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Evaluation of renal perfusion in hyperthyroid cats before and after radioiodine treatment

Emmelie Stock (UGent) , Sylvie Daminet (UGent) , Dominique Paepe (UGent) , Eva Buresova, Eva Vandermeulen (UGent) , Pascale Smets (UGent) , Luc Duchateau (UGent) , Jimmy Saunders (UGent) and Katrien Vanderperren (UGent)
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Abstract
Background: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important role in functional renal changes in hyperthyroid cats, investigation of renal perfusion may provide novel insights. Objectives: To evaluate renal perfusion in hyperthyroid cats with contrast-enhanced ultrasound (CEUS). Animals: A total of 42 hyperthyroid cats was included and evaluated before and 1 month after radioiodine treatment. Methods: Prospective intrasubject clinical trial of contrast-enhanced ultrasound using a commercial contrast agent (SonoVue) to evaluate renal perfusion. Time-intensity curves were created, and perfusion parameters were calculated by off-line software. A linear mixed model was used to examine differences between pre-and post-treatment perfusion parameters. Results: An increase in several time-related perfusion parameters was observed after radioiodine treatment, indicating a decreased blood velocity upon resolution of the hyperthyroid state. Furthermore, a small post-treatment decrease in peak enhancement was present in the renal medulla, suggesting a lower medullary blood volume. Conclusions and Clinical Importance: Contrast-enhanced ultrasound indicated a higher cortical and medullary blood velocity and higher medullary blood volume in hyperthyroid cats before radioactive treatment in comparison with 1-month post-treatment control.
Keywords
Contrast-enhanced ultrasound, Feline, Hyperthyroidism, Kidney, MICROCRYSTALLINE DEOXYCORTICOSTERONE PIVALATE, MINERALOCORTICOID SUBSTITUTION, CANINE HYPOADRENOCORTICISM, ADDISONS-DISEASE, RENIN-ACTIVITY, DOGS, ALDOSTERONE

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Chicago
Stock, Emmelie, Sylvie Daminet, Dominique Paepe, Eva Buresova, Eva Vandermeulen, Pascale Smets, Luc Duchateau, Jimmy Saunders, and Katrien Vanderperren. 2017. “Evaluation of Renal Perfusion in Hyperthyroid Cats Before and After Radioiodine Treatment.” Journal of Veterinary Internal Medicine 31 (6): 1658–1663.
APA
Stock, Emmelie, Daminet, S., Paepe, D., Buresova, E., Vandermeulen, E., Smets, P., Duchateau, L., et al. (2017). Evaluation of renal perfusion in hyperthyroid cats before and after radioiodine treatment. JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(6), 1658–1663.
Vancouver
1.
Stock E, Daminet S, Paepe D, Buresova E, Vandermeulen E, Smets P, et al. Evaluation of renal perfusion in hyperthyroid cats before and after radioiodine treatment. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2017;31(6):1658–63.
MLA
Stock, Emmelie, Sylvie Daminet, Dominique Paepe, et al. “Evaluation of Renal Perfusion in Hyperthyroid Cats Before and After Radioiodine Treatment.” JOURNAL OF VETERINARY INTERNAL MEDICINE 31.6 (2017): 1658–1663. Print.
@article{8547155,
  abstract     = {Background: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important role in functional renal changes in hyperthyroid cats, investigation of renal perfusion may provide novel insights. 
Objectives: To evaluate renal perfusion in hyperthyroid cats with contrast-enhanced ultrasound (CEUS). 
Animals: A total of 42 hyperthyroid cats was included and evaluated before and 1 month after radioiodine treatment. 
Methods: Prospective intrasubject clinical trial of contrast-enhanced ultrasound using a commercial contrast agent (SonoVue) to evaluate renal perfusion. Time-intensity curves were created, and perfusion parameters were calculated by off-line software. A linear mixed model was used to examine differences between pre-and post-treatment perfusion parameters. 
Results: An increase in several time-related perfusion parameters was observed after radioiodine treatment, indicating a decreased blood velocity upon resolution of the hyperthyroid state. Furthermore, a small post-treatment decrease in peak enhancement was present in the renal medulla, suggesting a lower medullary blood volume. 
Conclusions and Clinical Importance: Contrast-enhanced ultrasound indicated a higher cortical and medullary blood velocity and higher medullary blood volume in hyperthyroid cats before radioactive treatment in comparison with 1-month post-treatment control.},
  author       = {Stock, Emmelie and Daminet, Sylvie and Paepe, Dominique and Buresova, Eva and Vandermeulen, Eva and Smets, Pascale and Duchateau, Luc and Saunders, Jimmy and Vanderperren, Katrien},
  isbn         = {1939-1676},
  journal      = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  keyword      = {Contrast-enhanced ultrasound,Feline,Hyperthyroidism,Kidney,MICROCRYSTALLINE DEOXYCORTICOSTERONE PIVALATE,MINERALOCORTICOID SUBSTITUTION,CANINE HYPOADRENOCORTICISM,ADDISONS-DISEASE,RENIN-ACTIVITY,DOGS,ALDOSTERONE},
  language     = {eng},
  number       = {6},
  pages        = {1658--1663},
  title        = {Evaluation of renal perfusion in hyperthyroid cats before and after radioiodine treatment},
  url          = {http://dx.doi.org/10.1111/jvim.14852},
  volume       = {31},
  year         = {2017},
}

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