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A preliminary study of pulmonary vein implant applicability and safety as a potential ablation platform in a follow-up study in pigs

Tim Vandecasteele UGent, Stijn Schauvliege UGent, Matthew Philpott, Eli Clement, Gunther van Loon UGent, Lisse Vera UGent, Tim Boussy, Thomas van Bergen UGent, Wim Van Den Broeck UGent, Pieter Cornillie UGent, et al. (2018) PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY. 41(2). p.167-171
abstract
Background: Recurrence of atrial fibrillation after an ablation procedure remains a major problem which emphasizes the need for improved pulmonary vein isolation techniques. Aims: The aim of this study was to describe an implantation procedure of a pulmonary vein-stent which may possibly serve as an ablation technique in the future and to examine stent safety in a follow-up study in pigs. Methods and results: Eight pigs were catheterized and nine self-expanding nitinol stents were implanted through a transfemoral or transatrial approach into the antra of the pulmonary veins. After 3 months' follow-up, the animals were euthanized for further examination. During the follow-up phase, no complications were observed. Absence of thrombus formation or pulmonary vein wall dissection was noticed during anatomical and histological evaluation of the heart-lung packages. All implants were almost completely covered by neo-intima, of which thickness varied between 0.2 and 3.9mm. Conclusions: Stents can safely be positioned and deployed into the antra of the pulmonary veins without any acute or long-term (3 months) adverse effects. In the future, these implants could function as a permanently implanted ablation device and provide new therapeutic strategies for pulmonary vein isolation in patients with atrial fibrillation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
chronic, implantation, neo-intima, stent, swine, ATRIAL-FIBRILLATION, NEOINTIMA FORMATION, CORONARY-ARTERIES
journal title
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
PACE-Pacing Clin. Electrophysiol.
volume
41
issue
2
pages
167 - 171
Web of Science type
Article
Web of Science id
000425029100010
ISSN
0147-8389
DOI
10.1111/pace.13272
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8549934
handle
http://hdl.handle.net/1854/LU-8549934
date created
2018-02-13 13:34:10
date last changed
2018-05-09 12:23:58
@article{8549934,
  abstract     = {Background: Recurrence of atrial fibrillation after an ablation procedure remains a major problem which emphasizes the need for improved pulmonary vein isolation techniques. 
Aims: The aim of this study was to describe an implantation procedure of a pulmonary vein-stent which may possibly serve as an ablation technique in the future and to examine stent safety in a follow-up study in pigs. 
Methods and results: Eight pigs were catheterized and nine self-expanding nitinol stents were implanted through a transfemoral or transatrial approach into the antra of the pulmonary veins. After 3 months' follow-up, the animals were euthanized for further examination. During the follow-up phase, no complications were observed. Absence of thrombus formation or pulmonary vein wall dissection was noticed during anatomical and histological evaluation of the heart-lung packages. All implants were almost completely covered by neo-intima, of which thickness varied between 0.2 and 3.9mm. 
Conclusions: Stents can safely be positioned and deployed into the antra of the pulmonary veins without any acute or long-term (3 months) adverse effects. In the future, these implants could function as a permanently implanted ablation device and provide new therapeutic strategies for pulmonary vein isolation in patients with atrial fibrillation.},
  author       = {Vandecasteele, Tim and Schauvliege, Stijn and Philpott, Matthew and Clement, Eli and van Loon, Gunther and Vera, Lisse and Boussy, Tim and van Bergen, Thomas and Van Den Broeck, Wim and Cornillie, Pieter and Van Langenhove, Glenn},
  issn         = {0147-8389},
  journal      = {PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY},
  keyword      = {chronic,implantation,neo-intima,stent,swine,ATRIAL-FIBRILLATION,NEOINTIMA FORMATION,CORONARY-ARTERIES},
  language     = {eng},
  number       = {2},
  pages        = {167--171},
  title        = {A preliminary study of pulmonary vein implant applicability and safety as a potential ablation platform in a follow-up study in pigs},
  url          = {http://dx.doi.org/10.1111/pace.13272},
  volume       = {41},
  year         = {2018},
}

Chicago
Vandecasteele, Tim, Stijn Schauvliege, Matthew Philpott, Eli Clement, Gunther van Loon, Lisse Vera, Tim Boussy, et al. 2018. “A Preliminary Study of Pulmonary Vein Implant Applicability and Safety as a Potential Ablation Platform in a Follow-up Study in Pigs.” Pace-pacing and Clinical Electrophysiology 41 (2): 167–171.
APA
Vandecasteele, Tim, Schauvliege, S., Philpott, M., Clement, E., van Loon, G., Vera, L., Boussy, T., et al. (2018). A preliminary study of pulmonary vein implant applicability and safety as a potential ablation platform in a follow-up study in pigs. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 41(2), 167–171.
Vancouver
1.
Vandecasteele T, Schauvliege S, Philpott M, Clement E, van Loon G, Vera L, et al. A preliminary study of pulmonary vein implant applicability and safety as a potential ablation platform in a follow-up study in pigs. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY. 2018;41(2):167–71.
MLA
Vandecasteele, Tim, Stijn Schauvliege, Matthew Philpott, et al. “A Preliminary Study of Pulmonary Vein Implant Applicability and Safety as a Potential Ablation Platform in a Follow-up Study in Pigs.” PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 41.2 (2018): 167–171. Print.