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Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species

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Abstract
Ochratoxin A (OTA, 0.25 mg/kg body weight) was absorbed rapidly (T-max = 0.31-1.88 h) in all avian species (broiler chickens, laying hens, turkeys, and Muscovy ducks) but more slowly in broiler chickens (T-max = 1.43-4.63 h). The absolute oral bioavailability was complete in these bird species (88.0-109.6%). Ducks have a significantly higher volume of distribution (V-d) and turkeys a lower V-d compared to chickens and layers (broiler chickens, 0.27 +/- 0.12 L/kg; layers, 0.23 +/- 0.08 L/kg; turkeys, 0.18 +/- 0.04 L/kg; ducks, 0.76 +/- 0.44 L/kg). This difference in V-d can be attributed to the species-dependent differences in plasma protein binding of OTA, namely ranging between 82.2 and 88.9% in ducks and between 96.5 and 98.8% in turkeys. No significant gender differences were found in toxicokinetics or plasma protein binding.
Keywords
ochratoxin A, toxicokinetics, plasma protein binding, turkey, broiler chicken, layer, duck, birds, ENTEROHEPATIC CIRCULATION, MULTI-MYCOTOXIN, RATS, FEED, BIOTRANSFORMATION, CARCINOGENICITY, ANIMALS, PROFILE, HUMANS, FOOD

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MLA
Devreese, Mathias et al. “Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.9 (2018): 2129–2135. Print.
APA
Devreese, M., Croubels, S., De Baere, S., Gehring, R., & Antonissen, G. (2018). Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(9), 2129–2135.
Chicago author-date
Devreese, Mathias, Siska Croubels, Siegrid De Baere, Ronette Gehring, and Gunther Antonissen. 2018. “Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.” Journal of Agricultural and Food Chemistry 66 (9): 2129–2135.
Chicago author-date (all authors)
Devreese, Mathias, Siska Croubels, Siegrid De Baere, Ronette Gehring, and Gunther Antonissen. 2018. “Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.” Journal of Agricultural and Food Chemistry 66 (9): 2129–2135.
Vancouver
1.
Devreese M, Croubels S, De Baere S, Gehring R, Antonissen G. Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2018;66(9):2129–35.
IEEE
[1]
M. Devreese, S. Croubels, S. De Baere, R. Gehring, and G. Antonissen, “Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species,” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 66, no. 9, pp. 2129–2135, 2018.
@article{8551273,
  abstract     = {Ochratoxin A (OTA, 0.25 mg/kg body weight) was absorbed rapidly (T-max = 0.31-1.88 h) in all avian species (broiler chickens, laying hens, turkeys, and Muscovy ducks) but more slowly in broiler chickens (T-max = 1.43-4.63 h). The absolute oral bioavailability was complete in these bird species (88.0-109.6%). Ducks have a significantly higher volume of distribution (V-d) and turkeys a lower V-d compared to chickens and layers (broiler chickens, 0.27 +/- 0.12 L/kg; layers, 0.23 +/- 0.08 L/kg; turkeys, 0.18 +/- 0.04 L/kg; ducks, 0.76 +/- 0.44 L/kg). This difference in V-d can be attributed to the species-dependent differences in plasma protein binding of OTA, namely ranging between 82.2 and 88.9% in ducks and between 96.5 and 98.8% in turkeys. No significant gender differences were found in toxicokinetics or plasma protein binding.},
  author       = {Devreese, Mathias and Croubels, Siska and De Baere, Siegrid and Gehring, Ronette and Antonissen, Gunther},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  keywords     = {ochratoxin A,toxicokinetics,plasma protein binding,turkey,broiler chicken,layer,duck,birds,ENTEROHEPATIC CIRCULATION,MULTI-MYCOTOXIN,RATS,FEED,BIOTRANSFORMATION,CARCINOGENICITY,ANIMALS,PROFILE,HUMANS,FOOD},
  language     = {eng},
  number       = {9},
  pages        = {2129--2135},
  title        = {Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species},
  url          = {http://dx.doi.org/10.1021/acs.jafc.7b06048},
  volume       = {66},
  year         = {2018},
}

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