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STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

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Abstract
Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the beta-cell mass mainly through proliferation of preexisting and newly formed beta-cells. The molecular mechanism governing this process is still largely unknown. Given the inflammatory nature of PDL and inflammation-induced signaling via the signal transducer and activator of transcription 3 (STAT3), the activation and the role of STAT3 in PDL-induced beta-cell proliferation were investigated. Duct ligation stimulates the expression of several cytokines that can act as ligands inducing STAT3 signaling and phosphorylation in beta-cells. beta-Cell cycling increased by conditional beta-cell-specific Stat3 knockout and decreased by STAT3 activation through administration of interleukin-6. In addition, the level of DNA damage in beta-cells of PDL pancreas increased after deletion of Stat3. These data indicate a role for STAT3 in maintaining a steady state in the beta-cell, by modulating its cell cycle and protection from DNA damage.
Keywords
SIGNAL TRANSDUCER, DUCT LIGATION, KNOCKOUT MICE, UP-REGULATION, HISTONE H2AX, FACTOR-ALPHA, ACTIVATION, GROWTH, PROLIFERATION, EXPRESSION

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MLA
De Groef, S et al. “STAT3 Modulates Β-cell Cycling in Injured Mouse Pancreas and Protects Against DNA Damage.” CELL DEATH & DISEASE 7 (2016): n. pag. Print.
APA
De Groef, S, Renmans, D., Cai, Y., Leuckx, G., Roels, S., Staels, W., Gradwohl, G., et al. (2016). STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage. CELL DEATH & DISEASE, 7.
Chicago author-date
De Groef, S, D Renmans, Y Cai, G Leuckx, S Roels, Willem Staels, G Gradwohl, et al. 2016. “STAT3 Modulates Β-cell Cycling in Injured Mouse Pancreas and Protects Against DNA Damage.” Cell Death & Disease 7.
Chicago author-date (all authors)
De Groef, S, D Renmans, Y Cai, G Leuckx, S Roels, Willem Staels, G Gradwohl, L Baeyens, Y Heremans, GA Martens, N De Leu, M Sojoodi, M Van de Casteele, and H Heimberg. 2016. “STAT3 Modulates Β-cell Cycling in Injured Mouse Pancreas and Protects Against DNA Damage.” Cell Death & Disease 7.
Vancouver
1.
De Groef S, Renmans D, Cai Y, Leuckx G, Roels S, Staels W, et al. STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage. CELL DEATH & DISEASE. 2016;7.
IEEE
[1]
S. De Groef et al., “STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage,” CELL DEATH & DISEASE, vol. 7, 2016.
@article{8550089,
  abstract     = {Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the beta-cell mass mainly through proliferation of preexisting and newly formed beta-cells. The molecular mechanism governing this process is still largely unknown. Given the inflammatory nature of PDL and inflammation-induced signaling via the signal transducer and activator of transcription 3 (STAT3), the activation and the role of STAT3 in PDL-induced beta-cell proliferation were investigated. Duct ligation stimulates the expression of several cytokines that can act as ligands inducing STAT3 signaling and phosphorylation in beta-cells. beta-Cell cycling increased by conditional beta-cell-specific Stat3 knockout and decreased by STAT3 activation through administration of interleukin-6. In addition, the level of DNA damage in beta-cells of PDL pancreas increased after deletion of Stat3. These data indicate a role for STAT3 in maintaining a steady state in the beta-cell, by modulating its cell cycle and protection from DNA damage.},
  articleno    = {e2272},
  author       = {De Groef, S and Renmans, D and Cai, Y and Leuckx, G and Roels, S and Staels, Willem and Gradwohl, G and Baeyens, L and Heremans, Y and Martens, GA and De Leu, N and Sojoodi, M and Van de Casteele, M and Heimberg, H},
  issn         = {2041-4889},
  journal      = {CELL DEATH & DISEASE},
  keywords     = {SIGNAL TRANSDUCER,DUCT LIGATION,KNOCKOUT MICE,UP-REGULATION,HISTONE H2AX,FACTOR-ALPHA,ACTIVATION,GROWTH,PROLIFERATION,EXPRESSION},
  language     = {eng},
  pages        = {12},
  title        = {STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage},
  url          = {http://dx.doi.org/10.1038/cddis.2016.171},
  volume       = {7},
  year         = {2016},
}

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