáñez, E. J., Dupré, L., Telling, N. D., & Teran, F. J. (2018). Dynamical magnetic response of iron oxide nanoparticles inside live cells. ACS NANO, 12(3), 2741–2752.
Vancouver
1.
Cabrera D, Coene A, Leliaert J, Artés-Ibáñez EJ, Dupré L, Telling ND, et al. Dynamical magnetic response of iron oxide nanoparticles inside live cells. ACS NANO. 2018;12(3):2741–52.
MLA
Cabrera, David et al. “Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells.” ACS NANO 12.3 (2018): 2741–2752. Print.
@article{8553861,
  abstract     = {Magnetic nanoparticles exposed to alternating magnetic fields have shown a great potential acting as magnetic hyperthermia mediators for cancer treatment. However, a dramatic and unexplained reduction of the nanoparticle magnetic heating efficiency has been evidenced when nanoparticles are located inside cells or tissues. Recent studies suggest the enhancement of nanoparticle clustering and/or immobilization after interaction with cells as possible causes, although a quantitative description of the influence of biological matrices on the magnetic response of magnetic nanoparticles under AC magnetic fields is still lacking. Here, we studied the effect of cell internalization on the dynamical magnetic response of iron oxide nanoparticles (IONPs). AC magnetometry and magnetic susceptibility measurements of two magnetic core sizes (11 and 21 tun) underscored differences in the dynamical magnetic response following cell uptake with effects more pronounced for larger sizes. Two methodologies have been employed for experimentally determining the magnetic heat losses of magnetic nanoparticles inside live cells without risking their viability as well as the suitability of magnetic nanostructures for in vitro hyperthermia studies. Our experimental results supported by theoretical calculations-reveal that the enhancement of intracellular IONP clustering mainly drives the cell internalization effects rather than intracellular IONP immobilization. Understanding the effects related to the nanoparticle transit into live cells on their magnetic response will allow the design of nanostructures containing magnetic nanoparticles whose dynamical magnetic response will remain invariable in any biological environments, allowing sustained and predictable in vivo heating efficiency.},
  author       = {Cabrera, David and Coene, Annelies and Leliaert, Jonathan and Artés-Ibáñez, Emilio J and Dupré, Luc and Telling, Neil D and Teran, Francisco J},
  issn         = {1936-0851},
  journal      = {ACS NANO},
  keywords     = {magnetic nanoparticles,dynamical magnetic response,magnetic interactions,magnetic hyperthermia,live cells,IN-VIVO,HEATING EFFICIENCY,HYPERTHERMIA RESPONSE,CONTRAST AGENTS,ABSORPTION RATE,LIVING CELLS,HIGH VALUES,NANOPARTICLES,VISCOSITY,NANOCUBES},
  language     = {eng},
  number       = {3},
  pages        = {2741--2752},
  title        = {Dynamical magnetic response of iron oxide nanoparticles inside live cells},
  url          = {http://dx.doi.org/10.1021/acsnano.7b08995},
  volume       = {12},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: