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Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy

(2017) BRAIN. 140. p.2355-2369
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Abstract
Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures. In contrast to the canonical view that principal cell discharges dominate ictal events, the ictal sequences were predominantly composed of fast-spiking, putative inhibitory neurons, which displayed unusually strong coupling to local field potential even before seizures. The temporal evolution of activity was characterized by unique dynamics where the most correlated neuronal pairs before seizure onset displayed the largest increases in correlation strength during the seizures. These results demonstrate the selective involvement of fast spiking interneurons in structured temporal sequences during spontaneous ictal events in hippocampal and neocortical circuits in experimental models of chronic temporal lobe epilepsy.
Keywords
temporal lobe epilepsy, neuronal population activity, GABAergic cells, SINGLE-UNIT ACTIVITY, EPILEPTIFORM ACTIVITY, IN-VITRO, INHIBITORY INTERNEURONS, GABAERGIC INHIBITION, SENSORY RESPONSES, PREFRONTAL CORTEX, ENTORHINAL CORTEX, NEURAL ACTIVITY, FOCAL EPILEPSY

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MLA
Neumann, Adam R et al. “Involvement of Fast-spiking Cells in Ictal Sequences During Spontaneous Seizures in Rats with Chronic Temporal Lobe Epilepsy.” BRAIN 140 (2017): 2355–2369. Print.
APA
Neumann, A. R., Raedt, R., Steenland, H. W., Sprengers, M., Bzymek, K., Navratilova, Z., Mesina, L., et al. (2017). Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy. BRAIN, 140, 2355–2369.
Chicago author-date
Neumann, Adam R, Robrecht Raedt, Hendrik W Steenland, Mathieu Sprengers, Katarzyna Bzymek, Zaneta Navratilova, Lilia Mesina, et al. 2017. “Involvement of Fast-spiking Cells in Ictal Sequences During Spontaneous Seizures in Rats with Chronic Temporal Lobe Epilepsy.” Brain 140: 2355–2369.
Chicago author-date (all authors)
Neumann, Adam R, Robrecht Raedt, Hendrik W Steenland, Mathieu Sprengers, Katarzyna Bzymek, Zaneta Navratilova, Lilia Mesina, Jeanne Xie, Valerie Lapointe, Fabian Kloosterman, Kristl Vonck, Paul Boon, Ivan Soltesz, Bruce L McNaughton, and Artur Luczak. 2017. “Involvement of Fast-spiking Cells in Ictal Sequences During Spontaneous Seizures in Rats with Chronic Temporal Lobe Epilepsy.” Brain 140: 2355–2369.
Vancouver
1.
Neumann AR, Raedt R, Steenland HW, Sprengers M, Bzymek K, Navratilova Z, et al. Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy. BRAIN. 2017;140:2355–69.
IEEE
[1]
A. R. Neumann et al., “Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy,” BRAIN, vol. 140, pp. 2355–2369, 2017.
@article{8547299,
  abstract     = {Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures. In contrast to the canonical view that principal cell discharges dominate ictal events, the ictal sequences were predominantly composed of fast-spiking, putative inhibitory neurons, which displayed unusually strong coupling to local field potential even before seizures. The temporal evolution of activity was characterized by unique dynamics where the most correlated neuronal pairs before seizure onset displayed the largest increases in correlation strength during the seizures. These results demonstrate the selective involvement of fast spiking interneurons in structured temporal sequences during spontaneous ictal events in hippocampal and neocortical circuits in experimental models of chronic temporal lobe epilepsy.},
  author       = {Neumann, Adam R and Raedt, Robrecht and Steenland, Hendrik W and Sprengers, Mathieu and Bzymek, Katarzyna and Navratilova, Zaneta and Mesina, Lilia and Xie, Jeanne and Lapointe, Valerie and Kloosterman, Fabian and Vonck, Kristl and Boon, Paul and Soltesz, Ivan and McNaughton, Bruce L and Luczak, Artur},
  issn         = {0006-8950},
  journal      = {BRAIN},
  keywords     = {temporal lobe epilepsy,neuronal population activity,GABAergic cells,SINGLE-UNIT ACTIVITY,EPILEPTIFORM ACTIVITY,IN-VITRO,INHIBITORY INTERNEURONS,GABAERGIC INHIBITION,SENSORY RESPONSES,PREFRONTAL CORTEX,ENTORHINAL CORTEX,NEURAL ACTIVITY,FOCAL EPILEPSY},
  language     = {eng},
  pages        = {2355--2369},
  title        = {Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy},
  url          = {http://dx.doi.org/10.1093/brain/awx179},
  volume       = {140},
  year         = {2017},
}

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