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Increased left prefrontal brain perfusion after MRI compatible tDCS attenuates momentary ruminative self-referential thoughts

(2017) BRAIN STIMULATION. 10(6). p.1088-1095
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Abstract
Background: Transcranial direct current stimulation (tDCS) is a non-invasive electrical stimulation technique, assumed to influence cognition and emotional processing. Objective: However, it is unclear how tDCS influences spontaneous cognitive processes such as momentary self-referential thoughts on the neuronal level. Methods: Forty healthy female volunteers participated in a single session sham-controlled crossover tDCS study while being in the MRI scanner. We measured brain perfusion (arterial spin labeling) just before and just after tDCS. Before and after the stimulation procedure, participants were scored on mood (visual analogue scales) and on the Momentary Ruminative Self-focus Inventory (MRSI). We performed a 1.5 mA, 20-min, anodal left dorsolateral prefrontal cortex, cathodal right supraorbital stimulation. Results: One sham-controlled tDCS session did not result in subjective mood changes. However, as compared to before, MRSI scores significantly decreased only after active tDCS. Regression analysis revealed that this reduction in momentary ruminative self-referential thoughts was related to tDCS-related increases in left prefrontal cortical perfusion. tDCS decreased momentary self-referential thoughts, which was associated with increasing perfusion in the left prefrontal cortex. Conclusion: Our findings are in line with the hypothesis that tDCS of the DLPFC attenuates ruminative processes. (C) 2017 Elsevier Inc. All rights reserved.
Keywords
DIRECT-CURRENT STIMULATION, FUNCTIONAL CONNECTIVITY, COGNITIVE CONTROL, FRONTAL-CORTEX, DEPRESSION, MODULATION, FMRI, MECHANISMS, NETWORKS, INSIGHTS, ASL, DLPFC, OFC, MRSI, tDCS

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Chicago
Baeken, Chris, Jonathan Remue, Marie-Anne Vanderhasselt, Andre R. Brunoni, Sara De Witte, Romain Duprat, Ernst Koster, Rudi De Raedt, and Guo-Rong Wu. 2017. “Increased Left Prefrontal Brain Perfusion After MRI Compatible tDCS Attenuates Momentary Ruminative Self-referential Thoughts.” Brain Stimulation 10 (6): 1088–1095.
APA
Baeken, C., Remue, J., Vanderhasselt, M.-A., Brunoni, A. R., De Witte, S., Duprat, R., Koster, E., et al. (2017). Increased left prefrontal brain perfusion after MRI compatible tDCS attenuates momentary ruminative self-referential thoughts. BRAIN STIMULATION, 10(6), 1088–1095.
Vancouver
1.
Baeken C, Remue J, Vanderhasselt M-A, Brunoni AR, De Witte S, Duprat R, et al. Increased left prefrontal brain perfusion after MRI compatible tDCS attenuates momentary ruminative self-referential thoughts. BRAIN STIMULATION. New york: Elsevier Science Inc; 2017;10(6):1088–95.
MLA
Baeken, Chris et al. “Increased Left Prefrontal Brain Perfusion After MRI Compatible tDCS Attenuates Momentary Ruminative Self-referential Thoughts.” BRAIN STIMULATION 10.6 (2017): 1088–1095. Print.
@article{8548479,
  abstract     = {Background: Transcranial direct current stimulation (tDCS) is a non-invasive electrical stimulation technique, assumed to influence cognition and emotional processing. Objective: However, it is unclear how tDCS influences spontaneous cognitive processes such as momentary self-referential thoughts on the neuronal level. Methods: Forty healthy female volunteers participated in a single session sham-controlled crossover tDCS study while being in the MRI scanner. We measured brain perfusion (arterial spin labeling) just before and just after tDCS. Before and after the stimulation procedure, participants were scored on mood (visual analogue scales) and on the Momentary Ruminative Self-focus Inventory (MRSI). We performed a 1.5 mA, 20-min, anodal left dorsolateral prefrontal cortex, cathodal right supraorbital stimulation. Results: One sham-controlled tDCS session did not result in subjective mood changes. However, as compared to before, MRSI scores significantly decreased only after active tDCS. Regression analysis revealed that this reduction in momentary ruminative self-referential thoughts was related to tDCS-related increases in left prefrontal cortical perfusion. tDCS decreased momentary self-referential thoughts, which was associated with increasing perfusion in the left prefrontal cortex. Conclusion: Our findings are in line with the hypothesis that tDCS of the DLPFC attenuates ruminative processes. (C) 2017 Elsevier Inc. All rights reserved.},
  author       = {Baeken, Chris and Remue, Jonathan and Vanderhasselt, Marie-Anne and Brunoni, Andre R. and De Witte, Sara and Duprat, Romain and Koster, Ernst and De Raedt, Rudi and Wu, Guo-Rong},
  issn         = {1935-861X},
  journal      = {BRAIN STIMULATION},
  language     = {eng},
  number       = {6},
  pages        = {1088--1095},
  publisher    = {Elsevier Science Inc},
  title        = {Increased left prefrontal brain perfusion after MRI compatible tDCS attenuates momentary ruminative self-referential thoughts},
  url          = {http://dx.doi.org/10.1016/j.brs.2017.09.005},
  volume       = {10},
  year         = {2017},
}

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