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Proteogenomics in aid of host-pathogen interaction studies : a bacterial perspective

Ursula Fels (UGent) , Kris Gevaert (UGent) and Petra Van Damme (UGent)
(2017) PROTEOMES. 5(4).
Author
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Abstract
By providing useful tools to study host-pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously. However, since great discriminative power is required to study pathogen and host simultaneously throughout the infection process, the depth of quantitative gene expression profiling has proven to be unsatisfactory when focusing on bacterial pathogens, thus preferentially requiring specific strategies or the development of novel methodologies based on complementary omics approaches. In this review, we focus on the difficulties encountered when making use of proteogenomics approaches to study bacterial pathogenesis. In addition, we review different omics strategies (i.e., transcriptomics, proteomics and secretomics) and their applications for studying interactions of pathogens with their host.
Keywords
host-pathogen interaction, bacterial pathogens, infection biology, proteogenomics, DUAL RNA-SEQ, ENTERICA SEROVAR TYPHIMURIUM, LISTERIA-MONOCYTOGENES, SALMONELLA-ENTERICA, PROTEOMIC ANALYSIS, ESCHERICHIA-COLI, IN-VIVO, STAPHYLOCOCCUS-AUREUS, SHIGELLA-FLEXNERI, EPITHELIAL-CELLS

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Citation

Please use this url to cite or link to this publication:

MLA
Fels, Ursula, et al. “Proteogenomics in Aid of Host-Pathogen Interaction Studies : A Bacterial Perspective.” PROTEOMES, vol. 5, no. 4, 2017, doi:10.3390/proteomes5040026.
APA
Fels, U., Gevaert, K., & Van Damme, P. (2017). Proteogenomics in aid of host-pathogen interaction studies : a bacterial perspective. PROTEOMES, 5(4). https://doi.org/10.3390/proteomes5040026
Chicago author-date
Fels, Ursula, Kris Gevaert, and Petra Van Damme. 2017. “Proteogenomics in Aid of Host-Pathogen Interaction Studies : A Bacterial Perspective.” PROTEOMES 5 (4). https://doi.org/10.3390/proteomes5040026.
Chicago author-date (all authors)
Fels, Ursula, Kris Gevaert, and Petra Van Damme. 2017. “Proteogenomics in Aid of Host-Pathogen Interaction Studies : A Bacterial Perspective.” PROTEOMES 5 (4). doi:10.3390/proteomes5040026.
Vancouver
1.
Fels U, Gevaert K, Van Damme P. Proteogenomics in aid of host-pathogen interaction studies : a bacterial perspective. PROTEOMES. 2017;5(4).
IEEE
[1]
U. Fels, K. Gevaert, and P. Van Damme, “Proteogenomics in aid of host-pathogen interaction studies : a bacterial perspective,” PROTEOMES, vol. 5, no. 4, 2017.
@article{8546513,
  abstract     = {By providing useful tools to study host-pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously. However, since great discriminative power is required to study pathogen and host simultaneously throughout the infection process, the depth of quantitative gene expression profiling has proven to be unsatisfactory when focusing on bacterial pathogens, thus preferentially requiring specific strategies or the development of novel methodologies based on complementary omics approaches. In this review, we focus on the difficulties encountered when making use of proteogenomics approaches to study bacterial pathogenesis. In addition, we review different omics strategies (i.e., transcriptomics, proteomics and secretomics) and their applications for studying interactions of pathogens with their host.},
  articleno    = {26},
  author       = {Fels, Ursula and Gevaert, Kris and Van Damme, Petra},
  issn         = {2227-7382},
  journal      = {PROTEOMES},
  keywords     = {host-pathogen interaction,bacterial pathogens,infection biology,proteogenomics,DUAL RNA-SEQ,ENTERICA SEROVAR TYPHIMURIUM,LISTERIA-MONOCYTOGENES,SALMONELLA-ENTERICA,PROTEOMIC ANALYSIS,ESCHERICHIA-COLI,IN-VIVO,STAPHYLOCOCCUS-AUREUS,SHIGELLA-FLEXNERI,EPITHELIAL-CELLS},
  language     = {eng},
  number       = {4},
  pages        = {19},
  title        = {Proteogenomics in aid of host-pathogen interaction studies : a bacterial perspective},
  url          = {http://dx.doi.org/10.3390/proteomes5040026},
  volume       = {5},
  year         = {2017},
}

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