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Tumor PD-L1 status and CD8+ tumor-infiltrating T cells : markers of improved prognosis in oropharyngeal cancer

Astrid De Meulenaere (UGent) , Tijl Vermassen (UGent) , SANDRINE ASPESLAGH (UGent) , Philippe Deron (UGent) , Fréderic Duprez (UGent) , Debby Laukens (UGent) , Jo Van Dorpe (UGent) , Liesbeth Ferdinande (UGent) and Sylvie Rottey (UGent)
(2017) ONCOTARGET. 8(46). p.80443-80452
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Abstract
Introduction: The aim of this study was to evaluate the expression of PD-L1 in oropharyngeal squamous cell carcinoma. Its relation with clinicopathological variables, tumor infiltrating lymphocytes and survival was also determined. Results: Positive PD-L1 status for the SP142 clone related with improved overall survival in oropharyngeal squamous cell carcinoma. Tumors heavily infiltrated by tumor infiltrating lymphocytes were also linked with better outcome, and this as well for the total number of tumor infiltrating lymphocytes as for the CD3(+) and CD8(+) T cell count. A Cox proportional hazard model proved that solely infiltrating CD8+ T cells exhibit a positive effect on overall survival (hazard ratio = 0.31 [0.14-0.70]; P = 0.0050) Materials and Methods: Formalin-fixed, paraffin-embedded tissue from oropharyngeal tumors of 99 patients was immunohistochemically stained for PD-L1 (SP142 and 22C3 clones), CD3, CD8 and FoxP3. Expression of PD-L1, CD3, CD8, FoxP3 and HPV status were correlated with clinicopathological variables. Overall survival was determined by a log-rank (Mantel-Cox) test whereas the Cox proportional hazard model was used for multivariate analysis. Conclusions: Our results demonstrate that CD8(+) T lymphocytes constitute an independent prognostic marker in patients diagnosed with oropharyngeal squamous cell carcinoma. PD-L1 positivity for SP142, but not for 22C3, also tends to have a positive effect on survival in oropharyngeal squamous cell carcinoma.
Keywords
oropharynx, HPV, PD-L1, tumor infiltrating, HUMAN-PAPILLOMAVIRUS, TONSILLAR CANCER, IMMUNE RESISTANCE, NECK-CANCER, CARCINOMA, EXPRESSION, HEAD, HPV, ASSOCIATION, ACTIVATION

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Chicago
De Meulenaere, Astrid, Tijl Vermassen, SANDRINE ASPESLAGH, Philippe Deron, Fréderic Duprez, Debby Laukens, Jo Van Dorpe, Liesbeth Ferdinande, and Sylvie Rottey. 2017. “Tumor PD-L1 Status and CD8+ Tumor-infiltrating T Cells : Markers of Improved Prognosis in Oropharyngeal Cancer.” Oncotarget 8 (46): 80443–80452.
APA
De Meulenaere, A., Vermassen, T., ASPESLAGH, S., Deron, P., Duprez, F., Laukens, D., Van Dorpe, J., et al. (2017). Tumor PD-L1 status and CD8+ tumor-infiltrating T cells : markers of improved prognosis in oropharyngeal cancer. ONCOTARGET, 8(46), 80443–80452.
Vancouver
1.
De Meulenaere A, Vermassen T, ASPESLAGH S, Deron P, Duprez F, Laukens D, et al. Tumor PD-L1 status and CD8+ tumor-infiltrating T cells : markers of improved prognosis in oropharyngeal cancer. ONCOTARGET. 2017;8(46):80443–52.
MLA
De Meulenaere, Astrid et al. “Tumor PD-L1 Status and CD8+ Tumor-infiltrating T Cells : Markers of Improved Prognosis in Oropharyngeal Cancer.” ONCOTARGET 8.46 (2017): 80443–80452. Print.
@article{8549959,
  abstract     = {Introduction: The aim of this study was to evaluate the expression of PD-L1 in oropharyngeal squamous cell carcinoma. Its relation with clinicopathological variables, tumor infiltrating lymphocytes and survival was also determined. 
Results: Positive PD-L1 status for the SP142 clone related with improved overall survival in oropharyngeal squamous cell carcinoma. Tumors heavily infiltrated by tumor infiltrating lymphocytes were also linked with better outcome, and this as well for the total number of tumor infiltrating lymphocytes as for the CD3(+) and CD8(+) T cell count. A Cox proportional hazard model proved that solely infiltrating CD8+ T cells exhibit a positive effect on overall survival (hazard ratio = 0.31 [0.14-0.70]; P = 0.0050) 
Materials and Methods: Formalin-fixed, paraffin-embedded tissue from oropharyngeal tumors of 99 patients was immunohistochemically stained for PD-L1 (SP142 and 22C3 clones), CD3, CD8 and FoxP3. Expression of PD-L1, CD3, CD8, FoxP3 and HPV status were correlated with clinicopathological variables. Overall survival was determined by a log-rank (Mantel-Cox) test whereas the Cox proportional hazard model was used for multivariate analysis. 
Conclusions: Our results demonstrate that CD8(+) T lymphocytes constitute an independent prognostic marker in patients diagnosed with oropharyngeal squamous cell carcinoma. PD-L1 positivity for SP142, but not for 22C3, also tends to have a positive effect on survival in oropharyngeal squamous cell carcinoma.},
  author       = {De Meulenaere, Astrid and Vermassen, Tijl and ASPESLAGH, SANDRINE and Deron, Philippe and Duprez, Fr{\'e}deric and Laukens, Debby and Van Dorpe, Jo and Ferdinande, Liesbeth and Rottey, Sylvie},
  issn         = {1949-2553},
  journal      = {ONCOTARGET},
  language     = {eng},
  number       = {46},
  pages        = {80443--80452},
  title        = {Tumor PD-L1 status and CD8+ tumor-infiltrating T cells : markers of improved prognosis in oropharyngeal cancer},
  url          = {http://dx.doi.org/10.18632/oncotarget.19045},
  volume       = {8},
  year         = {2017},
}

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