@article{8547274,
  abstract     = {{Background: Adequate nutrition is necessary for the rapid brain development that occurs during infancy. 
Objectives: We tested the hypothesis that the provision of small-quantity, lipid-based nutrient supplements (SQ-LNSs) plus malaria and diarrhea treatment positively affects infant development. We also tested the effect of various doses of zinc provided in SQ-LNSs or in a tablet. 
Methods: In a partially masked, cluster-randomized controlled trial, communities in rural Burkina Faso were stratified by selected characteristics and then randomly assigned within strata to the intervention (IC; 25 communities, 2435 children) or the nonintervention (NIC; 9 communities, 785 children) cohorts. IC children were randomly assigned to 4 groups. As secondary outcomes, a subsample of 3 of these 4 groups (n = 747) and of the NIC (n = 376) were assessed for motor, language, and personal-social development at age 18 mo by using the Developmental Milestones Checklist II. The 3 IC groups received 20 g SQ-LNSs/d containing 0 or 10 mg added zinc with a placebo tablet or 20 g SQ-LNSs/d containing 0 mg added zinc with a tablet containing 5 mg Zn. All IC groups received treatment of malaria and diarrhea from age 9 to 18 mo. Data collectors and participants were aware of allocation to the IC or NIC but did not know the particular IC subgroup. 
Results: Children in the IC scored 0.34 (95% CI: 0.21, 0.46), 0.30 (95% CI: 0.15, 0.44), and 0.32 (95% CI: 0.16, 0.48) SDs higher in motor, language, and personal-social development, respectively, than did children in the NIC (All P < 0.001). Children who received different amounts of zinc did not differ significantly in any of the scores. No effect on caregiver-child interaction was found. 
Conclusion: In rural Burkina Faso, the provision of SQ-LNSs to infants from age 9 to 18 mo, regardless of added zinc content, plus malaria and diarrhea treatment positively affected motor, language, and personal-social development at age 18 mo. This trial was registered at clinicaltrials.gov as NCT00944281.}},
  author       = {{Prado, Elizabeth L and Abbeddou, Souheila and Yakes Jimenez, Elizabeth and Somé, Jérôme W and Ouédraogo, Zinewendé P and Vosti, Steve A and Dewey, Kathryn G and Brown, Kenneth H and Hess, Sonja Y and Ouédraogo, Jean-Bosco}},
  issn         = {{0022-3166}},
  journal      = {{JOURNAL OF NUTRITION}},
  keywords     = {{infant nutrition,infant development,diarrhea,malaria,language development,motor development,personal-social development,lipid-based nutrient supplements,zinc,EARLY-CHILDHOOD,MICRONUTRIENT SUPPLEMENTS,ZINC SUPPLEMENTATION,YOUNG-CHILDREN,FAMILY CARE,INTERVENTIONS,INDICATORS,MILESTONES,NUTRITION,GROWTH}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{814--822}},
  title        = {{Lipid-based nutrient supplements plus malaria and diarrhea treatment increase infant development scores in a cluster-randomized trial in Burkina Faso}},
  url          = {{http://doi.org/10.3945/jn.115.225524}},
  volume       = {{146}},
  year         = {{2016}},
}

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