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Combining two methods of sequence definition in a convergent approach : scalable synthesis of highly defined and multifunctionalized macromolecules

(2017) CHEMISTRY-A EUROPEAN JOURNAL. 23(56). p.13906-13909
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Abstract
The straightforward convergent synthesis of sequence-defined and multifunctionalized macromolecules is described herein. The first combination of two efficient approaches for the synthesis of sequence-defined macromolecules is reported: thiolactone chemistry and the Passerini three-component reaction (P-3CR). The thiolactone moiety was used as protecting group for the thiol, allowing the synthesis of a library of sequence-defined alpha,omega-functionalized building blocks. These building blocks were subsequently efficiently coupled to oligomers with carboxylic acid functionalities in a P-3CR. Thus, larger oligomers with molecular weights of up to 4629.73 g mol(-1) were obtained in gram quantities in a convergent approach along with the introduction of independently selectable side chains (up to 15), thus clearly demonstrating the high versatility and the efficiency of the reported approach.
Keywords
ACRYLATE OLIGOMERS, BUILDING-BLOCKS, POLYMERS, INFORMATION, COPOLYMERS, convergent syntheses, multicomponent reactions, sequence control, sequence-defined macromolecules, thiolactone

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Citation

Please use this url to cite or link to this publication:

Chicago
Solleder, Susanne C, Steven Martens, Pieter Espeel, Filip Du Prez, and Michael AR Meier. 2017. “Combining Two Methods of Sequence Definition in a Convergent Approach : Scalable Synthesis of Highly Defined and Multifunctionalized Macromolecules.” Chemistry-a European Journal 23 (56): 13906–13909.
APA
Solleder, S. C., Martens, S., Espeel, P., Du Prez, F., & Meier, M. A. (2017). Combining two methods of sequence definition in a convergent approach : scalable synthesis of highly defined and multifunctionalized macromolecules. CHEMISTRY-A EUROPEAN JOURNAL, 23(56), 13906–13909.
Vancouver
1.
Solleder SC, Martens S, Espeel P, Du Prez F, Meier MA. Combining two methods of sequence definition in a convergent approach : scalable synthesis of highly defined and multifunctionalized macromolecules. CHEMISTRY-A EUROPEAN JOURNAL. 2017;23(56):13906–9.
MLA
Solleder, Susanne C, Steven Martens, Pieter Espeel, et al. “Combining Two Methods of Sequence Definition in a Convergent Approach : Scalable Synthesis of Highly Defined and Multifunctionalized Macromolecules.” CHEMISTRY-A EUROPEAN JOURNAL 23.56 (2017): 13906–13909. Print.
@article{8547559,
  abstract     = {The straightforward convergent synthesis of sequence-defined and multifunctionalized macromolecules is described herein. The first combination of two efficient approaches for the synthesis of sequence-defined macromolecules is reported: thiolactone chemistry and the Passerini three-component reaction (P-3CR). The thiolactone moiety was used as protecting group for the thiol, allowing the synthesis of a library of sequence-defined alpha,omega-functionalized building blocks. These building blocks were subsequently efficiently coupled to oligomers with carboxylic acid functionalities in a P-3CR. Thus, larger oligomers with molecular weights of up to 4629.73 g mol(-1) were obtained in gram quantities in a convergent approach along with the introduction of independently selectable side chains (up to 15), thus clearly demonstrating the high versatility and the efficiency of the reported approach.},
  author       = {Solleder, Susanne C and Martens, Steven and Espeel, Pieter and Du Prez, Filip and Meier, Michael AR},
  issn         = {0947-6539},
  journal      = {CHEMISTRY-A EUROPEAN JOURNAL},
  language     = {eng},
  number       = {56},
  pages        = {13906--13909},
  title        = {Combining two methods of sequence definition in a convergent approach : scalable synthesis of highly defined and multifunctionalized macromolecules},
  url          = {http://dx.doi.org/10.1002/chem.201703877},
  volume       = {23},
  year         = {2017},
}

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