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Langerhans cells : sensing the environment in health and disease

Julie Deckers (UGent) , Hamida Hammad (UGent) and Esther Hoste (UGent)
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Abstract
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells. It has become clear that LCs not only exert pivotal roles in immune surveillance and homeostasis but also impact on pathology by either inducing tolerance or mediating inflammation. Their unique capabilities to self-renew within the epidermis, while also being able to migrate to lymph nodes in order to present antigen, place LCs in a key position to sample the local environment and decide on the appropriate cutaneous immune response. Exciting new data distinguishing LCs from Langerin(+) dermal dendritic cells (DCs) on a functional and ontogenic level reveal crucial roles for LCs in trauma and various skin pathologies, which will be thoroughly discussed here. However, despite rapid progress in the field, the exact role of LCs during immune responses has not been completely elucidated. This review focuses on what mouse models that have been developed in order to enable the study of murine LCs and other Langerin-expressing DCs have taught us about LC development and function.
Keywords
DERMAL DENDRITIC CELLS, THYMIC STROMAL LYMPHOPOIETIN, ARYL-HYDROCARBON, RECEPTOR, ANTIGEN-PRESENTING CELLS, FC-EPSILON-RI, ALLERGIC, CONTACT-DERMATITIS, NECROSIS-FACTOR-ALPHA, REGULATORY T-CELLS, HOUSE-DUST MITE, ATOPIC-DERMATITIS, Langerhans cells, skin immunology, tumor microenvironment, atopic march, mouse models

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Citation

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Chicago
Deckers, Julie, Hamida Hammad, and Esther Hoste. 2018. “Langerhans Cells : Sensing the Environment in Health and Disease.” Frontiers in Immunology 9.
APA
Deckers, J., Hammad, H., & Hoste, E. (2018). Langerhans cells : sensing the environment in health and disease. FRONTIERS IN IMMUNOLOGY, 9.
Vancouver
1.
Deckers J, Hammad H, Hoste E. Langerhans cells : sensing the environment in health and disease. FRONTIERS IN IMMUNOLOGY. 2018;9.
MLA
Deckers, Julie, Hamida Hammad, and Esther Hoste. “Langerhans Cells : Sensing the Environment in Health and Disease.” FRONTIERS IN IMMUNOLOGY 9 (2018): n. pag. Print.
@article{8550737,
  abstract     = {In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells. It has become clear that LCs not only exert pivotal roles in immune surveillance and homeostasis but also impact on pathology by either inducing tolerance or mediating inflammation. Their unique capabilities to self-renew within the epidermis, while also being able to migrate to lymph nodes in order to present antigen, place LCs in a key position to sample the local environment and decide on the appropriate cutaneous immune response. Exciting new data distinguishing LCs from Langerin(+) dermal dendritic cells (DCs) on a functional and ontogenic level reveal crucial roles for LCs in trauma and various skin pathologies, which will be thoroughly discussed here. However, despite rapid progress in the field, the exact role of LCs during immune responses has not been completely elucidated. This review focuses on what mouse models that have been developed in order to enable the study of murine LCs and other Langerin-expressing DCs have taught us about LC development and function.},
  articleno    = {93},
  author       = {Deckers, Julie and Hammad, Hamida and Hoste, Esther},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keyword      = {DERMAL DENDRITIC CELLS,THYMIC STROMAL LYMPHOPOIETIN,ARYL-HYDROCARBON,RECEPTOR,ANTIGEN-PRESENTING CELLS,FC-EPSILON-RI,ALLERGIC,CONTACT-DERMATITIS,NECROSIS-FACTOR-ALPHA,REGULATORY T-CELLS,HOUSE-DUST MITE,ATOPIC-DERMATITIS,Langerhans cells,skin immunology,tumor microenvironment,atopic march,mouse models},
  language     = {eng},
  pages        = {14},
  title        = {Langerhans cells : sensing the environment in health and disease},
  url          = {http://dx.doi.org/10.3389/fimmu.2018.00093},
  volume       = {9},
  year         = {2018},
}

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