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Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation

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Abstract
Although high-risk (HR) human papilloma virus (HPV) infection is the primary causative factor for cervical squamous intraepithelial lesions and invasive cervical cancer, the epidemiology of potentially HR (pHR) and low-risk HPV still remains to be elucidated in HIV-infected women. In addition, the synergistic potential of the multiplicity of HPV infections harboured renders it difficult to model the impact of vaccines. This cross-sectional analysis of HIV-infected women explores the epidemiology of abnormal cytology, thereby profiling and pairing pHR/HR HPV genotypes. This cross-sectional analysis reports the findings of 593 HIV-infected women, who underwent a cytological examination and HPV genotyping. A logistic regression model was fitted to adjust for age and coinfection with pHR/HR HPV genotypes. In the 143 women with abnormal cytology, a multiple pHR/HR HPV genotype prevalence of 64.1% [95% confidence interval (CI): 44.6-57.6%] was observed. A combined prevalence of HPV 16 and HPV 18 of 29.6% (95% CI: 22.2-37.8%) was found. HPV 6 and HPV 66 were found in two cases of low-grade squamous intraepithelial lesions as stand-alone genotypes and HPV 53 in a high-grade squamous intraepithelial lesion case. Pairing involving HPV 31 with HPV 16 and HPV 58 was found in high-grade squamous intraepithelial lesion cases. Significant associations were observed between abnormal cytology, multiple HPV, HPV 39 and HPV 53 [adjusted odds ratio (aOR): 2.02; P=0.01; 95% CI: 1.2-3.5; aOR: 3.8; P=0.01; 95% CI: 1.4-10.7; and aOR: 0.5; P=0.03; 95% CI: 0.2-0.9, respectively]. Coinfection with pHR/HR HPV genotypes HPV 39 and 53 was significantly associated with abnormal cytology. Research into the imputed role of HPV 31 in pairings, low-risk and pHR HPV genotypes in HIV-infected women is warranted.
Keywords
HUMAN-IMMUNODEFICIENCY-VIRUS, SQUAMOUS INTRAEPITHELIAL LESIONS, RIO-DE-JANEIRO, CERVICAL-CANCER, HIGH PREVALENCE, POSITIVE WOMEN, HPV, GENOTYPES, RISK-FACTORS, GUIDELINES, CYTOLOGY, high-risk human papilloma virus, HIV, low-risk human papilloma virus, multiple potential high-risk, high-risk coinfections, potential, high-risk human papilloma virus, vaccine efficacy

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MLA
Menon, Sonia, et al. “Human Papilloma Virus Infection in HIV-Infected Women in Belgium : Implications for Prophylactic Vaccines within This Subpopulation.” EUROPEAN JOURNAL OF CANCER PREVENTION, vol. 27, no. 1, 2018, pp. 46–53, doi:10.1097/CEJ.0000000000000271.
APA
Menon, S., Rossi, R., Benoy, I., Bogers, J., & Vanden Broeck, D. (2018). Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation. EUROPEAN JOURNAL OF CANCER PREVENTION, 27(1), 46–53. https://doi.org/10.1097/CEJ.0000000000000271
Chicago author-date
Menon, Sonia, Rodolfo Rossi, Ina Benoy, Johannes Bogers, and Davy Vanden Broeck. 2018. “Human Papilloma Virus Infection in HIV-Infected Women in Belgium : Implications for Prophylactic Vaccines within This Subpopulation.” EUROPEAN JOURNAL OF CANCER PREVENTION 27 (1): 46–53. https://doi.org/10.1097/CEJ.0000000000000271.
Chicago author-date (all authors)
Menon, Sonia, Rodolfo Rossi, Ina Benoy, Johannes Bogers, and Davy Vanden Broeck. 2018. “Human Papilloma Virus Infection in HIV-Infected Women in Belgium : Implications for Prophylactic Vaccines within This Subpopulation.” EUROPEAN JOURNAL OF CANCER PREVENTION 27 (1): 46–53. doi:10.1097/CEJ.0000000000000271.
Vancouver
1.
Menon S, Rossi R, Benoy I, Bogers J, Vanden Broeck D. Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation. EUROPEAN JOURNAL OF CANCER PREVENTION. 2018;27(1):46–53.
IEEE
[1]
S. Menon, R. Rossi, I. Benoy, J. Bogers, and D. Vanden Broeck, “Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation,” EUROPEAN JOURNAL OF CANCER PREVENTION, vol. 27, no. 1, pp. 46–53, 2018.
@article{8546947,
  abstract     = {{Although high-risk (HR) human papilloma virus (HPV) infection is the primary causative factor for cervical squamous intraepithelial lesions and invasive cervical cancer, the epidemiology of potentially HR (pHR) and low-risk HPV still remains to be elucidated in HIV-infected women. In addition, the synergistic potential of the multiplicity of HPV infections harboured renders it difficult to model the impact of vaccines. This cross-sectional analysis of HIV-infected women explores the epidemiology of abnormal cytology, thereby profiling and pairing pHR/HR HPV genotypes. This cross-sectional analysis reports the findings of 593 HIV-infected women, who underwent a cytological examination and HPV genotyping. A logistic regression model was fitted to adjust for age and coinfection with pHR/HR HPV genotypes. In the 143 women with abnormal cytology, a multiple pHR/HR HPV genotype prevalence of 64.1% [95% confidence interval (CI): 44.6-57.6%] was observed. A combined prevalence of HPV 16 and HPV 18 of 29.6% (95% CI: 22.2-37.8%) was found. HPV 6 and HPV 66 were found in two cases of low-grade squamous intraepithelial lesions as stand-alone genotypes and HPV 53 in a high-grade squamous intraepithelial lesion case. Pairing involving HPV 31 with HPV 16 and HPV 58 was found in high-grade squamous intraepithelial lesion cases. Significant associations were observed between abnormal cytology, multiple HPV, HPV 39 and HPV 53 [adjusted odds ratio (aOR): 2.02; P=0.01; 95% CI: 1.2-3.5; aOR: 3.8; P=0.01; 95% CI: 1.4-10.7; and aOR: 0.5; P=0.03; 95% CI: 0.2-0.9, respectively]. Coinfection with pHR/HR HPV genotypes HPV 39 and 53 was significantly associated with abnormal cytology. Research into the imputed role of HPV 31 in pairings, low-risk and pHR HPV genotypes in HIV-infected women is warranted.}},
  author       = {{Menon, Sonia and Rossi, Rodolfo and Benoy, Ina and Bogers, Johannes and Vanden Broeck, Davy}},
  issn         = {{0959-8278}},
  journal      = {{EUROPEAN JOURNAL OF CANCER PREVENTION}},
  keywords     = {{HUMAN-IMMUNODEFICIENCY-VIRUS,SQUAMOUS INTRAEPITHELIAL LESIONS,RIO-DE-JANEIRO,CERVICAL-CANCER,HIGH PREVALENCE,POSITIVE WOMEN,HPV,GENOTYPES,RISK-FACTORS,GUIDELINES,CYTOLOGY,high-risk human papilloma virus,HIV,low-risk human papilloma virus,multiple potential high-risk,high-risk coinfections,potential,high-risk human papilloma virus,vaccine efficacy}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{46--53}},
  title        = {{Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation}},
  url          = {{http://dx.doi.org/10.1097/CEJ.0000000000000271}},
  volume       = {{27}},
  year         = {{2018}},
}

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