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The transcription factor MYB29 is a regulator of ALTERNATIVE OXIDASE1a

Xinhua Zhang, Aneta Ivanova, Klaas Vandepoele UGent, Jordan Radomiljac, Jan Van de Velde, Oliver Berkowitz, Patrick Willems UGent, Yue Xu, Sophia Ng, Olivier Van Aken UGent, et al. (2017) PLANT PHYSIOLOGY. 173(3). p.1824-1843
abstract
Plants sense and integrate a variety of signals from the environment through different interacting signal transduction pathways that involve hormones and signaling molecules. Using ALTERNATIVE OXIDASE1a (AOX1a) gene expression as a model system of retrograde or stress signaling between mitochondria and the nucleus, MYB DOMAIN PROTEIN29 (MYB29) was identified as a negative regulator (regulator of alternative oxidase1a 7 [rao7] mutant) in a genetic screen of Arabidopsis (Arabidopsis thaliana). rao7/myb29 mutants have increased levels of AOX1a transcript and protein compared to wild type after induction with antimycin A. A variety of genes previously associated with the mitochondrial stress response also display enhanced transcript abundance, indicating that RAO7/MYB29 negatively regulates mitochondrial stress responses in general. Meta-analysis of hormone-responsive marker genes and identification of downstream transcription factor networks revealed that MYB29 functions in the complex interplay of ethylene, jasmonic acid, salicylic acid, and reactive oxygen species signaling by regulating the expression of various ETHYLENE RESPONSE FACTOR and WRKY transcription factors. Despite an enhanced induction of mitochondrial stress response genes, rao7/myb29 mutants displayed an increased sensitivity to combined moderate light and drought stress. These results uncover interactions between mitochondrial retrograde signaling and the regulation of glucosinolate biosynthesis, both regulated by RAO7/MYB29. This common regulator can explain why perturbation of the mitochondrial function leads to transcriptomic responses overlapping with responses to biotic stress.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ALIPHATIC GLUCOSINOLATE BIOSYNTHESIS, DIFFERENTIAL EXPRESSION ANALYSIS, MITOCHONDRIAL RETROGRADE REGULATION, GENES-ENCODING MITOCHONDRIAL, MODEL, DATA-ANALYSIS, ARABIDOPSIS-THALIANA, PSEUDOMONAS-SYRINGAE, SALICYLIC-ACID, STRESS RESPONSES, ABIOTIC STRESS
journal title
PLANT PHYSIOLOGY
Plant Physiol.
volume
173
issue
3
pages
1824 - 1843
Web of Science type
Article
Web of Science id
000400366900024
ISSN
0032-0889
1532-2548
DOI
10.1104/pp.16.01494
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to the article
copyright statement
I have transferred the copyright for this publication to the publisher
id
8549465
handle
http://hdl.handle.net/1854/LU-8549465
date created
2018-02-12 09:17:32
date last changed
2018-02-13 11:12:49
@article{8549465,
  abstract     = {Plants sense and integrate a variety of signals from the environment through different interacting signal transduction pathways that involve hormones and signaling molecules. Using ALTERNATIVE OXIDASE1a (AOX1a) gene expression as a model system of retrograde or stress signaling between mitochondria and the nucleus, MYB DOMAIN PROTEIN29 (MYB29) was identified as a negative regulator (regulator of alternative oxidase1a 7 [rao7] mutant) in a genetic screen of Arabidopsis (Arabidopsis thaliana). rao7/myb29 mutants have increased levels of AOX1a transcript and protein compared to wild type after induction with antimycin A. A variety of genes previously associated with the mitochondrial stress response also display enhanced transcript abundance, indicating that RAO7/MYB29 negatively regulates mitochondrial stress responses in general. Meta-analysis of hormone-responsive marker genes and identification of downstream transcription factor networks revealed that MYB29 functions in the complex interplay of ethylene, jasmonic acid, salicylic acid, and reactive oxygen species signaling by regulating the expression of various ETHYLENE RESPONSE FACTOR and WRKY transcription factors. Despite an enhanced induction of mitochondrial stress response genes, rao7/myb29 mutants displayed an increased sensitivity to combined moderate light and drought stress. These results uncover interactions between mitochondrial retrograde signaling and the regulation of glucosinolate biosynthesis, both regulated by RAO7/MYB29. This common regulator can explain why perturbation of the mitochondrial function leads to transcriptomic responses overlapping with responses to biotic stress.},
  author       = {Zhang, Xinhua and Ivanova, Aneta and Vandepoele, Klaas and Radomiljac, Jordan and Van de Velde, Jan and Berkowitz, Oliver and Willems, Patrick and Xu, Yue and Ng, Sophia and Van Aken, Olivier and Duncan, Owen and Zhang, Botao and Storme, Veronique and Chan, Kai Xun and Vaneechoutte, Dries and Pogson, Barry James and Van Breusegem, Frank and Whelan, James and De Clercq, Inge},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keyword      = {ALIPHATIC GLUCOSINOLATE BIOSYNTHESIS,DIFFERENTIAL EXPRESSION ANALYSIS,MITOCHONDRIAL RETROGRADE REGULATION,GENES-ENCODING MITOCHONDRIAL,MODEL,DATA-ANALYSIS,ARABIDOPSIS-THALIANA,PSEUDOMONAS-SYRINGAE,SALICYLIC-ACID,STRESS RESPONSES,ABIOTIC STRESS},
  language     = {eng},
  number       = {3},
  pages        = {1824--1843},
  title        = {The transcription factor MYB29 is a regulator of ALTERNATIVE OXIDASE1a},
  url          = {http://dx.doi.org/10.1104/pp.16.01494},
  volume       = {173},
  year         = {2017},
}

Chicago
Zhang, Xinhua, Aneta Ivanova, Klaas Vandepoele, Jordan Radomiljac, Jan Van de Velde, Oliver Berkowitz, Patrick Willems, et al. 2017. “The Transcription Factor MYB29 Is a Regulator of ALTERNATIVE OXIDASE1a.” Plant Physiology 173 (3): 1824–1843.
APA
Zhang, Xinhua, Ivanova, A., Vandepoele, K., Radomiljac, J., Van de Velde, J., Berkowitz, O., Willems, P., et al. (2017). The transcription factor MYB29 is a regulator of ALTERNATIVE OXIDASE1a. PLANT PHYSIOLOGY, 173(3), 1824–1843.
Vancouver
1.
Zhang X, Ivanova A, Vandepoele K, Radomiljac J, Van de Velde J, Berkowitz O, et al. The transcription factor MYB29 is a regulator of ALTERNATIVE OXIDASE1a. PLANT PHYSIOLOGY. 2017;173(3):1824–43.
MLA
Zhang, Xinhua, Aneta Ivanova, Klaas Vandepoele, et al. “The Transcription Factor MYB29 Is a Regulator of ALTERNATIVE OXIDASE1a.” PLANT PHYSIOLOGY 173.3 (2017): 1824–1843. Print.