Advanced search
1 file | 1.51 MB

PEGylated precision segments based on sequence-defined thiolactone oligomers

Author
Organization
Abstract
A straightforward access route to multifunctional block copolymers, combining a poly(ethylene glycol) (PEG) block and a monodisperse segment with discrete monomer sequence based on thiolactone chemistry, is described. Exploiting an inverse conjugation strategy on a PEG preloaded poly(styrene) synthesis resin enables the convenient introduction of a predefined PEG-block at the alpha-terminus of thiolactone-based sequence-defined oligomers. Reaction conditions for the stepwise, submonomer synthesis at polar solid supports are optimized, using sequential synthesis on a model resin that enables to isolate and determine the purity of the oligomer segments by liquid chromatography-electrospray ionization mass spectrometry analysis. The reaction conditions are used to synthesize PEGylated 5mer precision polymers with defined monomer sequence in good yields and high purity to offer an interesting platform of macromolecules with potential for biomedical applications.
Keywords
SYNTHETIC-POLYMERS, HYBRID MATERIALS, NEXT-GENERATION, PEPTIDE, MONODISPERSE, PERFORMANCE, STRATEGIES, NANOTAPES, DESIGN, BLOCK, PEG conjugates, PEGylation, precision polymers, sequence-defined, oligomers, solid phase synthesis

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.51 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Celasun, Sensu, Filip Du Prez, and Hans G Boerner. 2017. “PEGylated Precision Segments Based on Sequence-defined Thiolactone Oligomers.” Macromolecular Rapid Communications 38 (24).
APA
Celasun, S., Du Prez, F., & Boerner, H. G. (2017). PEGylated precision segments based on sequence-defined thiolactone oligomers. MACROMOLECULAR RAPID COMMUNICATIONS, 38(24).
Vancouver
1.
Celasun S, Du Prez F, Boerner HG. PEGylated precision segments based on sequence-defined thiolactone oligomers. MACROMOLECULAR RAPID COMMUNICATIONS. 2017;38(24).
MLA
Celasun, Sensu, Filip Du Prez, and Hans G Boerner. “PEGylated Precision Segments Based on Sequence-defined Thiolactone Oligomers.” MACROMOLECULAR RAPID COMMUNICATIONS 38.24 (2017): n. pag. Print.
@article{8547577,
  abstract     = {A straightforward access route to multifunctional block copolymers, combining a poly(ethylene glycol) (PEG) block and a monodisperse segment with discrete monomer sequence based on thiolactone chemistry, is described. Exploiting an inverse conjugation strategy on a PEG preloaded poly(styrene) synthesis resin enables the convenient introduction of a predefined PEG-block at the alpha-terminus of thiolactone-based sequence-defined oligomers. Reaction conditions for the stepwise, submonomer synthesis at polar solid supports are optimized, using sequential synthesis on a model resin that enables to isolate and determine the purity of the oligomer segments by liquid chromatography-electrospray ionization mass spectrometry analysis. The reaction conditions are used to synthesize PEGylated 5mer precision polymers with defined monomer sequence in good yields and high purity to offer an interesting platform of macromolecules with potential for biomedical applications.},
  articleno    = {1700688},
  author       = {Celasun, Sensu and Du Prez, Filip and Boerner, Hans G},
  issn         = {1022-1336},
  journal      = {MACROMOLECULAR RAPID COMMUNICATIONS},
  keywords     = {SYNTHETIC-POLYMERS,HYBRID MATERIALS,NEXT-GENERATION,PEPTIDE,MONODISPERSE,PERFORMANCE,STRATEGIES,NANOTAPES,DESIGN,BLOCK,PEG conjugates,PEGylation,precision polymers,sequence-defined,oligomers,solid phase synthesis},
  language     = {eng},
  number       = {24},
  pages        = {6},
  title        = {PEGylated precision segments based on sequence-defined thiolactone oligomers},
  url          = {http://dx.doi.org/10.1002/marc.201700688},
  volume       = {38},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: