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Diagnosis of multiple endocrine neoplasia type 2B and management of its ocular features

Elke Kreps (UGent) , Isabelle Van Herzeele (UGent) and Bert Callewaert (UGent)
(2018) OPHTHALMIC GENETICS. 39(2). p.268-270
Author
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Abstract
Background: To describe ocular and vascular findings in a patient with multiple endocrine neoplasia type 2B. Materials and methods: Case report of a 31-year-old male who was referred for ocular assessment following diagnosis of a carotid artery dissection and multiple vascular anomalies. Results: Clinical examination revealed a marfanoid habitus, myelinated corneal nerve fibers, neuromas in the perilimbal area, conjunctival hyperemia with peripheral corneal neovascularization, and posterior blepharitis. Diagnosis of multiple endocrine neoplasia type 2B was confirmed by genetic testing of the RET proto-oncogene. Genetic screening for hereditary aortic and peripheral vasculopathies failed to reveal an underlying cause for the vascular findings. We noted improvement of the ocular surface disease with topical corticosteroids and oral tetracyclines. Conclusions: Ophthalmologists play a vital role in recognizing this rare but lethal malignancy. We report on a patient with apart from characteristic ocular findings also staphylococcal hypersensitivity and widespread systemic vasculopathy.
Keywords
MEN type 2B, myelinated corneal nerve fibers, vasculopathy

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MLA
Kreps, Elke, Isabelle Van Herzeele, and Bert Callewaert. “Diagnosis of Multiple Endocrine Neoplasia Type 2B and Management of Its Ocular Features.” OPHTHALMIC GENETICS 39.2 (2018): 268–270. Print.
APA
Kreps, E., Van Herzeele, I., & Callewaert, B. (2018). Diagnosis of multiple endocrine neoplasia type 2B and management of its ocular features. OPHTHALMIC GENETICS, 39(2), 268–270.
Chicago author-date
Kreps, Elke, Isabelle Van Herzeele, and Bert Callewaert. 2018. “Diagnosis of Multiple Endocrine Neoplasia Type 2B and Management of Its Ocular Features.” Ophthalmic Genetics 39 (2): 268–270.
Chicago author-date (all authors)
Kreps, Elke, Isabelle Van Herzeele, and Bert Callewaert. 2018. “Diagnosis of Multiple Endocrine Neoplasia Type 2B and Management of Its Ocular Features.” Ophthalmic Genetics 39 (2): 268–270.
Vancouver
1.
Kreps E, Van Herzeele I, Callewaert B. Diagnosis of multiple endocrine neoplasia type 2B and management of its ocular features. OPHTHALMIC GENETICS. 2018;39(2):268–70.
IEEE
[1]
E. Kreps, I. Van Herzeele, and B. Callewaert, “Diagnosis of multiple endocrine neoplasia type 2B and management of its ocular features,” OPHTHALMIC GENETICS, vol. 39, no. 2, pp. 268–270, 2018.
@article{8551659,
  abstract     = {Background: To describe ocular and vascular findings in a patient with multiple endocrine neoplasia type 2B. 
Materials and methods: Case report of a 31-year-old male who was referred for ocular assessment following diagnosis of a carotid artery dissection and multiple vascular anomalies. 
Results: Clinical examination revealed a marfanoid habitus, myelinated corneal nerve fibers, neuromas in the perilimbal area, conjunctival hyperemia with peripheral corneal neovascularization, and posterior blepharitis. Diagnosis of multiple endocrine neoplasia type 2B was confirmed by genetic testing of the RET proto-oncogene. Genetic screening for hereditary aortic and peripheral vasculopathies failed to reveal an underlying cause for the vascular findings. We noted improvement of the ocular surface disease with topical corticosteroids and oral tetracyclines. 
Conclusions: Ophthalmologists play a vital role in recognizing this rare but lethal malignancy. We report on a patient with apart from characteristic ocular findings also staphylococcal hypersensitivity and widespread systemic vasculopathy.},
  author       = {Kreps, Elke and Van Herzeele, Isabelle and Callewaert, Bert},
  issn         = {1381-6810},
  journal      = {OPHTHALMIC GENETICS},
  keywords     = {MEN type 2B,myelinated corneal nerve fibers,vasculopathy},
  language     = {eng},
  number       = {2},
  pages        = {268--270},
  title        = {Diagnosis of multiple endocrine neoplasia type 2B and management of its ocular features},
  url          = {http://dx.doi.org/10.1080/13816810.2017.1408849},
  volume       = {39},
  year         = {2018},
}

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