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Arrhythmogenicity of fibro-fatty infiltrations

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Abstract
The onset of cardiac arrhythmias depends on electrophysiological and structural properties of cardiac tissue. One of the most important changes leading to arrhythmias is characterised by the presence of a large number of non-excitable cells in the heart, of which the most well-known example is fibrosis. Recently, adipose tissue was put forward as another similar factor contributing to cardiac arrhythmias. Adipocytes infiltrate into cardiac tissue and produce in-excitable obstacles that interfere with myocardial conduction. However, adipose infiltrates have a different spatial texture than fibrosis. Over the course of time, adipose tissue also remodels into fibrotic tissue. In this paper we investigate the arrhythmogenic mechanisms resulting from the presence of adipose tissue in the heart using computer modelling. We use the TP06 model for human ventricular cells and study how the size and percentage of adipose infiltrates affects basic properties of wave propagation and the onset of arrhythmias under high frequency pacing in a 2D model for cardiac tissue. We show that although presence of adipose infiltrates can result in the onset of cardiac arrhythmias, its impact is less than that of fibrosis. We quantify this process and discuss how the remodelling of adipose infiltrates affects arrhythmia onset.
Keywords
atrial fibrillation, biological physics, RIGHT-VENTRICULAR CARDIOMYOPATHY, ONSET ATRIAL-FIBRILLATION, ADIPOSE-TISSUE, MYOCARDIAL-INFARCTION, WAVE-PROPAGATION, DIFFUSE FIBROSIS, OBESITY, HEART, RISK, ARRHYTHMIAS

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Chicago
De Coster, Tim, Piet Claus, Ivan Kazbanov, Peter Haemers, Rik Willems, Karin R Sipido, and Alexander Panfilov. 2018. “Arrhythmogenicity of Fibro-fatty Infiltrations.” Scientific Reports 8.
APA
De Coster, Tim, Claus, P., Kazbanov, I., Haemers, P., Willems, R., Sipido, K. R., & Panfilov, A. (2018). Arrhythmogenicity of fibro-fatty infiltrations. SCIENTIFIC REPORTS, 8.
Vancouver
1.
De Coster T, Claus P, Kazbanov I, Haemers P, Willems R, Sipido KR, et al. Arrhythmogenicity of fibro-fatty infiltrations. SCIENTIFIC REPORTS. 2018;8.
MLA
De Coster, Tim, Piet Claus, Ivan Kazbanov, et al. “Arrhythmogenicity of Fibro-fatty Infiltrations.” SCIENTIFIC REPORTS 8 (2018): n. pag. Print.
@article{8548759,
  abstract     = {The onset of cardiac arrhythmias depends on electrophysiological and structural properties of cardiac tissue. One of the most important changes leading to arrhythmias is characterised by the presence of a large number of non-excitable cells in the heart, of which the most well-known example is fibrosis. Recently, adipose tissue was put forward as another similar factor contributing to cardiac arrhythmias. Adipocytes infiltrate into cardiac tissue and produce in-excitable obstacles that interfere with myocardial conduction. However, adipose infiltrates have a different spatial texture than fibrosis. Over the course of time, adipose tissue also remodels into fibrotic tissue. In this paper we investigate the arrhythmogenic mechanisms resulting from the presence of adipose tissue in the heart using computer modelling. We use the TP06 model for human ventricular cells and study how the size and percentage of adipose infiltrates affects basic properties of wave propagation and the onset of arrhythmias under high frequency pacing in a 2D model for cardiac tissue. We show that although presence of adipose infiltrates can result in the onset of cardiac arrhythmias, its impact is less than that of fibrosis. We quantify this process and discuss how the remodelling of adipose infiltrates affects arrhythmia onset.},
  articleno    = {2050},
  author       = {De Coster, Tim and Claus, Piet and Kazbanov, Ivan and Haemers, Peter and Willems, Rik and Sipido, Karin R and Panfilov, Alexander},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {atrial fibrillation,biological physics,RIGHT-VENTRICULAR CARDIOMYOPATHY,ONSET ATRIAL-FIBRILLATION,ADIPOSE-TISSUE,MYOCARDIAL-INFARCTION,WAVE-PROPAGATION,DIFFUSE FIBROSIS,OBESITY,HEART,RISK,ARRHYTHMIAS},
  language     = {eng},
  pages        = {9},
  title        = {Arrhythmogenicity of fibro-fatty infiltrations},
  url          = {http://dx.doi.org/10.1038/s41598-018-20450-w},
  volume       = {8},
  year         = {2018},
}

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