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Chronic dietary intake of enniatin B in broiler chickens has low impact on intestinal morphometry and hepatic histology, and shows limited transfer to liver tissue

(2018) TOXINS. 10(1).
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Abstract
The Fusarium mycotoxin enniatin B (ENN B) is a so-called emerging mycotoxin frequently contaminating poultry feed. To investigate the impact of chronic ENN B exposure on animal health, broiler chickens were fed either a diet naturally contaminated with ENN B (2352 mu g/kg) or a control diet (135 mu g/kg) for 2, 7, 14, or 21 days. ENN B concentrations were determined in plasma and liver using a validated ultra-high performance liquid chromatographytandem mass spectrometry UHPLC-MS/MS method. Liver was evaluated histologically, and the villus length and crypt depth of the duodenum, jejunum, and ileum were measured. Histopathology of the livers did not reveal major abnormalities. Feeding an ENN B-contaminated diet could possibly inhibit the proliferation of enterocytes in the duodenal crypts, but did not affect villus length, crypt depth, or villus length-crypt depth ratio of the jejunum and ileum. ENN B levels in plasma and liver were significantly higher in the ENN B-fed group and ranged between <25-264 pg/mL and <0.05-0.85 ng/g, respectively. ENN B carry-over rates from feed to liver tissue were 0.005-0.014% and 0.034-0.109% in the ENN B and control group, respectively. Carry-over rates were low and indicated a limited contribution of poultry tissue-derived products to the total dietary ENN B intake for humans. The above results support the opinion of the European Food Safety Authority stating that adverse health effects from ENN B in broiler chickens are unlikely.
Keywords
Enniatin B, broiler chicken, chronic dietary intake, carry-over, liver residue, intestinal toxicity, EMERGING FUSARIUM-MYCOTOXINS, LC-MS/MS, ORAL BIOAVAILABILITY, CACO-2 CELLS, IN-VITRO, BEAUVERICIN, TOXICOKINETICS, DEOXYNIVALENOL, MONILIFORMIN, BARRIER

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Citation

Please use this url to cite or link to this publication:

Chicago
Fraeyman, Sophie, Siska Croubels, Mathias Devreese, Richard Ducatelle, Michael Rychlik, and Gunther Antonissen. 2018. “Chronic Dietary Intake of Enniatin B in Broiler Chickens Has Low Impact on Intestinal Morphometry and Hepatic Histology, and Shows Limited Transfer to Liver Tissue.” Toxins 10 (1).
APA
Fraeyman, S., Croubels, S., Devreese, M., Ducatelle, R., Rychlik, M., & Antonissen, G. (2018). Chronic dietary intake of enniatin B in broiler chickens has low impact on intestinal morphometry and hepatic histology, and shows limited transfer to liver tissue. TOXINS, 10(1). Presented at the 1st International MYCOKEY conference: Advances on Mycotoxin Reduction in the Food and Feed Chain .
Vancouver
1.
Fraeyman S, Croubels S, Devreese M, Ducatelle R, Rychlik M, Antonissen G. Chronic dietary intake of enniatin B in broiler chickens has low impact on intestinal morphometry and hepatic histology, and shows limited transfer to liver tissue. TOXINS. 2018;10(1).
MLA
Fraeyman, Sophie, Siska Croubels, Mathias Devreese, et al. “Chronic Dietary Intake of Enniatin B in Broiler Chickens Has Low Impact on Intestinal Morphometry and Hepatic Histology, and Shows Limited Transfer to Liver Tissue.” TOXINS 10.1 (2018): n. pag. Print.
@article{8546056,
  abstract     = {The Fusarium mycotoxin enniatin B (ENN B) is a so-called emerging mycotoxin frequently contaminating poultry feed. To investigate the impact of chronic ENN B exposure on animal health, broiler chickens were fed either a diet naturally contaminated with ENN B (2352 mu g/kg) or a control diet (135 mu g/kg) for 2, 7, 14, or 21 days. ENN B concentrations were determined in plasma and liver using a validated ultra-high performance liquid chromatographytandem mass spectrometry UHPLC-MS/MS method. Liver was evaluated histologically, and the villus length and crypt depth of the duodenum, jejunum, and ileum were measured. Histopathology of the livers did not reveal major abnormalities. Feeding an ENN B-contaminated diet could possibly inhibit the proliferation of enterocytes in the duodenal crypts, but did not affect villus length, crypt depth, or villus length-crypt depth ratio of the jejunum and ileum. ENN B levels in plasma and liver were significantly higher in the ENN B-fed group and ranged between {\textlangle}25-264 pg/mL and {\textlangle}0.05-0.85 ng/g, respectively. ENN B carry-over rates from feed to liver tissue were 0.005-0.014\% and 0.034-0.109\% in the ENN B and control group, respectively. Carry-over rates were low and indicated a limited contribution of poultry tissue-derived products to the total dietary ENN B intake for humans. The above results support the opinion of the European Food Safety Authority stating that adverse health effects from ENN B in broiler chickens are unlikely.},
  articleno    = {45},
  author       = {Fraeyman, Sophie and Croubels, Siska and Devreese, Mathias and Ducatelle, Richard and Rychlik, Michael and Antonissen, Gunther},
  issn         = {2072-6651},
  journal      = {TOXINS},
  language     = {eng},
  location     = {Ghent, Belgium},
  number       = {1},
  pages        = {11},
  title        = {Chronic dietary intake of enniatin B in broiler chickens has low impact on intestinal morphometry and hepatic histology, and shows limited transfer to liver tissue},
  url          = {http://dx.doi.org/10.3390/toxins10010045},
  volume       = {10},
  year         = {2018},
}

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