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Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species

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Abstract
Ochratoxin A (OTA, 0.25 mg/kg body weight) was absorbed rapidly (T-max = 0.31-1.88 h) in all avian species (broiler chickens, laying hens, turkeys, and Muscovy ducks) but more slowly in broiler chickens (T-max = 1.43-4.63 h). The absolute oral bioavailability was complete in these bird species (88.0-109.6%). Ducks have a significantly higher volume of distribution (V-d) and turkeys a lower V-d compared to chickens and layers (broiler chickens, 0.27 +/- 0.12 L/kg; layers, 0.23 +/- 0.08 L/kg; turkeys, 0.18 +/- 0.04 L/kg; ducks, 0.76 +/- 0.44 L/kg). This difference in V-d can be attributed to the species-dependent differences in plasma protein binding of OTA, namely ranging between 82.2 and 88.9% in ducks and between 96.5 and 98.8% in turkeys. No significant gender differences were found in toxicokinetics or plasma protein binding.
Keywords
ochratoxin A, toxicokinetics, plasma protein binding, turkey, broiler chicken, layer, duck, birds, ENTEROHEPATIC CIRCULATION, MULTI-MYCOTOXIN, RATS, FEED, BIOTRANSFORMATION, CARCINOGENICITY, ANIMALS, PROFILE, HUMANS, FOOD

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Chicago
Devreese, Mathias, Siska Croubels, Siegrid De Baere, Ronette Gehring, and Gunther Antonissen. 2018. “Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.” Journal of Agricultural and Food Chemistry 66 (9): 2129–2135.
APA
Devreese, M., Croubels, S., De Baere, S., Gehring, R., & Antonissen, G. (2018). Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(9), 2129–2135.
Vancouver
1.
Devreese M, Croubels S, De Baere S, Gehring R, Antonissen G. Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2018;66(9):2129–35.
MLA
Devreese, Mathias, Siska Croubels, Siegrid De Baere, et al. “Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.9 (2018): 2129–2135. Print.
@article{8551273,
  abstract     = {Ochratoxin A (OTA, 0.25 mg/kg body weight) was absorbed rapidly (T-max = 0.31-1.88 h) in all avian species (broiler chickens, laying hens, turkeys, and Muscovy ducks) but more slowly in broiler chickens (T-max = 1.43-4.63 h). The absolute oral bioavailability was complete in these bird species (88.0-109.6\%). Ducks have a significantly higher volume of distribution (V-d) and turkeys a lower V-d compared to chickens and layers (broiler chickens, 0.27 +/- 0.12 L/kg; layers, 0.23 +/- 0.08 L/kg; turkeys, 0.18 +/- 0.04 L/kg; ducks, 0.76 +/- 0.44 L/kg). This difference in V-d can be attributed to the species-dependent differences in plasma protein binding of OTA, namely ranging between 82.2 and 88.9\% in ducks and between 96.5 and 98.8\% in turkeys. No significant gender differences were found in toxicokinetics or plasma protein binding.},
  author       = {Devreese, Mathias and Croubels, Siska and De Baere, Siegrid and Gehring, Ronette and Antonissen, Gunther},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  keyword      = {ochratoxin A,toxicokinetics,plasma protein binding,turkey,broiler chicken,layer,duck,birds,ENTEROHEPATIC CIRCULATION,MULTI-MYCOTOXIN,RATS,FEED,BIOTRANSFORMATION,CARCINOGENICITY,ANIMALS,PROFILE,HUMANS,FOOD},
  language     = {eng},
  number       = {9},
  pages        = {2129--2135},
  title        = {Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species},
  url          = {http://dx.doi.org/10.1021/acs.jafc.7b06048},
  volume       = {66},
  year         = {2018},
}

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