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Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation

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Abstract
Although high-risk (HR) human papilloma virus (HPV) infection is the primary causative factor for cervical squamous intraepithelial lesions and invasive cervical cancer, the epidemiology of potentially HR (pHR) and low-risk HPV still remains to be elucidated in HIV-infected women. In addition, the synergistic potential of the multiplicity of HPV infections harboured renders it difficult to model the impact of vaccines. This cross-sectional analysis of HIV-infected women explores the epidemiology of abnormal cytology, thereby profiling and pairing pHR/HR HPV genotypes. This cross-sectional analysis reports the findings of 593 HIV-infected women, who underwent a cytological examination and HPV genotyping. A logistic regression model was fitted to adjust for age and coinfection with pHR/HR HPV genotypes. In the 143 women with abnormal cytology, a multiple pHR/HR HPV genotype prevalence of 64.1% [95% confidence interval (CI): 44.6-57.6%] was observed. A combined prevalence of HPV 16 and HPV 18 of 29.6% (95% CI: 22.2-37.8%) was found. HPV 6 and HPV 66 were found in two cases of low-grade squamous intraepithelial lesions as stand-alone genotypes and HPV 53 in a high-grade squamous intraepithelial lesion case. Pairing involving HPV 31 with HPV 16 and HPV 58 was found in high-grade squamous intraepithelial lesion cases. Significant associations were observed between abnormal cytology, multiple HPV, HPV 39 and HPV 53 [adjusted odds ratio (aOR): 2.02; P=0.01; 95% CI: 1.2-3.5; aOR: 3.8; P=0.01; 95% CI: 1.4-10.7; and aOR: 0.5; P=0.03; 95% CI: 0.2-0.9, respectively]. Coinfection with pHR/HR HPV genotypes HPV 39 and 53 was significantly associated with abnormal cytology. Research into the imputed role of HPV 31 in pairings, low-risk and pHR HPV genotypes in HIV-infected women is warranted.
Keywords
HUMAN-IMMUNODEFICIENCY-VIRUS, SQUAMOUS INTRAEPITHELIAL LESIONS, RIO-DE-JANEIRO, CERVICAL-CANCER, HIGH PREVALENCE, POSITIVE WOMEN, HPV, GENOTYPES, RISK-FACTORS, GUIDELINES, CYTOLOGY, high-risk human papilloma virus, HIV, low-risk human papilloma virus, multiple potential high-risk, high-risk coinfections, potential, high-risk human papilloma virus, vaccine efficacy

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Chicago
Menon, Sonia, Rodolfo Rossi, Ina Benoy, Johannes Bogers, and Davy Vanden Broeck. 2018. “Human Papilloma Virus Infection in HIV-infected Women in Belgium : Implications for Prophylactic Vaccines Within This Subpopulation.” European Journal of Cancer Prevention 27 (1): 46–53.
APA
Menon, S., Rossi, R., Benoy, I., Bogers, J., & Vanden Broeck, D. (2018). Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation. EUROPEAN JOURNAL OF CANCER PREVENTION, 27(1), 46–53.
Vancouver
1.
Menon S, Rossi R, Benoy I, Bogers J, Vanden Broeck D. Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation. EUROPEAN JOURNAL OF CANCER PREVENTION. 2018;27(1):46–53.
MLA
Menon, Sonia, Rodolfo Rossi, Ina Benoy, et al. “Human Papilloma Virus Infection in HIV-infected Women in Belgium : Implications for Prophylactic Vaccines Within This Subpopulation.” EUROPEAN JOURNAL OF CANCER PREVENTION 27.1 (2018): 46–53. Print.
@article{8546947,
  abstract     = {Although high-risk (HR) human papilloma virus (HPV) infection is the primary causative factor for cervical squamous intraepithelial lesions and invasive cervical cancer, the epidemiology of potentially HR (pHR) and low-risk HPV still remains to be elucidated in HIV-infected women. In addition, the synergistic potential of the multiplicity of HPV infections harboured renders it difficult to model the impact of vaccines. This cross-sectional analysis of HIV-infected women explores the epidemiology of abnormal cytology, thereby profiling and pairing pHR/HR HPV genotypes. This cross-sectional analysis reports the findings of 593 HIV-infected women, who underwent a cytological examination and HPV genotyping. A logistic regression model was fitted to adjust for age and coinfection with pHR/HR HPV genotypes. In the 143 women with abnormal cytology, a multiple pHR/HR HPV genotype prevalence of 64.1\% [95\% confidence interval (CI): 44.6-57.6\%] was observed. A combined prevalence of HPV 16 and HPV 18 of 29.6\% (95\% CI: 22.2-37.8\%) was found. HPV 6 and HPV 66 were found in two cases of low-grade squamous intraepithelial lesions as stand-alone genotypes and HPV 53 in a high-grade squamous intraepithelial lesion case. Pairing involving HPV 31 with HPV 16 and HPV 58 was found in high-grade squamous intraepithelial lesion cases. Significant associations were observed between abnormal cytology, multiple HPV, HPV 39 and HPV 53 [adjusted odds ratio (aOR): 2.02; P=0.01; 95\% CI: 1.2-3.5; aOR: 3.8; P=0.01; 95\% CI: 1.4-10.7; and aOR: 0.5; P=0.03; 95\% CI: 0.2-0.9, respectively]. Coinfection with pHR/HR HPV genotypes HPV 39 and 53 was significantly associated with abnormal cytology. Research into the imputed role of HPV 31 in pairings, low-risk and pHR HPV genotypes in HIV-infected women is warranted.},
  author       = {Menon, Sonia and Rossi, Rodolfo and Benoy, Ina and Bogers, Johannes and Vanden Broeck, Davy},
  issn         = {0959-8278},
  journal      = {EUROPEAN JOURNAL OF CANCER PREVENTION},
  language     = {eng},
  number       = {1},
  pages        = {46--53},
  title        = {Human papilloma virus infection in HIV-infected women in Belgium : implications for prophylactic vaccines within this subpopulation},
  url          = {http://dx.doi.org/10.1097/CEJ.0000000000000271},
  volume       = {27},
  year         = {2018},
}

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