
Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis
- Author
- Charly Keytsman, Laura Blancquaert, Inez Wens, Maarten Missinne, Pieter Van Noten, Frank Vandenabeele, Wim Derave (UGent) and Bert O Eijnde
- Organization
- Abstract
- BACKGROUND: Muscle carnosine is related to contractile function (Ca++ handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. METHODS: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after exercise training (EAEEX, CONEX, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAESED, CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured. RESULTS: EAE muscle carnosine levels were decreased (p < .0001) by ~ 40% to ~ 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03). CONCLUSION: Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this.
- Keywords
- Exercise Physiology and nutrition, Carnosine, Experimental autoimmune encephalomyelitis, Multiple sclerosis, Neuromuscular, Rehabilitation, muscle, BETA-ALANINE SUPPLEMENTATION, QUALITY-OF-LIFE, HIGH-INTENSITY EXERCISE, PHYSICAL-ACTIVITY, STRENGTH, FATIGUE, IMPACT, MITOCHONDRIAL, PERFORMANCE, METABOLISM
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8552302
- MLA
- Keytsman, Charly, et al. “Muscle Carnosine in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.” MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 21, 2018, pp. 24–29, doi:10.1016/j.msard.2018.02.013.
- APA
- Keytsman, C., Blancquaert, L., Wens, I., Missinne, M., Van Noten, P., Vandenabeele, F., … Eijnde, B. O. (2018). Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 21, 24–29. https://doi.org/10.1016/j.msard.2018.02.013
- Chicago author-date
- Keytsman, Charly, Laura Blancquaert, Inez Wens, Maarten Missinne, Pieter Van Noten, Frank Vandenabeele, Wim Derave, and Bert O Eijnde. 2018. “Muscle Carnosine in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.” MULTIPLE SCLEROSIS AND RELATED DISORDERS 21: 24–29. https://doi.org/10.1016/j.msard.2018.02.013.
- Chicago author-date (all authors)
- Keytsman, Charly, Laura Blancquaert, Inez Wens, Maarten Missinne, Pieter Van Noten, Frank Vandenabeele, Wim Derave, and Bert O Eijnde. 2018. “Muscle Carnosine in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.” MULTIPLE SCLEROSIS AND RELATED DISORDERS 21: 24–29. doi:10.1016/j.msard.2018.02.013.
- Vancouver
- 1.Keytsman C, Blancquaert L, Wens I, Missinne M, Van Noten P, Vandenabeele F, et al. Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis. MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2018;21:24–9.
- IEEE
- [1]C. Keytsman et al., “Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis,” MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 21, pp. 24–29, 2018.
@article{8552302, abstract = {{BACKGROUND: Muscle carnosine is related to contractile function (Ca++ handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. METHODS: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after exercise training (EAEEX, CONEX, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAESED, CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured. RESULTS: EAE muscle carnosine levels were decreased (p < .0001) by ~ 40% to ~ 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03). CONCLUSION: Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this.}}, author = {{Keytsman, Charly and Blancquaert, Laura and Wens, Inez and Missinne, Maarten and Van Noten, Pieter and Vandenabeele, Frank and Derave, Wim and Eijnde, Bert O}}, issn = {{2211-0348}}, journal = {{MULTIPLE SCLEROSIS AND RELATED DISORDERS}}, keywords = {{Exercise Physiology and nutrition,Carnosine,Experimental autoimmune encephalomyelitis,Multiple sclerosis,Neuromuscular,Rehabilitation,muscle,BETA-ALANINE SUPPLEMENTATION,QUALITY-OF-LIFE,HIGH-INTENSITY EXERCISE,PHYSICAL-ACTIVITY,STRENGTH,FATIGUE,IMPACT,MITOCHONDRIAL,PERFORMANCE,METABOLISM}}, language = {{eng}}, pages = {{24--29}}, title = {{Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis}}, url = {{http://doi.org/10.1016/j.msard.2018.02.013}}, volume = {{21}}, year = {{2018}}, }
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