Ghent University Academic Bibliography

Advanced

The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans

Bruno Levecke UGent, Alice V Easton, Piet Cools UGent, Marco Albonico, Shaali Ame, John S Gilleard, Jennifer Keiser, Antonio Montresor, Roger Prichard, Johnny Vlaminck UGent, et al. (2018) INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. 8(1). p.67-69
abstract
The egg reduction rate (ERR) is the current standard mean to assess the efficacy of drugs against human soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura and hookworm). Although the timing of post-treatment sampling is pivotal for a readily interpretation of drug efficacy, there is lack empirical data that allows recommending the optimal time point for a follow-up egg counting. In the present study, we re-analyzed both the kinetics of worm expulsion and egg output for Ascaris lumbricoides following a single oral dose of albendazole in a series of studies previously conducted in Kenyan communities. The results indicate that it takes up to 10 days post-treatment before the expulsion of both adult male and female Ascaris worms is completed, approximately 20% of the worms being expelled between day 7 and 10 post-treatment. The sequential analysis of the egg out put, indicated a poor ERR (89.4%) at day 7 post-treatment, but a 100% ERR at day 14 and 21 post-treatment. Based on our findings we recommend to wait at least 14 days after an albendazole treatment before conducting the follow-up egg count. Any sampling before this time point may result in biased ERR estimates, due the release of residual eggs from moribund or degenerating worms.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Ascaris lumbricoides, Worm expulsion, Egg reduction rate, Anthelmintic resistance, Albendazole
journal title
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
Int. J. Parasitol.-Drugs Drug Resist.
volume
8
issue
1
pages
67 - 69
Web of Science type
Article
Web of Science id
000428405000009
ISSN
2211-3207
DOI
10.1016/j.ijpddr.2017.12.004
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8548671
handle
http://hdl.handle.net/1854/LU-8548671
date created
2018-02-09 08:10:01
date last changed
2018-06-05 13:37:10
@article{8548671,
  abstract     = {The egg reduction rate (ERR) is the current standard mean to assess the efficacy of drugs against human soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura and hookworm). Although the timing of post-treatment sampling is pivotal for a readily interpretation of drug efficacy, there is lack empirical data that allows recommending the optimal time point for a follow-up egg counting. In the present study, we re-analyzed both the kinetics of worm expulsion and egg output for Ascaris lumbricoides following a single oral dose of albendazole in a series of studies previously conducted in Kenyan communities. The results indicate that it takes up to 10 days post-treatment before the expulsion of both adult male and female Ascaris worms is completed, approximately 20\% of the worms being expelled between day 7 and 10 post-treatment. The sequential analysis of the egg out put, indicated a poor ERR (89.4\%) at day 7 post-treatment, but a 100\% ERR at day 14 and 21 post-treatment. Based on our findings we recommend to wait at least 14 days after an albendazole treatment before conducting the follow-up egg count. Any sampling before this time point may result in biased ERR estimates, due the release of residual eggs from moribund or degenerating worms.},
  author       = {Levecke, Bruno and Easton, Alice V and Cools, Piet and Albonico, Marco and Ame, Shaali and Gilleard, John S and Keiser, Jennifer and Montresor, Antonio and Prichard, Roger and Vlaminck, Johnny and Vercruysse, Jozef},
  issn         = {2211-3207},
  journal      = {INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE},
  keyword      = {Ascaris lumbricoides,Worm expulsion,Egg reduction rate,Anthelmintic resistance,Albendazole},
  language     = {eng},
  number       = {1},
  pages        = {67--69},
  title        = {The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans},
  url          = {http://dx.doi.org/10.1016/j.ijpddr.2017.12.004},
  volume       = {8},
  year         = {2018},
}

Chicago
Levecke, Bruno, Alice V Easton, Piet Cools, Marco Albonico, Shaali Ame, John S Gilleard, Jennifer Keiser, et al. 2018. “The Optimal Timing of Post-treatment Sampling for the Assessment of Anthelminthic Drug Efficacy Against Ascaris Infections in Humans.” International Journal for Parasitology-drugs and Drug Resistance 8 (1): 67–69.
APA
Levecke, B., Easton, A. V., Cools, P., Albonico, M., Ame, S., Gilleard, J. S., Keiser, J., et al. (2018). The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans. INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE, 8(1), 67–69.
Vancouver
1.
Levecke B, Easton AV, Cools P, Albonico M, Ame S, Gilleard JS, et al. The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans. INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. 2018;8(1):67–9.
MLA
Levecke, Bruno, Alice V Easton, Piet Cools, et al. “The Optimal Timing of Post-treatment Sampling for the Assessment of Anthelminthic Drug Efficacy Against Ascaris Infections in Humans.” INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE 8.1 (2018): 67–69. Print.